Protein Alignment stl and ADAMTS10

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_047295436.1
• Gene: ADAMTS10 / 81794
• HGNCID: 13201
• Length: 1152
• Species: Homo sapiens
• Alignment Length: 1185
• Identity: 259/1185 - (21%)
• Similarity: 381/1185 - (32%)
• Gaps: 434/1185 - (36%)

  Fly   134 DGNG------PLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQF---VEHSPQLL 189
            |.||      |.||..:.:..|...|:||              |.:.....|.|   :..|.:||
Human    48 DHNGALLAFSPPPPRRQRRGTGATAESRL--------------FYKVASPSTHFLLNLTRSSRLL 98

  Fly   190 ----------------KRLER--CFY--------RSPAAALDLCEPGNVRGVFQQNGSDLVIHPL 228
                            :|..|  |.|        .|...|:..|  |.:.|:...:..:.:|.||
Human    99 AGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASSSHVAISTC--GGLHGLIVADEEEYLIEPL 161

  Fly   229 ---------PARFGTGTHVLYQ------ARVDKSGGGYSEASSR------RTASPLDSQLQFEPD 272
                     |..  :|.||:|:      ..:|.:.|...|...:      ||..|
Human   162 HGGPKGSRSPEE--SGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKP---------- 214

  Fly   273 AEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAI 337
                 .|.|.|..:::       |.||                  ...||    :..|.::||.:
Human   215 -----PPARPLGNETE-------RGQP------------------GLKRS----VSRERYVETLV 245

  Fly   338 FVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLV 402
            ..|..:.|:       :....|..::||::|.|..|:...:||..:|.::.|| |..:.|.|.|.
Human   246 VADKMMVAY-------HGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRL-ILLTEDQPTLE 302

  Fly   403 RSRDVENYLNSFCKWQEKL-------NPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMAT 460
            .:......|:||||||:.:       |...:....::|.|:::|..|:..|......:  :|:|.
Human   303 ITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT--LGLAP 365

  Fly   461 VKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISC-----DPTMHIMSPKLGSGKV 520
            |.|||....||::||.....:.|.:||||||..||.||....||     ||.      ||.:..:
Human   366 VGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPA------KLMAAHI 424

  Fly   521 T-------WSKCSRTYLEDFLMDPQAECLFD---RDSFAGPWDHTAGGRLPGERFNANQQCMLRF 575
            |       ||.|||.|:..||......||.:   |..|..|   |..   ||:.::|::||..:.
Human   425 TMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYP---TVA---PGQAYDADEQCRFQH 483

  Fly   576 GKNFMQASTQSKM-EICRDLHC--RQDGLPWTSHPALEGTECGPNM----WCRGGTCEARSSKQG 633
            |..    |.|.|. |:|.:|.|  :.:.....|.||.|||.|..:.    ||....|....|:
Human   484 GVK----SRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSR-- 542

  Fly   634 SYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLY 698
                     ||.:..|                                 ||.|:....|...|
Human   543 ---------PEGVDGA---------------------------------WGPWTPWGDCSRTC-- 563

  Fly   699 GQSRRLLEGSTGLRTLNRSCLNFP------SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCM 757
                     ..|:.:.:|.| :.|      ..|:|..||..:|||..|   |..: .||....|.
Human   564 ---------GGGVSSSSRHC-DSPRPTIGGKYCLGERRRHRSCNTDDC---PPGS-QDFREVQCS 614

  Fly   758 QARKSDP---------ELTGEGQQLPSTLDASCKIFCRTR-TNGTKSRRWTFPDGTTCKAKQHNP 812
            :. .|.|         ...|.|.:       :|.:.|... .|....|.....|||.|:     |
Human   615 EF-DSIPFRGKFYKWKTYRGGGVK-------ACSLTCLAEGFNFYTERAAAVVDGTPCR-----P 666

  Fly   813 EDITYCISGRCERFSCDNSTSNFFKM--------DSSFCEA------------------------ 845
            :.:..|:||.|:...||....:..:.        |.|.||.
Human   667 DTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGS 731

  Fly   846 ---------RSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHY------------ENEVAKRP 889
                     .|:.......||||       ...|...|.||.:..            .::|....
Human   732 VHIFIQDLNLSLSHLALKGDQES-------LLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLE 789

  Fly   890 SYGQGN------------------HINAPAS-----PYKRRNYHKPYPPEIPRPPPPASASLI-A 930
            :.|..|                  ..|||.:     ||   ::|  |.|........|..|.: |
Human   790 ALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPY---SWH--YAPWTKCSAQCAGGSQVQA 849

  Fly   931 LDRSSSSESEWVAHPGC--HSN-------CMTDS------KGVQGVTSRL--TGVESIQLCSYRI 978
            ::..:..:|..||...|  ||.       |.|:.      .|...:.||.  .||.|      |.
Human   850 VECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRS------RS 908

  Fly   979 QPCERLQTAAE---YAEQTCARYRQKVRGLSGHG------------AQIS-------------AS 1015
            ..|:|..:|||   ..:..|.:.|..|.. :.||            :::|             .|
Human   909 VVCQRRVSAAEEKALDDSACPQPRPPVLE-ACHGPTCPPEWAALDWSEVSRPLPSRPLGCPGGVS 972

  Fly  1016 IDEPDRSCRVGC-------------QDEF-----------IKYRYYLVNG--RNGHFPPGTRCSP 1054
            .:.|.|..:|.|             :..|           :::|..|...  .....|| ..|||
Human   973 TETPLRGLQVSCPLLTSHWGSTLSTKRPFQLQCTPSCGPGLRHRVVLCKSADHRATLPP-AHCSP 1036

  Fly  1055 VGK----RYCVYGRC 1065
            ..|    ..|...||
Human  1037 AAKPPATMRCNLRRC 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	69/230 (30%)
		ADAMTS_CR_2	561..625	CDD:465496	22/70 (31%)
		TSP1	683..741	CDD:214559	16/63 (25%)
ADAMTS10	XP_047295436.1	Pep_M12B_propep	40..180	CDD:460254	32/149 (21%)
		ZnMc_ADAMTS_like	239..454	CDD:239801	69/230 (30%)
		ADAMTS_CR_2	469..537	CDD:465496	22/71 (31%)
		TSP1	550..602	CDD:214559	17/66 (26%)
		ADAMTS_CR_3	607..705	CDD:437068	24/110 (22%)
		ADAMTS_spacer1	707..818	CDD:461796	13/117 (11%)
		TSP1_ADAMTS	829..884	CDD:465950	14/56 (25%)
		TSP1_ADAMTS	888..944	CDD:465950	17/62 (27%)
		TSP1_ADAMTS	1004..1051	CDD:465950	9/47 (19%)
		TSP1_ADAMTS	1056..1105	CDD:465950
		PLAC	1118..1149	CDD:462560