DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12490 and Slc17a7

DIOPT Version :9

Sequence 1:	NP_611722.2	Gene:	CG12490 / 37623	FlyBaseID:	FBgn0034782	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	XP_038966881.1	Gene:	Slc17a7 / 116638	RGDID:	620101	Length:	585	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	143/493 - (29%)
Similarity:	232/493 - (47%)	Gaps:	59/493 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTAETNKGPV-------LGMRHVQALLIFLNITTVFIGRLNVGVSVVAMTNAETTN--------- 49
            :|..|...||       |..|::.|::..|.....|..|.|:||::|:|.|..||:
  Rat    42 VTTHTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQT 106

  Fly    50 ------------PNF----------PEYDWTEAEKSYIFSSFFWGYILTQFIGGYLCKRFGVKSV 92
                        |..          .:::|.......|..|||||||:||..||::|::|....|
  Rat   107 PYRSVHKQEAVTPTVGDIQGGDTEKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRV 171

  Fly    93 MFWGVFVSGVCSALTPLFIGFGGWQAYCG----IRVVMGLAQGLVFPCIHHHLAKWSPPAERNRL 153
            ..:.:..:...:.|.|     ...:.:.|    :|::.||.:|:.:|..|...:||:||.||:||
  Rat   172 FGFAIVATSTLNMLIP-----SAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRL 231

  Fly   154 GALSHTGMECGNVSAMFLSGMIAKSAIGWPGISYVSAGLAFAWCAIWFVFAADNAVESRYITQEE 218
            ...:..|...|.|.||.|:|::.:.: ||..:.||.......|...|.:.:.::......|::||
  Rat   232 ATTAFCGSYAGAVVAMPLAGVLVQYS-GWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEE 295

  Fly   219 LHYIESSLKHNEDYHKTVIPV-----PWMAIWTSAPFLALTLTRCCATWGLSTLQAQIPTYMNGV 278
            ..|||.::..:.   |.:.||     ||...:||.|..|:.:...|.:|....|....|.|...|
  Rat   296 RKYIEDAIGESA---KLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEV 357

  Fly   279 LDMDMKSNAFFSALPFLAMWIMSYVYLIIADVLLAGNRLSLTALRKTFNSLAFWIPCATLIGIGF 343
            ...::......||||.|.|.|:..:...|||.|.:.:.:|.|.:||..|...|.:....|:.:|:
  Rat   358 FGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGY 422

  Fly   344 LDQEQKNLAIALMTISVGVNSGATIGSSLNTIDLSPNHASILMGILNTAVTVVPIVTPLIVGVIV 408
              ...|.:||:.:.::||.:..|..|.::|.:|::|.:|||||||.|...|:..:|.|:|||.:.
  Rat   423 --SHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMT 485

  Fly   409 HEDDNRAEWQIVFIIAAVLFFVGNSVYLYFGTAVSQPW 446
             :...|.|||.||:||:::.:.|...|..|.:...|||
  Rat   486 -KHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPW 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12490	NP_611722.2	2A0114euk	14..450	CDD:129972	138/473 (29%)
CG12490	NP_611722.2	MFS	54..438	CDD:119392	120/392 (31%)
Slc17a7	XP_038966881.1	MFS_SLC17A6_7_8_VGluT	66..515	CDD:340940	133/460 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342474
Domainoid	1	1.000	47	1.000	Domainoid score	I11657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840