DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12490 and vglu-3

DIOPT Version :9

Sequence 1:	NP_611722.2	Gene:	CG12490 / 37623	FlyBaseID:	FBgn0034782	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_499277.1	Gene:	vglu-3 / 176442	WormBaseID:	WBGene00011556	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	469	Identity:	119/469 - (25%)
Similarity:	204/469 - (43%)	Gaps:	40/469 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ALLIFLNITTVFIGRLNVGVSVVAMTNAETTNPNFP---------EYDWTEAEKSYIFSSFFWGY 73
            |:|........|..|.|.||:...|.|      ||.         |:.||.||...:.||||:||
Worm    51 AILAHFGFAISFGIRSNFGVAKNRMVN------NFTDAYGEVHEREFLWTGAEVGMMESSFFYGY 109

  Fly    74 ILTQFIGGYLCKRFGVKSVMFWGVFVSGVCSALTPLFIGFGGWQAYCGI-----RVVMGLAQGLV 133
            ..:|...|.|..:|....:...|:.|:...:.|:.:...|   ..|..|     :.|.|||.|::
Worm   110 AASQIPAGVLAAKFAPNKIFMLGILVASFMNILSAISFNF---HPYTDIFVMVVQAVQGLALGVL 171

  Fly   134 FPCIHHHLAKWSPPAERNRLGALSHTGMECGNVSAMFLSGMIAKSAIGWPGISYVSAGLAFAWCA 198
            :|.:|.....|:||.||::|...:.||...|.::.:..|..:. |...|....||...:...|..
Worm   172 YPAMHGVWKFWAPPLERSKLATTAFTGSSVGVMTGLPASAYLV-SHFSWSTPFYVFGVVGIIWSL 235

  Fly   199 IWFVFAADNAVESRYITQEELHYIESSLKHNEDYHKTVIPVPWMAIWTSAPFLALTLTRCCATWG 263
            ||...::.:.....||:.:|...:...:......:.::..:||..:.||:...|:.:...|.:||
Worm   236 IWMYVSSHSPETHGYISDDEKKQVTEKIGDVAVKNMSLTTLPWRDMMTSSAVWAIIICTFCRSWG 300

  Fly   264 LSTLQAQIPTYMNGVLDMDMKSNAFFSALPFLAMWIMSYVYLIIADVLLAGNRLSLTALRKTFNS 328
            ...|.....|||..||.:|:|::.|.|..|...|.|::.....:.|.|.:..::|..|:||:.|:
Worm   301 FFLLLGNQLTYMKDVLHIDIKNSGFISIFPQFGMCIVTLATGQLCDYLRSSGKMSTEAVRKSVNT 365

  Fly   329 LAFWIPCATLIGIGFLDQEQKNLAIALMTISVGVNSGATIGSSLNTIDLSPNHASILMGILNTAV 393
            ..|.:....|..:.|:  ....:|:..:.|:...:.....|.::|..|::|.:|.|||||.| .:
Worm   366 FGFTVEAMMLGCLAFV--RDPVIAVTCLVIACTGSGSVLSGFNVNHFDIAPRYAPILMGIAN-GL 427

  Fly   394 TVVPIVTPLIVGVIVHEDDNRAEWQIVFIIAAVLFFVGNSVYLYFGTAVSQPWDAED-------- 450
            ..|..|..::...:.::  |...|:.||::|..:...|...:|.|......||..|.
Worm   428 GAVAGVGGMVTNTVTYQ--NPDGWKWVFLLAMAIDIFGVIFFLIFAKGDVLPWAREPEKEETFNE 490

  Fly   451 ---YLTVKVPELAK 461
               .:::||..|::
Worm   491 FVRRMSIKVRSLSR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12490	NP_611722.2	2A0114euk	14..450	CDD:129972	115/445 (26%)
CG12490	NP_611722.2	MFS	54..438	CDD:119392	101/388 (26%)
vglu-3	NP_499277.1	2A0114euk	47..485	CDD:129972	116/448 (26%)
vglu-3	NP_499277.1	MFS	52..471	CDD:119392	111/433 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810