DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12490 and vglu-2

DIOPT Version :9

Sequence 1:	NP_611722.2	Gene:	CG12490 / 37623	FlyBaseID:	FBgn0034782	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_499276.1	Gene:	vglu-2 / 176441	WormBaseID:	WBGene00010755	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	487	Identity:	127/487 - (26%)
Similarity:	213/487 - (43%)	Gaps:	34/487 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ETNKGPVLGMRHVQALLIFLNITTVFIGRLNVGVSVVAMTNAETTNPNF---------PEYDWTE 59
            |.||..:..:|...|||........|..|.|.||:...|.|      ||         .|:.||.
Worm    37 EDNKFFLRKVRWQIALLAHFGFAISFGIRSNFGVAKNRMIN------NFTDAYGEVHEKEFFWTG 95

  Fly    60 AEKSYIFSSFFWGYILTQFIGGYLCKRFGVKSVMFWGVFVSGVCSALTPLFIGFGGWQ--AYCGI 122
            .|...:.||||:||..:|...|.:..:|....:...|:..:.:.:.:|.:.:.|..:.  ....|
Worm    96 TEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFTDIFVMVI 160

  Fly   123 RVVMGLAQGLVFPCIHHHLAKWSPPAERNRLGALSHTGMECGNVSAMFLSGMIAKSAIGWPGISY 187
            :|:.|||.|:.:|.:|.....|:||.||::|...:.||...|.:..:..|..:. |...|....|
Worm   161 QVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLV-SHFSWSTPFY 224

  Fly   188 VSAGLAFAWCAIWFVFAADNAVESRYITQEELHYIESSLKHNEDYHKTVIPVPWMAIWTSAPFLA 252
            |...|...|..:|...:..:.....||:.:|..||...:......:.|:..:||..:.||....|
Worm   225 VFGALGIVWSILWIYVSGTSPETHGYISADEKKYITEKVGSVAVKNMTLTTLPWRDMMTSTAVWA 289

  Fly   253 LTLTRCCATWGLSTLQAQIPTYMNGVLDMDMKSNAFFSALPFLAMWIMSYVYLIIADVLLAGNRL 317
            :.:...|.:|....|.....|||..||.:|:|::...:..|.|.|.|::.....::|.|.:..::
Worm   290 IIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSSGKM 354

  Fly   318 SLTALRKTFNSLAFWIPCATLIGIGFLDQEQKNLAIALMTISVGVNSGATI-GSSLNTIDLSPNH 381
            |..|:||:.|:..|.:....|..:.|:  ....:|:..:.|:.. .:||.: |.::|..|::|.|
Worm   355 STEAVRKSVNTFGFTVEAVMLGCLAFV--RDPVIAVTFLIIACS-GAGAVLSGFNVNHFDIAPRH 416

  Fly   382 ASILMGILNTAVTVVPIVTPLIVGVIVHEDDNRAEWQIVFIIAAVLFFVGNSVYLYFGTAVSQPW 446
            |.|||||.| .:..:..|..::...:.::  |...||.||::|..:...|...:|.|......||
Worm   417 APILMGIAN-GLGAIAGVGGIVTNSLTYQ--NPDGWQWVFLLAMSIDIFGIIFFLIFAKGDVLPW 478

  Fly   447 DAEDYLTVKVPELAKVPAIHEAGKGIDDLPRS 478
            ..|       ||  |....:|..:.:..:.||
Worm   479 ARE-------PE--KEETFNEFVRRMSTMVRS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12490	NP_611722.2	2A0114euk	14..450	CDD:129972	117/447 (26%)
CG12490	NP_611722.2	MFS	54..438	CDD:119392	101/386 (26%)
vglu-2	NP_499276.1	MFS	51..458	CDD:391944	111/419 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810