DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and cfp

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001153598.1	Gene:	cfp / 556399	ZFINID:	ZDB-GENE-030131-9247	Length:	437	Species:	Danio rerio

Alignment Length:	507	Identity:	101/507 - (19%)
Similarity:	153/507 - (30%)	Gaps:	190/507 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 GMCTSIYS------CTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGKVT 521
            |.|..:..      |.||.:..|.....|....||                      ...|...:
Zfish    34 GKCADLLGEIEKDFCCINPSYGFAEADGVCRSCGH----------------------AAWSEWSS 76

  Fly   522 WSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQS 586
            ||:||.:..|.  :..:....:...:.:.|.|                           ..:.|:
Zfish    77 WSQCSVSCTEG--VTQRRRFCYGNGNCSDPED---------------------------LGTIQT 112

  Fly   587 KMEICRDLHCRQDGLPWTS----HPALEGTECG----------PNMWCRGGTCEARSSK------ 631
            |..:.:|. |.:|| .|:.    .|.....|.|          |...| ||:|.....:
Zfish   113 KPCVKKDC-CPEDG-GWSKWGNWQPCSVTCENGQKKRQRACSNPAPKC-GGSCSGEPQEIEPCSA 174

  Fly   632 ------QGSYSALKSW---PPEHIPEATH-EKIIR------HEPNRIPP------LLHDYNPMDN 674
                  .|.:|...:|   |...|.|..: :|.:|      ..|:..||      ...|..|...
Zfish   175 DTVCPTHGGWSTWGNWGRCPVTCIEEGRNTQKEVRTRTCTNPSPSTAPPGRFCEGSEKDTRPCSG 239

  Fly   675 ELPGSP--SNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPS------RCIGRDRR 731
             ||..|  .:||.||..|||...|           ..|.:..:|.| :.||      .|.|.:::
Zfish   240 -LPFCPIDGSWGSWSGSSACSVTC-----------GVGRQMQSRIC-DSPSPKHGGKPCHGIEQK 291

  Fly   732 FVTCNTPQCHKVPVQ-TINDFAT-QVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKS 794
            ...|.|  ..|.|:. ...:::. .:|    ||           |||.    ||.||||
Zfish   292 SGLCRT--LAKCPIHGRWTEWSEWSIC----KS-----------PSTR----KITCRTR------ 329

  Fly   795 RRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCDNST---SNFFKMDSSFCEARSVRP------ 850
                  :||..|.:.        |:....|...||...   .:.|.:|.  |:..::..
Zfish   330 ------EGTRRKLRD--------CVGTEHEGKLCDGEIVEHGSCFDIDK--CDMEAILSEWSEWS 378

  Fly   851 -TRDSSDQESRQQTNRQRYAERQE----------GKPQKN--HYENEVAKRP 889
             .:....|:|:|..:|:...:..|          |||..|  ..::|...||
Zfish   379 YCKPDCGQDSKQTRSRKCVPDISEYQSDDYSLFYGKPVINCEKVKDETETRP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	15/85 (18%)
		Reprolysin	332..545	CDD:279729	15/87 (17%)
		TSP1	683..741	CDD:214559	17/63 (27%)
cfp	NP_001153598.1	TSP_1	72..120	CDD:278517	10/76 (13%)
		TSP1	127..179	CDD:214559	9/52 (17%)
		TSP_1	<184..243	CDD:301595	14/59 (24%)
		TSP1	257..302	CDD:214559	13/58 (22%)
		TSP_1	<362..437	CDD:301595	14/71 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960