DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30265 and SLC17A6

DIOPT Version :9

Sequence 1:	NP_001286747.1	Gene:	CG30265 / 37622	FlyBaseID:	FBgn0050265	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_065079.1	Gene:	SLC17A6 / 57084	HGNCID:	16703	Length:	582	Species:	Homo sapiens

Alignment Length:	488	Identity:	155/488 - (31%)
Similarity:	236/488 - (48%)	Gaps:	49/488 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KGPL-------LGMRHVQTLL--LFFNITCLYIG-RLNVGVAVVAMTNAESTN------PDFPEY 55
            |.||       |..|::..::  |.|   |:..| |.|:|||:|.|.|..:.:      .:..::
Human    56 KAPLCDCTCFGLPRRYIIAIMSGLGF---CISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKF 117

  Fly    56 DWTLTQKSYILSSFFWGYIITQFLGGYLCKRYGVKSVMLWGSFASGIF--SALTPLFIGFGEWQA 118
            :|.......|..||||||||||..|||:..|.....|     |.:.|.  |.|..|.........
Human   118 NWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRV-----FGAAILLTSTLNMLIPSAARVHY 177

  Fly   119 YCGI--RVLMGFAQGLIFPCIHQHLARWSPPAERNRLGALSHTGIECGNVCAMFFSGMIAKSAIG 181
            .|.|  |:|.|..:|:.:|..|...::|:||.||:||...|..|...|.|.||..:|::.:.. |
Human   178 GCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYT-G 241

  Fly   182 WPGISYVSAGLALAWCAFWFVFAADNAEESRYITQEELHYIESSLKHNE------DYHKTVIPVP 240
            |..:.||.....:.|..||.:.:.::..:...||.||..|||.|:..:.      :..||    |
Human   242 WSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKT----P 302

  Fly   241 WMAIWTSAPFFALMVARCCETWGLSTLQAQIPTYMNGVLDMDMKSNAFFSALPFLAMWIMSYVYL 305
            |...:||.|.:|::||..|.:|....|....|.|...|...::......||:|.|.|.|:..:..
Human   303 WRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGG 367

  Fly   306 IIADVLLAGNRLSLTALRKIFNSLAFWIPCATLIGIGFLDQEQKNLAIALMTISVGVNSGATIGS 370
            .|||.|.:...||.|.:|||.|...|.:....|:.:|:  ...:.:||:.:.::||.:..|..|.
Human   368 QIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGY--SHTRGVAISFLVLAVGFSGFAISGF 430

  Fly   371 SLNTIDLSPNHASILMGIVNTAANVVPIVTPLAVGLIVHEDKNREEWQIVFIIAAVIFFIGNCVF 435
            ::|.:|::|.:|||||||.|....:..:|.|:.||.:. ::|:|||||.||:|||::.:.|...:
Human   431 NVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMT-KNKSREEWQYVFLIAALVHYGGVIFY 494

  Fly   436 LYYGTAVSQPW-DAEDYLTEKVPDLAIAPAIHE 467
            ..:.:...||| |.|:...||      ...|||
Human   495 AIFASGEKQPWADPEETSEEK------CGFIHE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30265	NP_001286747.1	2A0114euk	14..450	CDD:129972	145/455 (32%)
CG30265	NP_001286747.1	MFS	18..438	CDD:119392	140/438 (32%)
SLC17A6	NP_065079.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	140/439 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11776
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820