DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30265 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_001286747.1	Gene:	CG30265 / 37622	FlyBaseID:	FBgn0050265	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	147/446 - (32%)
Similarity:	223/446 - (50%)	Gaps:	30/446 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CLYIG-RLNVGVAVVAMTNAESTNPD-FPE-----YDWTLTQKSYILSSFFWGYIITQFLGGYLC 84
            |:..| |.|:|||:|.|.|..:...| .||     ::|.......|..|||||||:||..||::.
  Rat    87 CISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFIS 151

  Fly    85 KRYGVKSVMLWGSFASGIFSALT-PLFIGFGEWQAY----CGIRVLMGFAQGLIFPCIHQHLARW 144
            .::....|     |.:.||...| .:||.......|    | :|:|.|..:|:.:|..|...::|
  Rat   152 NKFAANRV-----FGAAIFLTSTLNMFIPSAARVHYGCVMC-VRILQGLVEGVTYPACHGMWSKW 210

  Fly   145 SPPAERNRLGALSHTGIECGNVCAMFFSGMIAKSAIGWPGISYVSAGLALAWCAFWFVFAADNAE 209
            :||.||:||...|..|...|.|.||..:|::.: .|||..:.|:.....:.|..||.:.|.:...
  Rat   211 APPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ-YIGWASVFYIYGMFGIIWYMFWLLQAYECPA 274

  Fly   210 ESRYITQEELHYIESSLKHNEDYHK-TVIPVPWMAIWTSAPFFALMVARCCETWGLSTLQAQIPT 273
            ....|:.||..|||:|:....:... :....||...:||.|.:|::||..|.:|....|....|.
  Rat   275 VHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPA 339

  Fly   274 YMNGVLDMDMKSNAFFSALPFLAMWIMSYVYLIIADVLLAGNRLSLTALRKIFNSLAFWIPCATL 338
            |...|....:......||:|.:.|.|:..:...:||.|.:...|:.||:|||.|...|.:....|
  Rat   340 YFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLL 404

  Fly   339 IGIGFLDQEQKNLAIALMTISVGVNSGATIGSSLNTIDLSPNHASILMGIVNTAANVVPIVTPLA 403
            :.:||  ...|.:||:.:.::||.:..|..|.::|.:|::|.:|||||||.|....:..:|.||.
  Rat   405 LVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLI 467

  Fly   404 VGLIVHEDKNREEWQIVFIIAAVIFFIGNCVFLYYGTAVS---QPW-DAEDYLTEK 455
            ||.:. :.|.|||||.||:|||::.:.|   .::||...|   |.| |.|:...||
  Rat   468 VGAMT-KHKTREEWQNVFLIAALVHYSG---VIFYGVFASGEKQDWADPENLSEEK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30265	NP_001286747.1	2A0114euk	14..450	CDD:129972	144/439 (33%)
CG30265	NP_001286747.1	MFS	18..438	CDD:119392	138/423 (33%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	140/427 (33%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342506
Domainoid	1	1.000	47	1.000	Domainoid score	I11657
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750