DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adgrb1a

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_009290826.1	Gene:	adgrb1a / 563527	ZFINID:	ZDB-GENE-060607-12	Length:	1610	Species:	Danio rerio

Alignment Length:	675	Identity:	131/675 - (19%)
Similarity:	202/675 - (29%)	Gaps:	265/675 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   517 SGKVTWSKCS---------RT----------YLEDFLMDPQAECLFDRDSFAGPWDHTAGGR-LP 561
            ||...|::||         ||          ||.:.:::....|  :.....|...:::.|: |.
Zfish   243 SGWGNWAECSSECGGGVQKRTRNCQSPPDEAYLCEGVLEEGRPC--NAQPCIGYRQYSSKGQGLS 305

  Fly   562 GERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQD------------------GLPWTSHPA 608
            ..::...|:.||  ||..:.:.:||...:  |...|:|                  |..|::...
Zfish   306 PVKYKGMQEAML--GKGRLGSRSQSLRSV--DSRKREDSDKTRSGQQSSQTVDSPSGEEWSAWSV 366

  Fly   609 LEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMD 673
            ...| ||     .|.....|.....|||...|.|                       |.:..|.:
Zfish   367 CSAT-CG-----EGWQSRTRFCVSVSYSTQCSGP-----------------------LREQRPCN 402

  Fly   674 N------ELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPSR-----CIG 727
            |      .|......||||:..|.|.|.|           ..|.|..||||.  |.:     |.|
Zfish   403 NTAVCPAALITEHGAWGEWTPWSLCSSTC-----------GRGYRERNRSCK--PPQFGGNPCDG 454

  Fly   728 RDRRFVTCNTPQCHKVPVQTI-NDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNG 791
            .:::...||...|   ||..: |:::..                        :||...|   :||
Zfish   455 PEKQTKFCNIAVC---PVDGVWNEWSGW------------------------SSCSSTC---SNG 489

  Fly   792 T--KSRRWTFPD--GTTCKAKQHNPED--ITYC-ISGRCERFS----CDNSTSNFFKMDSSFCEA 845
            |  :.|....|.  |..|:.:.|...|  :..| :.|:.:.:|    |..:.....:.....|..
Zfish   490 TMQRIRECNGPSYGGLECQGEWHETRDCFLRECPVDGQWQLWSTWSGCTKTCGGGSQQRQRLCYG 554

  Fly   846 RSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYH 910
            ..........|:|..::.|.:|..|..|...::| :.|.|.|:...|....:..
Zfish   555 PFFGGEACPGDREEVRRCNEKRCPEPHEICDEEN-FSNVVWKKTPAGDTAAVRC----------- 607

  Fly   911 KPYPPEIPRPPPPASASLIALDRSSSSESEWVA------HPGCHSNCMTDSKGVQGVTSRLTGVE 969
                       ||.:..||.  |..|.::|.:|      :..|.||   |.:.:|.:|.
Zfish   608 -----------PPNAVGLIL--RRCSLDNEGIAYWENPTYMKCVSN---DYRSIQTLTR------ 650

  Fly   970 SIQLCSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKY 1034
                        :.|..|.              |||.|.|      :.|.....||...|
Zfish   651 ------------DHLSKAQ--------------RGLVGDG------VSEVMTKLRVTSSD----- 678

  Fly  1035 RYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQLRTRRKRSSISNDLF 1099
                          ||..|               ||                    ..:|.:.|.
Zfish   679 --------------GTSYS---------------GD--------------------LLAIIDVLK 694

  Fly  1100 NITEIFIKPSHSDISAENIEFTQPI 1124
            |:||||.:..:|..:|:...|.|.:
Zfish   695 NMTEIFRRSYYSPSNADMRNFVQSV 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	10/44 (23%)
		Reprolysin	332..545	CDD:279729	10/46 (22%)
		TSP1	683..741	CDD:214559	19/62 (31%)
adgrb1a	XP_009290826.1	TSP1	242..291	CDD:214559	10/49 (20%)
		TSP1	360..408	CDD:214559	14/76 (18%)
		TSP1	418..468	CDD:214559	20/65 (31%)
		TSP1	473..523	CDD:214559	13/76 (17%)
		TSP1	528..578	CDD:214559	7/49 (14%)
		HRM	580..646	CDD:295297	18/93 (19%)
		GAIN	665..860	CDD:293098	20/109 (18%)
		GPS	886..930	CDD:280071
		7tm_4	944..1211	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900