DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stl and ADAMTSL3

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_011520124.1	Gene:	ADAMTSL3 / 57188	HGNCID:	14633	Length:	1718	Species:	Homo sapiens

Alignment Length:	368	Identity:	87/368 - (23%)
Similarity:	125/368 - (33%)	Gaps:	86/368 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   630 SKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPS-ACE 693
            |.|||:          :.:.|.|:.:.:   |...........|.:..|:...||:||:.| .|.
Human    41 SPQGSF----------LEDTTGEQFLTY---RYDDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCG 92

  Fly   694 SGCLYGQSRRLLEGSTGLRTLNRSCLNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQ 758
            .|..| ..||.|.|               ..|.|::.|:.||:...|   |... .||..|.|
Human    93 GGASY-SLRRCLTG---------------RNCEGQNIRYKTCSNHDC---PPDA-EDFRAQQC-- 135

  Fly   759 ARKSDPELTGEGQQ-LPSTLD--ASCKIFCRTR-TNGTKSRRWTFPDGTTCKAKQHNPEDITYCI 819
            :..:|.:..|...: ||...|  |.|.:.|..: .|..........|||.|     |.:.:..||
Human   136 SAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRC-----NTDSLDMCI 195

  Fly   820 SGRCERFSCDNSTSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENE 884
            ||.|:...||....:..|.|:  |   .|.....|:.:..|.|:......|:..|.|
Human   196 SGICQAVGCDRQLGSNAKEDN--C---GVCAGDGSTCRLVRGQSKSHVSPEKTPGLP-------- 247

  Fly   885 VAKRPSYG---QGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESEWV---A 943
                |..|   .|.|::|        .|..|.        .....::||:...|.|....|   |
Human   248 ----PGQGGPLPGGHLSA--------IYEWPI--------LKGEENVIAVPLGSRSVRITVKGPA 292

  Fly   944 HPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQT 986
            |....|..:..|||.....|  .||..::..:...|.....||
Human   293 HLFIESKTLQGSKGEHSFNS--PGVFLVENTTVEFQRGSERQT 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801
		Reprolysin	332..545	CDD:279729
		TSP1	683..741	CDD:214559	17/58 (29%)
ADAMTSL3	XP_011520124.1	TSP1	78..124	CDD:214559	18/64 (28%)
		TSP1	453..>473	CDD:214559
		TSP1	513..>542	CDD:214559
		TSP1	598..>618	CDD:214559
		TSP1	734..787	CDD:214559
		TSP1	790..847	CDD:214559
		TSP1	853..908	CDD:214559
		Ig	956..1020	CDD:299845
		Ig	1238..1302	CDD:143165
		IG_like	1336..1410	CDD:214653
		IGc2	1341..1401	CDD:197706
		TSP_1	1516..1571	CDD:301595
		PLAC	1686..1716	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810