Protein Alignment stl and adamts6

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_017213499.1
• Gene: adamts6 / 569099
• ZFINID: ZDB-GENE-091113-9
• Length: 1116
• Species: Danio rerio
• Alignment Length: 1028
• Identity: 238/1028 - (23%)
• Similarity: 362/1028 - (35%)
• Gaps: 317/1028 - (30%)

  Fly   110 RPGEAEQHGGNPHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEAR-------------LQLQQS 161
            |||            |:||.|              :|...:..|.|             |.|..:
Zfish    62 RPG------------RRRRGL--------------DQTELDHTETRLFYKLSAYGKHFHLNLTLN 100

  Fly   162 PQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCF--------YRSPAAALDLCEPGNVRGVFQQ 218
            |.|:...|......::|..: :||.     ::.|.        |.:...||..|:  .:.||...
Zfish   101 PNLVSKHFTVEYWGKDGLDW-QHSV-----VDNCHYVGYLLDQYSTTKVALSNCK--GLHGVITT 157

  Fly   219 NGSDLVIHPL--------PARFGTGTHVLY--------QARVDKSGGGYSEASSRRTASPLDSQL 267
            .....:|.||        ........||:|        |....:...|.|:.:..||
Zfish   158 EDEQYLIEPLKNISRNFSDVNHEGQPHVIYKKTSIPSPQEPSKEFSCGVSDLTVNRT-------- 214

  Fly   268 QFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELF 332
            ||.....:.|.....|...|.:.:                |:|||             .:..|.|
Zfish   215 QFYNTNPKLNPDFPVLGVDSLMGA----------------HRQRR-------------SVSSERF 250

  Fly   333 IETAIFVDSDLYA-HMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSW 396
            :||.:..|..:.. |.:|:        :..::|:::|.|..||...:||..:|.::.|| |..:.
Zfish   251 VETLVVADKMMVGYHGRKD--------IEHYILSVMNIVAKLYRDASLGNVVNIIVTRL-IVLTE 306

  Fly   397 DPPGLVRSRDVENYLNSFCKWQEKL-------NPFSDADPLHYDHALVLTGLDLVTYDKGKANSQ 454
            |.|.|..:...:..|:||||||:.:       |...:....|:|:|:::|..|:.||......:
Zfish   307 DQPNLEINHHADKSLDSFCKWQKSILSHQGDGNSIPENGIAHHDNAVLITRYDICTYKNKPCGT- 370

  Fly   455 VVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGK 519
             :|:|:|.|||....||:|||.....|.|.:|||||||.||.||....||....| .:.||.:..
Zfish   371 -LGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGH-ETAKLMAAH 433

  Fly   520 VT-------WSKCSRTYLEDFLMDPQAECL----FDRDSFAGPWDHTAGGRLPGERFNANQQCML 573
            :|       ||.||:.|:..||...:..||    ..|| |..|   |..   ||:.::|::||..
Zfish   434 ITANTNPFSWSACSKDYITSFLDSGRGTCLDNEPLKRD-FLYP---TVA---PGQVYDADEQCRF 491

  Fly   574 RFGKNFMQASTQSKM-EICRDLHC--RQDGLPWTSHPALEGTECGPNM----WCRGGTCEARSSK 631
            ::|    .:|.|.|. |:||:|.|  :.:.....|.||.|||.|..|.    ||..|.|
Zfish   492 QYG----ASSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTNTIEKGWCYQGEC------ 546

  Fly   632 QGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGC 696
                .|..:||                               ..:.||   ||.|:
Zfish   547 ----VAFGTWP-------------------------------QSVDGS---WGPWT--------- 564

  Fly   697 LYGQSRRLLEGSTGLRTLNRSCLN-FPS----RCIGRDRRFVTCNTPQCHKVPVQTINDFATQVC 756
            ::|:..|...|  |:.:..|.|.: .||    .|:|..:|:.:|||..|    .:...||..:.|
Zfish   565 VWGECSRTCGG--GVSSSMRHCDSPAPSGGGKYCLGERKRYRSCNTDAC----PEGSRDFREKQC 623

  Fly   757 MQARKSDP---------ELTGEGQQLPSTLDASCKIFCRTR-TNGTKSRRWTFPDGTTCKAKQHN 811
            ... .|.|         ..||.|.:       .|.:.|... .|....|.....|||.|:.
Zfish   624 ADF-DSLPFRGKYYNWKPYTGGGVK-------PCALNCLAEGYNFYTERSPAVIDGTRCQG---- 676

  Fly   812 PEDITYCISGRCERFSCDNSTSNFFKM--------DSSFCEARSVRPTRDSSDQESRQQTNRQRY 868
             :.:..||:|.|:...|||...:..|.        |.|.||.         ::........|..|
Zfish   677 -DSLDICINGECKHVGCDNILGSDAKEDRCRVCGGDGSTCEL---------TEGLFNDSLPRGGY 731

  Fly   869 AERQEGKPQKNHYE-NEVAKRPSY------GQGNHIN-APASPYKRR------NYHKPYPPEIPR 919
            .|..:......|.| .|||...:|      |...:|| |....:.|:      .:|...|.:.|.
Zfish   732 MEVVQIPKGSVHIEIREVAVSKNYIALKSEGDDYYINGAWTIDWPRKFDIAGTAFHYKRPTDEPE 796

  Fly   920 PPPPASASL---------------------IALDRSSSSESE----WVAHP--GCHSNCMTDSKG 957
            ......|::                     :.:.|:.|.::|    |...|  .|.:.|...|:.
Zfish   797 SLEALGATMENLVVMVLLQEQNLGIQYKFNVPIQRTGSGDNEVGFSWHHLPWSECSATCAGGSQK 861

  Fly   958 VQGVTSRLTGVESIQ--LCSY-----------RIQPCERLQTAAEYAE--QTC 995
            .:.|..||.....:|  .|..           ..:||.......:::|  :||
Zfish   862 QEVVCKRLDDNSVVQNSYCDQDSKPPGNQRRCNTEPCPPEWFIGDWSECGKTC 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	74/230 (32%)
		ADAMTS_CR_2	561..625	CDD:465496	25/70 (36%)
		TSP1	683..741	CDD:214559	17/62 (27%)
adamts6	XP_017213499.1	Pep_M12B_propep	40..187	CDD:460254	30/158 (19%)
		ZnMc_ADAMTS_like	249..464	CDD:239801	73/226 (32%)
		ADAMTS_CR_2	479..547	CDD:465496	26/81 (32%)
		TSP1	560..612	CDD:214559	18/66 (27%)
		ADAMTS_CR_3	617..715	CDD:437068	26/110 (24%)
		ADAMTS_spacer1	719..828	CDD:461796	18/108 (17%)
		TSP1_ADAMTS	843..898	CDD:465950	10/54 (19%)
		TSP1_ADAMTS	902..958	CDD:465950	3/13 (23%)
		TSP1_ADAMTS	962..1016	CDD:465950
		TSP1_ADAMTS	1021..1070	CDD:465950
		PLAC	1082..1114	CDD:462560