Protein Alignment stl and ADAMTS12

DIOPT Version :9

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_016865394.1
• Gene: ADAMTS12 / 81792
• HGNCID: 14605
• Length: 1631
• Species: Homo sapiens
• Alignment Length: 847
• Identity: 215/847 - (25%)
• Similarity: 326/847 - (38%)
• Gaps: 206/847 - (24%)

  Fly    75 ALIFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNP------------------ 121
            ||.:| |.|:..|    |....:|       :|....|..|.|...|
Human    23 ALCYG-RQPQPGP----VRFPDRR-------QEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPI 75

  Fly   122 -HQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHS 185
             ..||:|....|||........||     :|:...|.:.|.  .:.:::|..:|..|    :.|.
Human    76 TSSRRKRDLDGSEDWVYYRISHEE-----KDLFFNLTVNQG--FLSNSYIMEKRYGN----LSHV 129

  Fly   186 PQLLKRLERCFY---------RSPAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQ 241
            ..:......|..         |...|||..|.  .:.|.||....|..|.|:.      .|.|.:
Human   130 KMMASSAPLCHLSGTVLQQGTRVGTAALSACH--GLTGFFQLPHGDFFIEPVK------KHPLVE 186

  Fly   242 ARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQ---SQLQSPLRLRFQPRHHH 303
                  ||.:.....||...|            |..||...|:..   ||.|...|.::: ||:.
Human   187 ------GGYHPHIVYRRQKVP------------ETKEPTCGLKDSVNISQKQELWREKWE-RHNL 232

  Fly   304 PHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYA-HMQKNFPTNTESKVVSFLLAMI 367
            |.:...:|              .|.:|.::||.:..|:.:.. |..:|        |.|::|.::
Human   233 PSRSLSRR--------------SISKERWVETLVVADTKMIEYHGSEN--------VESYILTIM 275

  Fly   368 NGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHY 432
            |.|..|:|:|::|..|:.|:.||.:.:. :..||......|..|:||||||:.:||.||.:|:|:
Human   276 NMVTGLFHNPSIGNAIHIVVVRLILLEE-EEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHH 339

  Fly   433 DHALVLTGLDLVT-YDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMR 496
            |.|::||..|:.. :::   ..:.:|::.:.|||....||.|||.......|.:|||:||:.|::
Human   340 DVAVLLTRKDICAGFNR---PCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQ 401

  Fly   497 HDAKEISCDPT---MHIMSPKL--GSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTA 556
            ||.||..|:|.   .:|||.:|  ....:||||||..|:..||......||.|.....|......
Human   402 HDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVI 466

  Fly   557 GGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPWTS-HPALEGTECGPNMWC 620
            .   ||..::.:.||.|::|.|  ....|....:|:.|.|...|...:. ..|.:||:||...||
Human   467 A---PGVIYDVHHQCQLQYGPN--ATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWC 526

  Fly   621 RGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGE 685
            ..|.|.....|           ||.|                                 |..||.
Human   527 MAGKCITVGKK-----------PESI---------------------------------PGGWGR 547

  Fly   686 WSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN----FPSR-CIGRDRRFVTCNTPQCHKVPV 745
            ||..|.|...|           ..|:::..|.|.|    |..: |.|..:|:..||...|.
Human   548 WSPWSHCSRTC-----------GAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCR---- 597

  Fly   746 QTINDFATQVCMQARKSD--PELTGEGQQLPSTLDA-SCKIFCRTRTNGTKSRRW--TFPDGTTC 805
               ::..|...||..:.|  |.........|....| .|:::||. .:|..|.:.  ...|||.|
Human   598 ---SEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRP-IDGQFSEKMLDAVIDGTPC 658

  Fly   806 KAKQHNPEDITYCISGRCERFSCDNSTSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNRQRYAE 870
             .:..|..::  ||:|.|:...||      :::||:..|.|......|.|.    .||.|:.:.:
Human   659 -FEGGNSRNV--CINGICKMVGCD------YEIDSNATEDRCGVCLGDGSS----CQTVRKMFKQ 710

  Fly   871 RQ 872
            ::
Human   711 KE 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	19/92 (21%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	75/218 (34%)
		Reprolysin	332..545	CDD:279729	76/219 (35%)
		TSP1	683..741	CDD:214559	17/62 (27%)
ADAMTS12	XP_016865394.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810