DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and ADGRB1

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_016869180.1	Gene:	ADGRB1 / 575	HGNCID:	943	Length:	1663	Species:	Homo sapiens

Alignment Length:	755	Identity:	143/755 - (18%)
Similarity:	210/755 - (27%)	Gaps:	292/755 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 WSKCSRTYLEDFLMDPQAEC---LFDRDSFAGPWDHTAGGRLPG---ERFNANQQCMLRFGKNFM 580
            |.:|:|            :|   |..|.....|.....||...|   |....|::.....|:
Human   270 WGECTR------------DCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGR--- 319

  Fly   581 QASTQSKMEICRDLHCRQ-----DGL-------PWTSHPALE--------GTECGPNMW------ 619
               |.|:.:..|....|:     |.|       |.|..||.|        .:.||.. |
Human   320 ---TSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEG-WQTRTRF 380

  Fly   620 ---------CRGGTCEARSSKQGS----YSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNP 671
                     |.|...|.|.....:    :.|...|.|..:..:|..:..|.......|.....||
Human   381 CVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNP 445

  Fly   672 MDNE-----------LPGS--PSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPS 723
            .:..           .||.  ..||.|||..|||.:.|..|:.:|           .|.| |.||
Human   446 CEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQR-----------TREC-NGPS 498

  Fly   724 ----RCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIF 784
                .|.|.......|...||   ||.                     |:.|...|.  .||.:.
Human   499 YGGAECQGHWVETRDCFLQQC---PVD---------------------GKWQAWASW--GSCSVT 537

  Fly   785 CRTRTNGTKSRR------WTFPDGTTCKAKQHNPEDITYCISGRC----ERFSCDNSTSNFFKMD 839
            |     |..|:|      ..|..|..|:..|   ::...|.:.||    |....||..:..:| :
Human   538 C-----GAGSQRRERVCSGPFFGGAACQGPQ---DEYRQCGTQRCPEPHEICDEDNFGAVIWK-E 593

  Fly   840 SSFCEARSVRPTRD----------------------------SSDQESRQQTNRQRYAERQEGKP 876
            :...|..:||..|:                            |.|..:.|...|:..|:.|.|.|
Human   594 TPAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLP 658

  Fly   877 QKNHYE-----NEVAKRPSYGQGNHINA-----PASPYKRRNYHKPYPPEIPRPPPPASASLIAL 931
            .:...|     .|:::..:...|:.::.     ..:...||.|:.|.|.::.......| :|:|.
Human   659 GEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILS-NLLAE 722

  Fly   932 DRSSSSESEWVAHPGCHSNC-------------MTDSKGVQGVTSRL---------TGVESIQLC 974
            :.....|...:|.|......             |.|.:....||..|         :|...|..
Human   723 ENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISF- 786

  Fly   975 SYRIQPCERLQTAAEYAEQTCAR---------------------------YR------------- 999
                 |.:..:...::|:....|                           ||
Human   787 -----PMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTT 846

  Fly  1000 ---QKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCV 1061
               .||         ||.::..|.||.|...:.||.    ::.||....
Human   847 VLNSKV---------ISVTVKPPPRSLRTPLEIEFA----HMYNGTTNQ---------------- 882

  Fly  1062 YGRCLEFGDDDLPLDKTHISLG-------------QLRTR 1088
              .|:.:.:.|:|.......||             .||||
Human   883 --TCILWDETDVPSSSAPPQLGPWSWRGCRTVPLDALRTR 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	4/23 (17%)
		Reprolysin	332..545	CDD:279729	5/25 (20%)
		TSP1	683..741	CDD:214559	19/61 (31%)
ADGRB1	XP_016869180.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900