DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and CFP

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001138724.1	Gene:	CFP / 5199	HGNCID:	8864	Length:	469	Species:	Homo sapiens

Alignment Length:	459	Identity:	101/459 - (22%)
Similarity:	144/459 - (31%)	Gaps:	170/459 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 PFSDADPLHYDHALVLTGLDLVTYDK--GKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVV 485
            |.:.:||:          |....|::  ||....:.|..:|:       .|.:|.|      |..
Human    23 PATGSDPV----------LCFTQYEESSGKCKGLLGGGVSVE-------DCCLNTA------FAY 64

  Fly   486 AHEIGHNLGMRHDAKEISCDPTMHIMSPK--LGSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSF 548
            ....|   |:        |.|   ..||:  |.|   ||:.||.|..|
Human    65 QKRSG---GL--------CQP---CRSPRWSLWS---TWAPCSVTCSE----------------- 95

  Fly   549 AGPWDHTAGGRLPGER-FNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQD-------GLPW-- 603
                    |.:|...| ...|.||.   || ....:.:.:::.|.|..|..:       | ||
Human    96 --------GSQLRYRRCVGWNGQCS---GK-VAPGTLEWQLQACEDQQCCPEMGGWSGWG-PWEP 147

  Fly   604 ---------------TSHPALEGTECGPNMWCRGGTCEARSSKQ-----GSYSALKSWPP----- 643
                           .:|||   .:||.:...:....||..::|     |:::....|.|
Human   148 CSVTCSKGTRTRRRACNHPA---PKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASC 209

  Fly   644 ---EHIPEATH-EKIIRHEPNRIPP------LLHDYNPMDNELPGSP--SNWGEWSEPSACESGC 696
               .|.|:.|. .|....||::.||      |.::...... ||..|  ..||.|...|.|...|
Human   210 HGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTG-LPPCPVAGGWGPWGPVSPCPVTC 273

  Fly   697 LYGQSRRLLEGSTGLRTLNRSCLNFP------SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQV 755
            ..||:..           .|:| |.|      ..|.|...|...|||    .||...
Human   274 GLGQTME-----------QRTC-NHPVPQHGGPFCAGDATRTHICNT----AVPCPV-------- 314

  Fly   756 CMQARKSDPELTGEGQQLP----STLDASCKIFCRTRTNGTKSRRWTFPDGTTCKAKQHNPEDIT 816
                   |.|....|:..|    :....||:.....::.|...|...| ||..|..:|   :||.
Human   315 -------DGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKF-DGHRCAGQQ---QDIR 368

  Fly   817 YCIS 820
            :|.|
Human   369 HCYS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	27/123 (22%)
		Reprolysin	332..545	CDD:279729	27/125 (22%)
		TSP1	683..741	CDD:214559	18/63 (29%)
CFP	NP_001138724.1	TSP_1	81..132	CDD:306574	18/82 (22%)
		TSP_1	140..184	CDD:306574	9/47 (19%)
		TSP1	196..255	CDD:214559	13/59 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..238		6/18 (33%)
		TSP_1	261..312	CDD:306574	18/66 (27%)
		Interaction with Compliment C3 beta chain. /evidence=ECO:0000269\|PubMed:28264884, ECO:0000269\|PubMed:31507604	351..359		4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960