Protein Alignment stl and ADAMTS4

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_001307265.1
• Gene: ADAMTS4 / 9507
• HGNCID: 220
• Length: 846
• Species: Homo sapiens
• Alignment Length: 917
• Identity: 219/917 - (23%)
• Similarity: 317/917 - (34%)
• Gaps: 301/917 - (32%)

  Fly   130 LPSEDGNGPLPPEEE------------------------------------EQEAGEDVEARLQL 158
            |||.....|||.|||                                    ||::|..||. |.:
Human    46 LPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEG-LTV 109

  Fly   159 Q---QSPQLIDDAFIFIRRTENGTQF---VEHSPQLLKRLERCFYRSPAAALDLCEPGNVRGVFQ 217
            |   |:|:|:..|       |.||..   :...|:.:..|.             .:.|.:.||.|
Human   110 QYLGQAPELLGGA-------EPGTYLTGTINGDPESVASLH-------------WDGGALLGVLQ 154

  Fly   218 QNGSDLVIHPLP-----ARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFN 277
            ..|::|.:.||.     :..|.|.|:|                  |..||...|
Human   155 YRGAELHLQPLEGGTPNSAGGPGAHIL------------------RRKSPASGQ----------- 190

  Fly   278 EPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSD 342
            .|...::|.....||     :||          |.:|:   |..||        |:||.:..|..
Human   191 GPMCNVKAPLGSPSP-----RPR----------RAKRF---ASLSR--------FVETLVVADDK 229

  Fly   343 LYA-HMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRD 406
            :.| |         .:.:..:||.::......:.||::...::.|:.||.|..|.:....|....
Human   230 MAAFH---------GAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSA 285

  Fly   407 VENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSC 471
            .:. |.|||.||..||...|:||.|:|.|::.|..||.    |.:....:|||.|..:|....||
Human   286 AQT-LRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSC 345

  Fly   472 TINEAKHFESVFVVAHEIGHNLGMRHDAKE--ISCD----PTMHIMSPKLG--SGKVTWSKCSRT 528
            .|.|....:|.|..|||:||...|.||..:  ||.:    .:.|:|:|.:.  ..:..||.||..
Human   346 AIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSAR 410

  Fly   529 YLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRD 593
            ::.|||.:....||.|:.........|    .||:.::|::||.|.||.:              .
Human   411 FITDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPD--------------S 457

  Fly   594 LHCRQDGLP------W------------TSH-PALEGTECGPNMWCRGGTCEARSSKQGSYSALK 639
            .||.|  ||      |            |.| |..:||.|||...|.||.|
Human   458 RHCPQ--LPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC-------------- 506

  Fly   640 SWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRL 704
                .|:.:                 |.|:|     :| ....||.|.....|...|
Human   507 ----LHMDQ-----------------LQDFN-----IP-QAGGWGPWGPWGDCSRTC-------- 536

  Fly   705 LEGSTGLRTLNRSCL-----NFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVC-MQARKSD 763
               ..|::..:|.|.     |....|.||..||.:|||..|   |..:...|..:.| ....::|
Human   537 ---GGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC---PTGSALTFREEQCAAYNHRTD 595

  Fly   764 ------------PELTGEGQQLPSTLDASCKIFCRTRTNG----TKSRRWTFPDGTTCKAKQHNP 812
                        |..||...|      ..||:.|:.:..|    .:.|   ..|||.|     :|
Human   596 LFKSFPGPMDWVPRYTGVAPQ------DQCKLTCQAQALGYYYVLEPR---VVDGTPC-----SP 646

  Fly   813 EDITYCISGRCERFSCD---NSTSNFFKM-----DSSFC--EARSVRPTRDSSDQESRQQTNRQR 867
            :..:.|:.|||....||   .|...|.|.     |.|.|  ::.|.|..|..:...|:....|..
Human   647 DSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRCGTAWGSQLALQRGH 711

  Fly   868 YAERQEGKPQKNHYENEVAKRPSYGQGNH------INAPASPYKRRNYHKPYPPEIPRPP----- 921
            .:.|...:|.......:.|....:....|      :.|||.|:..    .|:.|.:..|.
Human   712 CSLRDTVRPWATGPAFDTASPSGWQPPGHTPPIQLLRAPADPFNA----TPHSPGLAAPKSTDSG 772

  Fly   922 PPASASL 928
            .|::|.|
Human   773 DPSAAPL 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	66/220 (30%)
		ADAMTS_CR_2	561..625	CDD:465496	25/82 (30%)
		TSP1	683..741	CDD:214559	17/62 (27%)
ADAMTS4	NP_001307265.1	Pep_M12B_propep	60..181	CDD:460254	28/141 (20%)
		Cysteine switch. /evidence=ECO:0000250	192..199		1/6 (17%)
		ZnMc_ADAMTS_like	218..425	CDD:239801	67/228 (29%)
		ADAMTS_CR_2	439..507	CDD:465496	26/101 (26%)
		TSP1	531..575	CDD:214559	15/57 (26%)
		ADAMTS_CR_3	578..685	CDD:437068	28/120 (23%)