DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30265 and slc-17.5

DIOPT Version :9

Sequence 1:	NP_001286747.1	Gene:	CG30265 / 37622	FlyBaseID:	FBgn0050265	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_505139.1	Gene:	slc-17.5 / 184790	WormBaseID:	WBGene00017681	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	124/530 - (23%)
Similarity:	221/530 - (41%)	Gaps:	99/530 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PLLGMR----HVQTLLLFFNITCLYIGRLNVGVAVVAMTNA-----------------EST---- 48
            |.|.:|    || .|:|.:...|:.....::|:::..|.|:                 |||
Worm    16 PFLHIRSRRLHV-VLMLMYAFFCMCQMTAHIGLSLSCMCNSTAVALMNTNNATLVEGTESTILMS 79

  Fly    49 -------------NPDFPE----------------YDWTLTQKSYILSSFFWGYIITQFLGGYLC 84
                         ..|..|                :.|:::.:.||:|:.|.|..|..:..|.|.
Worm    80 ILENKTSESQELGGGDDGESCTKLEGKVIKDYGGTFIWSVSWQGYIVSAAFLGGFIFSYPAGVLV 144

  Fly    85 KRYGVKSVMLWGSFASGIFSALTP-LFIGFGEWQAYCGIRVLMGFAQGLIFPCIHQHLARWSPPA 148
            .|:..:.::........|.|.|.| |.|..||..|:.| |.:||.::.::.|.|:..:.:|.|..
Worm   145 DRFSARHILSVAILMLTIASLLMPVLSIYIGEKGAFAG-RFVMGISETMLIPSINSMVTKWIPIN 208

  Fly   149 ERNRLGALSHTGIECGN-VCAMFFSGMIAK---SAIGWPGISYVSAGLALAWCAFWFVFAADNAE 209
            |:    :|:.:....|| :..||.:.::|:   |:.||..|.|.::...::|...|.:...::..
Worm   209 EK----SLAASVFTAGNQLSGMFGNILVAELCASSFGWSSIFYSASLFGISWLVLWHLTVRNSPH 269

  Fly   210 ESRYITQEELHYIESSL--KHNEDYHKTVIPVPWMAIWTSAPFFALMVARCCETWGLSTLQAQIP 272
            .:|:|.:.||.|:.:::  ||..   ..|...||..:.||..|::||.........::.:...||
Worm   270 NTRWIHKRELDYLANNIPPKHPS---SVVKKTPWRDMLTSKVFWSLMFNSVMGNMMIALIFVYIP 331

  Fly   273 TYMNGVLDMDMKSNAFFSALPFLAMWIMSYVYLIIADVLLAGNRLSLTALRKIFNSLAFWIPCAT 337
            .|...||.:|::||.|:||:|.::..|...::..:.|.:.....||.:|..|:..       .|:
Worm   332 VYFKDVLMLDVQSNGFYSAIPHISNLIAKLIWGYLMDKMRHKKILSPSATVKLSQ-------FAS 389

  Fly   338 LIGIG-------FLDQEQKNLAIALMTISVGVNSGATI-GSSLNTIDLSPNHASILMGIVNTAAN 394
            ::||.       :::......|:.|:: ||....|.:| |...:.:.::|:|...|..:......
Worm   390 MMGISVSCFFLRYMNCATPFYALVLLS-SVSAFFGLSISGFYTSLLSIAPSHIGTLTSLATVIGF 453

  Fly   395 VVPIVTPL------AVGLIVHEDKNREEWQIVFIIAAVIFFIGNCVFLYYGTAVSQPWDAEDYLT 453
            |..:.|||      .||       ..|||..|.:|.......|..:||.:|:...|.||......
Worm   454 VGRMFTPLMISYYKTVG-------TAEEWGHVLLIYVFASATGGIIFLLFGSGDVQNWDYSKRHN 511

  Fly   454 EKVPDLAIAP 463
            ...|:..:||
Worm   512 TARPNALVAP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30265	NP_001286747.1	2A0114euk	14..450	CDD:129972	119/510 (23%)
CG30265	NP_001286747.1	MFS	18..438	CDD:119392	112/490 (23%)
slc-17.5	NP_505139.1	MFS	108..497	CDD:391944	101/411 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28615
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930