DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment stl and ADAMTS4

DIOPT Version :9

Sequence 1:NP_001097423.1 Gene:stl / 37619 FlyBaseID:FBgn0086408 Length:1136 Species:Drosophila melanogaster
Sequence 2:NP_001307265.1 Gene:ADAMTS4 / 9507 HGNCID:220 Length:846 Species:Homo sapiens


Alignment Length:917 Identity:219/917 - (23%)
Similarity:317/917 - (34%) Gaps:301/917 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 LPSEDGNGPLPPEEE------------------------------------EQEAGEDVEARLQL 158
            |||.....|||.|||                                    ||::|..||. |.:
Human    46 LPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEG-LTV 109

  Fly   159 Q---QSPQLIDDAFIFIRRTENGTQF---VEHSPQLLKRLERCFYRSPAAALDLCEPGNVRGVFQ 217
            |   |:|:|:..|       |.||..   :...|:.:..|.             .:.|.:.||.|
Human   110 QYLGQAPELLGGA-------EPGTYLTGTINGDPESVASLH-------------WDGGALLGVLQ 154

  Fly   218 QNGSDLVIHPLP-----ARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFN 277
            ..|::|.:.||.     :..|.|.|:|                  |..||...|           
Human   155 YRGAELHLQPLEGGTPNSAGGPGAHIL------------------RRKSPASGQ----------- 190

  Fly   278 EPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSD 342
            .|...::|.....||     :||          |.:|:   |..||        |:||.:..|..
Human   191 GPMCNVKAPLGSPSP-----RPR----------RAKRF---ASLSR--------FVETLVVADDK 229

  Fly   343 LYA-HMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRD 406
            :.| |         .:.:..:||.::......:.||::...::.|:.||.|..|.:....|....
Human   230 MAAFH---------GAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSA 285

  Fly   407 VENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSC 471
            .:. |.|||.||..||...|:||.|:|.|::.|..||.    |.:....:|||.|..:|....||
Human   286 AQT-LRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSC 345

  Fly   472 TINEAKHFESVFVVAHEIGHNLGMRHDAKE--ISCD----PTMHIMSPKLG--SGKVTWSKCSRT 528
            .|.|....:|.|..|||:||...|.||..:  ||.:    .:.|:|:|.:.  ..:..||.||..
Human   346 AIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSAR 410

  Fly   529 YLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRD 593
            ::.|||.:....||.|:.........|    .||:.::|::||.|.||.:              .
Human   411 FITDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPD--------------S 457

  Fly   594 LHCRQDGLP------W------------TSH-PALEGTECGPNMWCRGGTCEARSSKQGSYSALK 639
            .||.|  ||      |            |.| |..:||.|||...|.||.|              
Human   458 RHCPQ--LPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC-------------- 506

  Fly   640 SWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRL 704
                .|:.:                 |.|:|     :| ....||.|.....|...|        
Human   507 ----LHMDQ-----------------LQDFN-----IP-QAGGWGPWGPWGDCSRTC-------- 536

  Fly   705 LEGSTGLRTLNRSCL-----NFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVC-MQARKSD 763
               ..|::..:|.|.     |....|.||..||.:|||..|   |..:...|..:.| ....::|
Human   537 ---GGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC---PTGSALTFREEQCAAYNHRTD 595

  Fly   764 ------------PELTGEGQQLPSTLDASCKIFCRTRTNG----TKSRRWTFPDGTTCKAKQHNP 812
                        |..||...|      ..||:.|:.:..|    .:.|   ..|||.|     :|
Human   596 LFKSFPGPMDWVPRYTGVAPQ------DQCKLTCQAQALGYYYVLEPR---VVDGTPC-----SP 646

  Fly   813 EDITYCISGRCERFSCD---NSTSNFFKM-----DSSFC--EARSVRPTRDSSDQESRQQTNRQR 867
            :..:.|:.|||....||   .|...|.|.     |.|.|  ::.|.|..|..:...|:....|..
Human   647 DSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRCGTAWGSQLALQRGH 711

  Fly   868 YAERQEGKPQKNHYENEVAKRPSYGQGNH------INAPASPYKRRNYHKPYPPEIPRPP----- 921
            .:.|...:|.......:.|....:....|      :.|||.|:..    .|:.|.:..|.     
Human   712 CSLRDTVRPWATGPAFDTASPSGWQPPGHTPPIQLLRAPADPFNA----TPHSPGLAAPKSTDSG 772

  Fly   922 PPASASL 928
            .|::|.|
Human   773 DPSAAPL 779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stlNP_001097423.1 Pep_M12B_propep <155..239 CDD:279848 22/94 (23%)
ZnMc_ADAMTS_like 331..543 CDD:239801 66/220 (30%)
Reprolysin 332..545 CDD:279729 67/221 (30%)
TSP1 683..741 CDD:214559 17/62 (27%)
ADAMTS4NP_001307265.1 Pep_M12B_propep 70..181 CDD:279848 27/131 (21%)
Cysteine switch. /evidence=ECO:0000250 192..199 1/6 (17%)
Reprolysin 218..428 CDD:279729 69/231 (30%)
ZnMc_ADAMTS_like 218..425 CDD:239801 67/228 (29%)
ADAM_CR 438..509 CDD:301627 26/104 (25%)
ADAM_CR 490..659 CDD:301627 54/237 (23%)
TSP1 531..575 CDD:214559 15/57 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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