DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment stl and ADAMTS1

DIOPT Version :9

Sequence 1:NP_001097423.1 Gene:stl / 37619 FlyBaseID:FBgn0086408 Length:1136 Species:Drosophila melanogaster
Sequence 2:NP_008919.3 Gene:ADAMTS1 / 9510 HGNCID:217 Length:967 Species:Homo sapiens


Alignment Length:1080 Identity:240/1080 - (22%)
Similarity:368/1080 - (34%) Gaps:322/1080 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 RRSLPSEDGN----------GPLP------------------PEEEEQE--------AGEDVEAR 155
            ||.|.|:.||          ||:|                  |.||::|        |......|
Human    11 RRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGHGTTR 75

  Fly   156 LQLQQSPQLI------DDAFIFIRRT-EN-GTQFVEHSPQLLKRLERCFYR-------SPAAALD 205
            |:|....|.:      |.:|:....| :| |.:....:|.....|..|||.       |.||||.
Human    76 LRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALS 140

  Fly   206 LCEPGNVRGVFQQNGSDLVIHPLPA---RFGTGT-----------HVLYQARVDKSGG--GYSEA 254
            |||  .|||.|...|....|.||||   |..|..           |:|.:.|....||  |..:.
Human   141 LCE--GVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDD 203

  Fly   255 SSRRT----ASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRY 315
            ..|.|    ....|...:.|.:..:::.....|:...|               |......|::|:
Human   204 EPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQ---------------PTGTGSIRKKRF 253

  Fly   316 IGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLG 380
            :.           ...::||.:..|..: |...       .|.:..:||.:.:....||.||::.
Human   254 VS-----------SHRYVETMLVADQSM-AEFH-------GSGLKHYLLTLFSVAARLYKHPSIR 299

  Fly   381 RRINF-VLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLV 444
            ..::. |:|.|.|......|.:..:..:.  |.:||.||::.||.||.|..|||.|::.|..||.
Human   300 NSVSLVVVKILVIHDEQKGPEVTSNAALT--LRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLC 362

  Fly   445 TYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRH-DAKEIS----C 504
                |......:|||.|..:|....||::.|....::.|..|||:||...|.| |||:.:    .
Human   363 ----GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGV 423

  Fly   505 DPTMHIMSPKLGS--GKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNA 567
            :...|:|:..|.:  ....||.||...:..||.:...|||.|:..  .|..  ..|.|||..::|
Human   424 NQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ--NPIQ--LPGDLPGTSYDA 484

  Fly   568 NQQCMLRFGKNFMQ----ASTQSKMEICRD-----LHCRQDGLPWTSHPALEGTECGPNMWCRGG 623
            |:||...||::...    |||.|.: .|..     |.|:....||.     :||.||...||..|
Human   485 NRQCQFTFGEDSKHCPDAASTCSTL-WCTGTSGGVLVCQTKHFPWA-----DGTSCGEGKWCING 543

  Fly   624 TCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSE 688
            .|..::.:                        :|              .|....||...||.|.:
Human   544 KCVNKTDR------------------------KH--------------FDTPFHGSWGMWGPWGD 570

  Fly   689 PSACESGCLYGQSRRLLEGSTGLRTLNRSCLN-FPSR----CIGRDRRFVTCNTPQCHKVPVQTI 748
               |...|           ..|::...|.|.| .|..    |.|:..|:.:||...|   |....
Human   571 ---CSRTC-----------GGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDC---PDNNG 618

  Fly   749 NDFATQVCMQARKSDPELTGEG---QQLPSTLDAS----CKIFCRTRTNGTKSRRWTF------P 800
            ..|..:.|....:......|.|   :.:|.....|    ||:.|:.:..|     :.|      .
Human   619 KTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIG-----YFFVLQPKVV 678

  Fly   801 DGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNFFKMD--------SSFCEARSVRPTRDSSDQ 857
            |||.|     :|:..:.|:.|:|.:..||....:..|.|        .|.|:..|...|      
Human   679 DGTPC-----SPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVT------ 732

  Fly   858 ESRQQTNRQRYAERQEGKPQKNHYEN-----------EVAKRPSYGQGNHINAPASPYKRRNYHK 911
                           ..||   .|.:           ||.:|...|..|                
Human   733 ---------------SAKP---GYHDIITIPTGATNIEVKQRNQRGSRN---------------- 763

  Fly   912 PYPPEIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTG----VESIQ 972
                         :.|.:|:   .:::..::.:.....:.:......:||..|.:|    :|.|:
Human   764 -------------NGSFLAI---KAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIR 812

  Fly   973 LCSYRIQPC--------ERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQD 1029
            ..|...:|.        ..|:...:|. ....:.::....:....|.:.....|..:||.:|.|.
Human   813 SFSPLKEPLTIQVLTVGNALRPKIKYT-YFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQR 876

  Fly  1030 EFIKYRYYLVNGRNGHFPPGTRCS----PVGKRYCVYGRC 1065
            ..::.|.  :||:     |.:.|:    |...|.|....|
Human   877 RLVECRD--INGQ-----PASECAKEVKPASTRPCADHPC 909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stlNP_001097423.1 Pep_M12B_propep <155..239 CDD:279848 35/112 (31%)
ZnMc_ADAMTS_like 331..543 CDD:239801 64/219 (29%)
Reprolysin 332..545 CDD:279729 65/220 (30%)
TSP1 683..741 CDD:214559 15/62 (24%)
ADAMTS1NP_008919.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 6/15 (40%)
Pep_M12B_propep 66..166 CDD:279848 33/101 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..250 10/72 (14%)
Cysteine switch. /evidence=ECO:0000250 196..203 2/6 (33%)
Reprolysin 258..467 CDD:279729 66/222 (30%)
ZnMc_ADAMTS_like 258..463 CDD:239801 63/218 (29%)
ADAM_CR 468..548 CDD:301627 28/89 (31%)
TSP1 562..614 CDD:214559 16/68 (24%)
Spacer 725..849 22/180 (12%)
ADAM_spacer1 725..842 CDD:283607 22/173 (13%)
TSP1 858..910 CDD:214559 14/59 (24%)
TSP1 912..967 CDD:214559
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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