DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adamts1

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_021331598.1	Gene:	adamts1 / 565145	ZFINID:	ZDB-GENE-070814-1	Length:	1026	Species:	Danio rerio

Alignment Length:	958	Identity:	224/958 - (23%)
Similarity:	335/958 - (34%)	Gaps:	305/958 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 PEEEEQEAGEDVEAR------------LQLQQSPQLIDDAFIF--IRRTENGTQFVEHSPQLLKR 191
            |...:|...||.|.|            |.|:.....:...|:|  :.:.|.| :|.....
Zfish    38 PGHTKQSREEDSEKRIYRLDVFGKRMVLALEPDQTFLAPGFVFQMVGKPETG-EFDSAGE----- 96

  Fly   192 LERCFYRS-------PAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGG 249
             .|||:..       .:||::||:  .:.|.|...|.:..|.|   ...||      |..|:.
Zfish    97 -ARCFFSGTVNGDELSSAAINLCK--GLHGGFSVGGEEYFIQP---ENSTG------AATDRD-- 147

  Fly   250 GYSEASSRRTASPLDSQLQFEPDAEE------FNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQ-- 306
              :....|||...|         |||      .||...|:     .:.|     ...|..|.:
Zfish   148 --THTIRRRTPGIL---------AEESGSKCGVNEEEERV-----TEKP-----HTTHSKPSESK 191

  Fly   307 -HHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGV 370
             ||  |.||:: ..||          ::|..|..|..: |...       .:::..:||.::...
Zfish   192 AHH--RSRRFV-STPR----------YLEIMIVADQSM-AEFH-------GAQLKPYLLTIMAVA 235

  Fly   371 QLLYHHPTLGRRINF-VLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDH 434
            ..||.|||:...|.. |:|.|.:......|.:  |.:....|.|||:||::.|..||..|.|||.
Zfish   236 SRLYRHPTIHNSITLAVVKLLVVHDEEHGPHV--STNAALTLRSFCQWQKQHNQPSDRHPEHYDT 298

  Fly   435 ALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRH-D 498
            |::.|..||.    |..:...:|||.|...|....||:|.|....::.|.||||:||...|.| |
Zfish   299 AVLFTRKDLC----GAHSCDTLGMADVGTACDPDRSCSIIEDDGLQAAFTVAHELGHVFNMPHDD 359

  Fly   499 AKE---ISCDP-TMHIMSPKLGSGKV--TWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAG 557
            ||:   ::.|. ..|:|:..|.:...  .||.||...:..||.:...:||.|:.........|
Zfish   360 AKQCASVNGDQWGAHMMASTLSNLNQLDPWSPCSALMVTSFLDNGHGQCLLDKPQKPEELPQT-- 422

  Fly   558 GRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLH------------------CRQDGLPWT 604
              |||..::|::||.|.||:         :.:.|.||.                  |:....||.
Zfish   423 --LPGSVYDADRQCRLTFGE---------ESQHCPDLSSTCAALWCTVTSANGLLVCQTKNFPWA 476

  Fly   605 SHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDY 669
                 :||.||.|.:|..|.|.:::.                 .|.:|
Zfish   477 -----DGTPCGSNSYCMAGQCLSKTE-----------------AAKYE----------------- 502

  Fly   670 NPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPSR-----CIGRD 729
            .|::    |...:||.|.:   |...|           ..|::...|.|:|...:     |.|:.
Zfish   503 TPVN----GGWGSWGSWGD---CSRTC-----------GGGVQYSFRDCVNPRPKNGGKYCEGKR 549

  Fly   730 RRFVTCNTPQCHKVPVQTI--------NDFATQVCMQARKSDPELTGEG-QQLPSTLDAS----C 781
            .::.:|||..|......|.        ||.::||.:.        :||| :.:|.....|    |
Zfish   550 IQYRSCNTETCPDSNGLTFREEQCLAHNDLSSQVSLG--------SGEGVEWVPKYAGVSPKDRC 606

  Fly   782 KIFCRTRTNG----TKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCD---NSTSNFFKM- 838
            |:.||.:..|    .|.:   ..|||.|     .|:..:.|:.|:|.:..||   .|...|.|.
Zfish   607 KLVCRAKGTGYFFILKPK---VADGTPC-----TPDSTSVCVQGQCVKAGCDRVIGSDKRFDKCG 663

  Fly   839 ----DSSFCEARS-----VRP------------TRDSSDQES---RQQTNRQRYAERQEGKPQKN 879
                |.|.|:..|     .||            |.....|.|   |.|.|......||:|....|
Zfish   664 ICGGDGSTCKKVSGSMERARPGYQDVVTIPAGATHLDVKQRSFGGRSQDNSYLAVRRQDGSYLLN 728

  Fly   880 ------HYENEVAKR------------------------PSYGQGNHINAPASPYKRRNYHKPYP 914
                  ..|.:::.:                        |...|...:.....|..:.:|..|.|
Zfish   729 GDYKLTTLETDISVKGALLRYSGSSVLLERLRSFAPLPEPLTIQVLSVGESPRPRVKYSYFAPRP 793

  Fly   915 PEIPRPPPPASASLIALDRSSSSE---SEWVAHPGCHSNCMTDSKGVQ 959
            ....||      |:.|:.::..:|   .||..   |...|   ..|:|
Zfish   794 NGSNRP------SINAISKAVDAEWFLGEWGT---CSKTC---GGGIQ 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	22/104 (21%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	67/219 (31%)
		Reprolysin	332..545	CDD:279729	68/220 (31%)
		TSP1	683..741	CDD:214559	14/62 (23%)
adamts1	XP_021331598.1	Pep_M12B_propep	29..136	CDD:307618	24/106 (23%)
		ZnMc_ADAMTS_like	204..410	CDD:239801	68/229 (30%)
		ADAM_CR	423..495	CDD:326582	23/85 (27%)
		TSP1	517..561	CDD:214559	11/57 (19%)
		ADAM_spacer1	673..791	CDD:310520	18/117 (15%)
		TSP1	811..864	CDD:214559	7/25 (28%)
		TSP1	869..917	CDD:214559
		TSP1	922..970	CDD:214559
		TSP1	972..1026	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910