DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and wfikkn2b

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_699239.1	Gene:	wfikkn2b / 570642	ZFINID:	ZDB-GENE-110414-1	Length:	563	Species:	Danio rerio

Alignment Length:	476	Identity:	92/476 - (19%)
Similarity:	140/476 - (29%)	Gaps:	183/476 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   511 MSPKLGSGKVTW----SKCSRTYLEDFLMDPQAECLFD----RDSFAGPWDHTAGGR----LPGE 563
            |:|.|      |    |.|.|....|...:|..:|..:    |...|..:..|.|.:    :|.|
Zfish    47 MNPNL------WVDAMSTCKRECQTDQECEPLEKCCANVCGSRSCVAARYIDTTGKKGPMGMPKE 105

  Fly   564 ----RFNANQQ---CMLRFGKNFMQASTQSKMEICRD-------LHCRQDGLPWTSHPALEGTEC 614
                :|...||   |.:|.|:...:         |||       ..|..||:.:.:...::...|
Zfish   106 ASCDQFMCTQQGSECDIRDGQPVCK---------CRDRCEREPQFTCASDGMTYYNKCYMDAEAC 161

  Fly   615 GPNMWCRGGTCEARSSKQGSYSALK-----SWP-PEHIPEAT----------------HEKIIRH 657
                           ||..|.|.:.     ||| |..:|..|                ...:|..
Zfish   162 ---------------SKGISLSVVSCRFHLSWPNPSPLPSGTTALPTTALQITTPVQMQAPVILS 211

  Fly   658 EPNRIPPLLHDYNPMDNELPGSP---SNWGEWSEPSACESGCLYGQ------SRRLLEGS----T 709
            .|.:....:.|......::.|.|   ..|.:.||....:...:||.      .:.::..:    :
Zfish   212 SPTQQSASIGDTVSFLCDVVGHPVPEITWQKQSESVHMKPNQVYGNVVVTNIGQLVIYNAQVQDS 276

  Fly   710 GLRTLNRS------CLNFPSRCIGRDRRFVTCN-----TPQCHKVP-----------------VQ 746
            |:.|...:      ..||| ..:.:....|..|     ..:|.|.|                 ..
Zfish   277 GIYTCTAANAGGSVQANFP-LSVSKPEAVVQVNASAVPVDECFKAPDSDDCGEEKLSWFFDPQRN 340

  Fly   747 TINDFATQVCMQARK--SDPEL--------TGEGQQLP----------------STLDASCKIF- 784
            :.|.|..:.|...|.  .|.|.        ......||                |||. .|::|
Zfish   341 SCNTFTYRNCSSNRNHFDDYESCMSSCLLNISASCMLPIHKGPCKAYELRWAYSSTLH-QCRLFI 404

  Fly   785 ---CRTRTNGTKSRR-----WTFPDGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNFFKMDSS 841
               |:...|..||:|     ..:|....|||.:..                        :||.||
Zfish   405 YGGCKANENNFKSKRSCEDACPYPKNHQCKACKPR------------------------YKMVSS 445

  Fly   842 FCEARSV---RPTRDSSDQES 859
            ||.:..|   |....:.||:|
Zfish   446 FCRSDFVILGRMVDLTEDQDS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	10/35 (29%)
		Reprolysin	332..545	CDD:279729	10/41 (24%)
		TSP1	683..741	CDD:214559	12/78 (15%)
wfikkn2b	XP_699239.1	WAP	41..87	CDD:278522	11/45 (24%)
		KAZAL_FS	135..171	CDD:238052	8/50 (16%)
		I-set	207..298	CDD:254352	15/91 (16%)
		Ig	221..298	CDD:299845	13/77 (17%)
		Kunitz_BPTI	317..367	CDD:278443	9/49 (18%)
		Kunitz_BPTI	375..425	CDD:278443	12/50 (24%)
		NTR_like	443..551	CDD:295338	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900