DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and ADAMTS2

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_055059.2	Gene:	ADAMTS2 / 9509	HGNCID:	218	Length:	1211	Species:	Homo sapiens

Alignment Length:	1206	Identity:	273/1206 - (22%)
Similarity:	411/1206 - (34%)	Gaps:	391/1206 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 RQRRSLPSEDGNGPLPPEEEEQEAGEDV---------EARLQLQQSPQLIDDAFIFIRRTENGTQ 180
            |.||:.|...   |..|...|:|.|..:         :..|:|:.:.:|:........:.|.||.
Human    85 RARRAAPVRT---PSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTT 146

  Fly   181 FVEHSPQLLKRLERCFY--------RSPAAALDLCEPGNVRGVFQQNGSDLVIHPL-------PA 230
            .||      ..|..|.|        .:.:.||..|:  .:.|:.:....:..|.||       .|
Human   147 RVE------PLLGSCLYVGDVAGLAEASSVALSNCD--GLAGLIRMEEEEFFIEPLEKGLAAQEA 203

  Fly   231 RFGTGTHVLYQARVDKSGGGYSEASSRR--TASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPL 293
            ..|. .||:|                ||  |:.||..     |.|.:.......|.:.|:....|
Human   204 EQGR-VHVVY----------------RRPPTSPPLGG-----PQALDTGASLDSLDSLSRALGVL 246

  Fly   294 RLRFQPRHHHPHQHHQQRR-RRYIGDAPRSRWSDIPEELFIETAIFVDSDLY-----AHMQKNFP 352
                     ..|.:..:|| ||:..|          ::..||..:.||..:.     .|:||
Human   247 ---------EEHANSSRRRARRHAAD----------DDYNIEVLLGVDDSVVQFHGKEHVQK--- 289

  Fly   353 TNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKW 417
                     :||.::|.|..:||..:||..||.||.|:.:........|:...:....|.:.|:|
Human   290 ---------YLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRW 345

  Fly   418 ---QEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHF 479
               |:|  |.:..|..| |||:.||..|.     |.:..|  |.|.|.|||..:.|||:|....|
Human   346 AYLQQK--PDTGHDEYH-DHAIFLTRQDF-----GPSGMQ--GYAPVTGMCHPVRSCTLNHEDGF 400

  Fly   480 ESVFVVAHEIGHNLGMRHDAKEISCDPTMH---IMSPKLGSG--KVTWSKCSRTYLEDFLMDPQA 539
            .|.||||||.||.|||.||.:...|...:.   ||:|.:.:.  :..||:||:..|..:|  ...
Human   401 SSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYL--HSY 463

  Fly   540 ECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPW- 603
            :||.| |.||..|  .|..:|||..::.|:||...||..:|..:.....:.|:.|.|.....|:
Human   464 DCLLD-DPFAHDW--PALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF 525

  Fly   604 ---TSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSW-PPEHIPEATHEKIIRHEPNRIPP 664
               ...|.|:||.|.|...|..|.|              .| .|:         |::.:
Human   526 CKTKKGPPLDGTMCAPGKHCFKGHC--------------IWLTPD---------ILKRD------ 561

  Fly   665 LLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN-FPSR---- 724
                            .:||.||...:|...|           .||::...|.|.| .|:.
Human   562 ----------------GSWGAWSPFGSCSRTC-----------GTGVKFRTRQCDNPHPANGGRT 599

  Fly   725 CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPEL---TGEGQQ--LP-STLDAS--C 781
            |.|....|..|:...|    ..::.||..:.|.|.     :|   .|:.|.  || ...||.  |
Human   600 CSGLAYDFQLCSRQDC----PDSLADFREEQCRQW-----DLYFEHGDAQHHWLPHEHRDAKERC 655

  Fly   782 KIFCRTRTNG-TKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCD---NSTSNFFKM---- 838
            .::|.:|..| ..|.:....|||.|..|    :..:.|:.|.|.:..||   .|:....|.
Human   656 HLYCESRETGEVVSMKRMVHDGTRCSYK----DAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCG 716

  Fly   839 -DSSFCEARSVRPTRDSSDQESR-----QQTNRQRYAERQEGKPQKNH--YENEVAKRPSYGQGN 895
             |:|.|:.  |:.|...|.::..     :.....|:...||.....:|  .:|....:....:.|
Human   717 GDNSHCKV--VKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEEN 779

  Fly   896 HINAPASPYKRRNYHKPYPPEIPR------------------PPPPASASL----------IALD 932
            .::|.:..:........|..|..|                  |......||          :.:|
Human   780 DVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVD 844

  Fly   933 RSSSSESEWVAH-------PGCHSNC-------------MTDSKGV-QGVTSRLTGVESI----- 971
            .::..|.:.|.:       ..|...|             ..|.|.| :|..:.|:..::|
Human   845 DNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACN 909

  Fly   972 -QLCSYRI------QPCERLQTAAEYAEQTCARYRQKVRGL------------SGHGAQISASID 1017
             |.||..:      :||          .|||.|...:||.:            |.|....:.:..
Human   910 PQECSQPVWVTGEWEPC----------SQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARP 964

  Fly  1018 EPDRSC-RVGCQDEFIKYRYYLVNGRNGHFPPGTRCS---------------------------- 1053
            |..|:| |..|...:          |.|   |.::||
Human   965 ESRRACSRELCPGRW----------RAG---PWSQCSVTCGNGTQERPVLCRTADDSFGICQEER 1016

  Fly  1054 PVGKRYCVYGRC----------------LEFGDDDLPL-----------DKTHISLGQLRTRR-- 1089
            |...|.|..|.|                |...|.|.|:           ||:.....::.:|.
Human  1017 PETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCS 1081

  Fly  1090 ---------KRSSISNDLFNITEIFIKP---SHSDI 1113
                     |..::.|:|.|: |..|:|   .|:||
Human  1082 IPGYNKLCCKSCNLYNNLTNV-EGRIEPPPGKHNDI 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	21/98 (21%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	73/224 (33%)
		Reprolysin	332..545	CDD:279729	74/225 (33%)
		TSP1	683..741	CDD:214559	16/62 (26%)
ADAMTS2	NP_055059.2	Pep_M12B_propep	100..211	CDD:279848	24/119 (20%)
		ZnMc_ADAMTS_like	266..467	CDD:239801	73/224 (33%)
		Reprolysin	268..470	CDD:279729	75/226 (33%)
		TSP1	564..616	CDD:214559	17/66 (26%)
		Cell attachment site. /evidence=ECO:0000255	691..693		0/1 (0%)
		Spacer	723..851		17/129 (13%)
		ADAM_spacer1	723..837	CDD:283607	16/115 (14%)
		TSP1	863..914	CDD:214559	9/50 (18%)
		TSP1	917..976	CDD:214559	14/68 (21%)
		TSP1	982..1029	CDD:214559	8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810