DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42284 and Potegl

DIOPT Version :9

Sequence 1:	NP_611720.3	Gene:	CG42284 / 37621	FlyBaseID:	FBgn0259179	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_081911.1	Gene:	Potegl / 70981	MGIID:	1918231	Length:	382	Species:	Mus musculus

Alignment Length:	411	Identity:	83/411 - (20%)
Similarity:	153/411 - (37%)	Gaps:	105/411 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 EIQAFLNNV------PSYMEKIH----RVHDAARDGGLLALQQALDRRKFAIAKNDIS---PNGS 167
            :|:|..:|:      |:|::..:    .:|.||..|.|     ...|..|.:.|.:::   ....
Mouse    39 DIKARRSNLSFGREDPAYLDMAYFPDNDLHMAACAGDL-----PFVRLYFTLGKYEVNHRDRENR 98

  Fly   168 TPLHVAVLFGHTDIVRYLASRFPETMTITDNDGRTPLHYAATIKDNGHFYNMLLQLGANPKSLDK 232
            ..:|.|..:||.::|.||..|..| :.:.||...|||..|....:: .....||:..||....|.
Mouse    99 NAMHFACFYGHLELVIYLWRRGCE-INVCDNHNITPLMKAVQSWED-KIVCFLLEHHANLHIKDS 161

  Fly   233 LGHSAEFYLDKEKAKNILNYTELLNIFGAEELENQLLNDQGQAQPVSFQANPIFKTEQGKYLADS 297
            :|::|..|  ...:.|:.....||. :||:..|                     :|:      |:
Mouse   162 MGNTALHY--AVYSGNLATAARLLQ-YGADIEE---------------------RTK------DN 196

  Fly   298 LADPLIKALTEIANKRPRDPVAYLTNYLQHFMGDRKPMTEVQVHSGSSKASTSSTSTLALPKSNA 362
            |. ||:.||.|              |.|:  |.......|..||:..|:...|....:..
Mouse   197 LT-PLLLALRE--------------NRLK--MAQFLVRMEASVHAVDSQRRNSLMYAVRC----- 239

  Fly   363 SSNQRLGNTRNGPGPTNADL---IELDARSVAEDEDAEGALAVQHMEERDEHGQSMLHFACARSH 424
                      :.|...|..|   ::::.:      |..|..|:::..|.|...::||    ....
Mouse   240 ----------DSPVMVNLILQQGVDINLK------DLFGWTALRYAIEGDRDVRTML----LELR 284

  Fly   425 RRGALYTLIEESGIDITYR---DELYRTARDVSLQANQP--NNAAEIDRYVMAQAVIGDVEPF-- 482
            :|...:...|.|.|.:..:   :....||.:..::...|  .|.|.:::....:....::|.|
Mouse   285 KRNRAFQSSENSSIRLINKADAEVTSPTANEKVIEMQDPFTTNEASVEKTQTRRPAESELEVFSL 349

  Fly   483 -EQLALQGYDHILDIEDENGQ 502
             |:::.:  :.|.:::...||
Mouse   350 EEEISYK--ETINNLQQNPGQ 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42284	NP_611720.3	ANK	135..250	CDD:238125	32/117 (27%)
		Ank_2	135..231	CDD:289560	27/98 (28%)
		ANK repeat	165..197	CDD:293786	9/31 (29%)
		Dpy-30	289..330	CDD:253069	9/40 (23%)
		ANK	407..585	CDD:238125	19/104 (18%)
		ANK	533..649	CDD:238125
		Ank_2	533..630	CDD:289560
		ANK repeat	564..596	CDD:293786
		ANK repeat	598..630	CDD:293786
Potegl	NP_081911.1	Ank_4	67..116	CDD:290365	13/53 (25%)
		ANK	91..216	CDD:238125	40/173 (23%)
		ANK repeat	96..127	CDD:293786	9/31 (29%)
		Ank_2	102..192	CDD:289560	29/115 (25%)
		ANK repeat	132..160	CDD:293786	8/28 (29%)
		ANK	158..281	CDD:238125	36/194 (19%)
		ANK repeat	162..193	CDD:293786	9/54 (17%)
		Ank_2	167..259	CDD:289560	26/159 (16%)
		ANK repeat	195..226	CDD:293786	13/47 (28%)
		ANK repeat	228..259	CDD:293786	4/51 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5235
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050