Protein Alignment CG42284 and Nfkb1

DIOPT Version :10

• Sequence 1: NP_611720.3
• Gene: CG42284 / 37621
• FlyBaseID: FBgn0259179
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_032715.2
• Gene: Nfkb1 / 18033
• MGIID: 97312
• Length: 971
• Species: Mus musculus
• Alignment Length: 694
• Identity: 145/694 - (20%)
• Similarity: 243/694 - (35%)
• Gaps: 233/694 - (33%)

  Fly    31 PQEGQQPGAGAQPPEDDGNESLTSAMAIEGFVHGAPEDYTVQSQTAVDENERIKRIVESGDLEQL 95
            |..|..|||.::.     |:.....:.|..:|                           |..:.:
Mouse    62 PSHGGLPGASSEK-----NKKSYPQVKICNYV---------------------------GPAKVI 94

  Fly    96 AEIVLNGE-----GGSLVG----------LKSPEPEIQAFLN---------NVPSYMEKIHRVHD 136
            .::|.||:     ..||||          ...|:..:..|.|         .|...:|.  |:.:
Mouse    95 VQLVTNGKNIHLHAHSLVGKHCEDGVCTVTAGPKDMVVGFANLGILHVTKKKVFETLEA--RMTE 157

  Fly   137 AARDG---GLLA------LQ-------QALDRRKFAIAKNDISPNGSTPLHVAVLFGHTDIVRYL 185
            |...|   |||.      ||       |..||.|..|.:..:.......|         .:||.:
Mouse   158 ACIRGYNPGLLVHSDLAYLQAEGGGDRQLTDREKEIIRQAAVQQTKEMDL---------SVVRLM 213

  Fly   186 ASRFPETMTITDNDGRTPLHYAATIKDNGHFYNMLLQLGANPKSLDKLGHSA-------EFYL-- 241
            .:.|     :.|:.|.........:.|  ..|:......:|.| :.::..:|       |.||
Mouse   214 FTAF-----LPDSTGSFTRRLEPVVSD--AIYDSKAPNASNLK-IVRMDRTAGCVTGGEEIYLLC 270

  Fly   242 DKEKAKNI-LNYTELLNIFGAEELENQLLNDQGQAQP--VSFQANPIFKTEQGKYLADSLADPL- 302
            ||.:..:| :.:.|       ||....:....|...|  |..|...:|||.  ||...::..|.
Mouse   271 DKVQKDDIQIRFYE-------EEENGGVWEGFGDFSPTDVHRQFAIVFKTP--KYKDVNITKPAS 326

  Fly   303 ----IKALTEIANKRPRDPVAYLTNYLQHFMGDRKPMTEVQ------------------------ 339
                ::..:::....|: |..|..        :.|...|||
Mouse   327 VFVQLRRKSDLETSEPK-PFLYYP--------EIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGG 382

  Fly   340 ---VHSGSSKASTSST------STLALP------------KSNASSNQRLGNT--RNGPGPTNAD 381
               ..||....||.|.      |....|            ||||.......||  :|||
Mouse   383 GGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGP------ 441

  Fly   382 LIELDARSVAEDEDAEGALAVQHMEERDEHGQS-MLHFACARSHRRGALYTLIEESGIDITYRDE 445
                  :..|:.:|.|...    :.|::..|:. .|..||.::... ||.:.:|:...|:.::|.
Mouse   442 ------KDCAKSDDEESLT----LPEKETEGEGPSLPMACTKTEPI-ALASTMEDKEQDMGFQDN 495

  Fly   446 LYRTARDVSLQANQPNNAAEIDRYVMAQAVIGDVEPFEQLALQGYDHILDIEDENGQSITDVVQS 510
            |:   .:.:||..:.:..|..|     .||.|||:..  ||:|  .|:..::||||.|:..:.
Mouse   496 LF---LEKALQLARRHANALFD-----YAVTGDVKML--LAVQ--RHLTAVQDENGDSVLHLA-- 546

  Fly   511 RQNAALGEFLANLKALEESREELHQMIRENNMERVVELTNVANAKWLIRTKNYYGRTALHIAVLK 575
                     :.:|.|         |::|:     ::|:|:...:..:|..:|...:|.||:||:.
Mouse   547 ---------IIHLHA---------QLVRD-----LLEVTSGLISDDIINMRNDLYQTPLHLAVIT 588

  Fly   576 ESEEMVQHMVKICPEGLKITDNLERTVLHYAMGTNALESVSRIL 619
            :.|::|:.::::..: |.:.|....:|||.|    |.|...|||
Mouse   589 KQEDVVEDLLRVGAD-LSLLDRWGNSVLHLA----AKEGHDRIL 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42284	NP_611720.3	Ank_2	135..231	CDD:463710	22/111 (20%)
		ANK repeat	165..197	CDD:293786	4/31 (13%)
		Dpy-30	289..330	CDD:428357	6/45 (13%)
		Ank_2	533..630	CDD:463710	24/87 (28%)
		ANK repeat	564..596	CDD:293786	8/31 (26%)
		ANK repeat	598..630	CDD:293786	9/22 (41%)
Nfkb1	NP_032715.2	RHD-n_NFkB1	40..241	CDD:143651	42/228 (18%)
		IPT_NFkappaB	248..349	CDD:238582	24/111 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	358..363		1/4 (25%)
		GRR. /evidence=ECO:0000250|UniProtKB:P19838	370..392		2/21 (10%)
		Interaction with CFLAR. /evidence=ECO:0000250|UniProtKB:P19838	433..971		63/254 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..470		9/46 (20%)
		ANKYR	492..765	CDD:440430	46/178 (26%)
		ANK repeat	538..575	CDD:293786	10/61 (16%)
		ANK repeat	577..608	CDD:293786	8/31 (26%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000250|UniProtKB:P19838	646..680
		ANK repeat	646..677	CDD:293786
		ANK repeat	680..712	CDD:293786
		Death_NFkB1_p105	812..886	CDD:260063