DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and AdamTS-A

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster

Alignment Length:	1085	Identity:	225/1085 - (20%)
Similarity:	377/1085 - (34%)	Gaps:	325/1085 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 EARLQLQQSPQLI-DDAFIFIRRTENGTQFVEH-SPQLLKRLER----CFYRS-------PAAAL 204
            :..|.|:|....: :.:...||..:.|.   || .|:.....|:    |||..       ...::
  Fly   304 QLHLVLRQDASFVHNHSMTHIRILKEGE---EHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVSV 365

  Fly   205 DLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQF 269
            .||  |.:.|..:.:...|:|.|:...  :...||:  ||.:.    |:.::|...|      :|
  Fly   366 SLC--GGMTGYIKTSFGALLIQPVNRT--SSDEVLH--RVFRK----SQRNARHAVS------KF 414

  Fly   270 EPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELF-I 333
            |...::|.....:::.:.|.....:|..:.||                      ::|:..::: :
  Fly   415 ELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRH----------------------YADVDNQVYTL 457

  Fly   334 ETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDP 398
            |..|.||:.:     |.|........:..|:::::.:   :...::|..|..:|.||....:.:.
  Fly   458 EVLIAVDNSM-----KQFHGEDLQPYILILMSIVSSI---FADASIGNSIRILLVRLISLPNIND 514

  Fly   399 PGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKG 463
                ::......|..||:       |.:......|.|:::|...:.....||. ..::|:|.:..
  Fly   515 ----QTHSSNEMLKHFCQ-------FINQSGYERDTAMLITREPICGSVPGKI-CHMLGLAELGT 567

  Fly   464 MCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDP---------TMHIMSPKLG--S 517
            :|:| .||:|.:.....:.|.:|||:||.|.|.||..: .|.|         .:||||..:|  .
  Fly   568 VCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDD-KCMPYVTRQNNNKVLHIMSSVMGIHM 630

  Fly   518 GKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGG--RLPGERFNANQQCMLRFGKNFM 580
            ...:||||||.::.:||......||   ::..|.  |...|  |||||.::.:.||.|.||.:|.
  Fly   631 HPWSWSKCSRHFVSEFLEKTDKSCL---ETSVGA--HIPYGTERLPGEIYSLDAQCQLSFGNDFG 690

  Fly   581 QASTQSKMEICRDL-----------HCRQDGLPWTSHPALEGTECGPN-MWCRGGTCEARSSKQG 633
            ...|.   |.|:.|           .|....|||.     :||.||.: .||:.|.|.:..
  Fly   691 YCPTD---EECKRLWCNRTSGNSNEQCASSNLPWA-----DGTPCGSSGHWCQRGKCVSNK---- 743

  Fly   634 SYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLY 698
                                             |.|....|      ..||.|:..:.|...|
  Fly   744 ---------------------------------HGYGRQVN------GGWGPWTPFTPCSLTC-- 767

  Fly   699 GQSRRLLEGSTGLRTLNRSCLNFP------SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVC- 756
                     ..|::...|.| |.|      ..|.|..:::.:|||.||   |..:: |...|.|
  Fly   768 ---------GGGVQESRREC-NQPVPENGGKYCTGSRKKYRSCNTHQC---PPGSM-DPREQQCY 818

  Fly   757 -MQARKSD-PELTGEGQQLPSTLDASCKIFCRTRTNGT----KSRRWTFPDGTTCKAKQHNPEDI 815
             |..|..: |.:..:.:.:|.....:||:|||.....|    ||   ...|||:|..     :..
  Fly   819 AMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKS---MVTDGTSCAV-----DSF 875

  Fly   816 TYCISGRCERFSCDNSTSNFFKMDS-SFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKN 879
            ..|::|.|....|||..::..|:|. ..||.|:     |:..:.:...............:|.|.
  Fly   876 DKCVNGICRPAGCDNELNSIAKLDKCGVCEGRN-----DTCHEVTGNLLVSNLLGLNDGNEPNKT 935

  Fly   880 HYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAH 944
            .|                               |...||:     .||.|.:.:....:..::..
  Fly   936 LY-------------------------------YVTRIPK-----GASNIIITQRGYPDQNFIVL 964

  Fly   945 PGCHSNCMTDSKGVQ---------GVTSRLTGVES------------------IQLCSYRIQPCE 982
            .....|.:.:.|.::         |||.:.||..|                  :|:.|..:.|.:
  Fly   965 TDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSK 1029

  Fly   983 RLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDE-PDRSCRVGCQDEFIKYRY---------Y 1037
            |..|..                     ...|.:||: ||....|..      ||:         .
  Fly  1030 RQDTVL---------------------LSYSYTIDKPPDYEAEVEI------YRWEMQAPSNCDS 1067

  Fly  1038 LVNGRNGHFP------PGTRCSPVGKRYCVYGRCLEFGD----DDLPLDKTHISL-------GQL 1085
            |..||:...|      .|.:.:|   ::|......:..|    .|..|:.|..|:       |:|
  Fly  1068 LCEGRSHRLPACISTTQGVKVAP---QFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGEL 1129

  Fly  1086 RTRRKRSSISNDLFNITEIFIKPSHSDISAENIEFTQPIHVSADE 1130
            .||.|..:......|:.    :.:..|:|...::|....|....|
  Fly  1130 GTREKTYACVQTFTNMQ----RSNIVDMSYCKLKFDVAYHEECRE 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	20/96 (21%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	54/223 (24%)
		Reprolysin	332..545	CDD:279729	55/224 (25%)
		TSP1	683..741	CDD:214559	16/63 (25%)
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	20/96 (21%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	53/221 (24%)
		Reprolysin	457..655	CDD:279729	53/219 (24%)
		Salp15	<696..745	CDD:288931	15/90 (17%)
		TSP1	754..806	CDD:214559	17/66 (26%)
		ADAM_spacer1	937..1042	CDD:283607	21/161 (13%)
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910