Protein Alignment stl and Adamts6

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_001102014.2
• Gene: Adamts6 / 361886
• RGDID: 1307678
• Length: 1117
• Species: Rattus norvegicus
• Alignment Length: 1130
• Identity: 262/1130 - (23%)
• Similarity: 399/1130 - (35%)
• Gaps: 334/1130 - (29%)

  Fly   111 PGEAEQHGG-------NPHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEA-----RLQLQQSPQ 163
            |...:|:|.       |....|:|||:..      |.|::...:....:.|     .|.|..:..
  Rat    47 PIRVDQNGAFLSFTVKNDKHSRRRRSMDL------LDPQQAVSKLFFKLSAYGKHFHLNLTLNTN 105

  Fly   164 LIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFY--------RSPAAALDLCEPGNVRGVFQQNG 220
            .:...|......::|.|: :|.     .|:.|.|        .:...||..|.  .:.|:.....
  Rat   106 FVSKHFTVEYWGKDGPQW-KHD-----FLDNCHYTGYLQDQHSTTKVALSNCV--GLHGIIATED 162

  Fly   221 SDLVIHPLP--------ARFGTG-THVLYQARV-------DKSGGGYSEASSRRTASPLDSQLQF 269
            .:..|.||.        ..:..| .||:|:...       |.|..|.|:.:.......|:....|
  Rat   163 EEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSTLQQRHIYDHSHCGVSDLTGSGKPWWLNKTSSF 227

  Fly   270 EPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIE 334
             |.....|:                         .|.||:|||             .:..|.|:|
  Rat   228 -PSLPPIND-------------------------THNHHRQRR-------------SVSTERFVE 253

  Fly   335 TAIFVDSDLYA-HMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDP 398
            |.:..|..:.. |.:|:        :..::|:::|.|..||...:||..:|.::.|| |..:.|.
  Rat   254 TLVVADKMMVGYHGRKD--------IEHYILSVMNIVAKLYRDSSLGNVVNIIVARL-IVLTEDQ 309

  Fly   399 PGLVRSRDVENYLNSFCKWQEK-LNPFSDADPL------HYDHALVLTGLDLVTYDKGKANSQVV 456
            |.|..:...:..|:||||||:. |:..||.:.:      |:|:|:::|..|:.||......:  :
  Rat   310 PNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGT--L 372

  Fly   457 GMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGKVT 521
            |:|:|.|||....||:|||.....|.|.:|||||||.||.||....||....| .:.||.:..:|
  Rat   373 GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGH-EAAKLMAAHIT 436

  Fly   522 -------WSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNF 579
                   ||.|||.|:..||...:..||   |:.....|.......||:.::|::||..::|
  Rat   437 ANTNPFSWSACSRDYITSFLDSGRGTCL---DNEPPKRDFLYPAVAPGQVYDADEQCRFQYG--- 495

  Fly   580 MQASTQSKM-EICRDLHC--RQDGLPWTSHPALEGTECGPNM----WCRGGTCEARSSKQGSYSA 637
             ..|.|.|. |:||:|.|  :.:.....|.||.|||.|....    ||..|.|          ..
  Rat   496 -ATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDC----------VP 549

  Fly   638 LKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSR 702
            ..:||                               ..:.|   .||.||         |:|:..
  Rat   550 FGTWP-------------------------------QSIDG---GWGSWS---------LWGECS 571

  Fly   703 RLLEGSTGLRTLNRSCLN-FPS----RCIGRDRRFVTCNTPQCHKVPVQTINDFATQVC-----M 757
            |...|  |:.:..|.|.: .||    .|:|..:|:.:|||..|   |:.: .||..:.|     |
  Rat   572 RTCGG--GVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPC---PLGS-RDFREKQCADFDSM 630

  Fly   758 QARKSD---PELTGEGQQLPSTLDASCKIFCRTR-TNGTKSRRWTFPDGTTCKAKQHNPEDITYC 818
            ..|...   ...||.|.:       .|.:.|... .|....|.....|||.|     |.:.:..|
  Rat   631 PFRGKHYNWKPYTGGGVK-------PCALNCLAEGYNFYTERAPAVIDGTQC-----NADSLDIC 683

  Fly   819 ISGRCERFSCDNSTSNFFKM--------DSSFCEA---------------RSVRPTRDSSDQESR 860
            |:|.|:...|||...:..:.        |.|.|:|               ..|:..|.|...|.|
  Rat   684 INGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYLEVVQIPRGSVHIEVR 748

  Fly   861 QQTNRQRY-AERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPPPA 924
            :.:..:.| |.:.||   .::|.|. |....:.:...::..|..|||....    ||......|.
  Rat   749 EVSMSKNYIALKSEG---DDYYING-AWTIDWPRKFDVSGTAFHYKRPTDE----PESLEALGPT 805

  Fly   925 SASLIA------------------LDRSSSSESE----WVAHP--GCHSNCMTDSKGVQGVTSRL 965
            |.:||.                  :.|:.|.::|    |...|  .|.:.|....:..:.|..||
  Rat   806 SENLIVMVLLQEQNLGIRYKFNVPIVRTGSGDNEVGFMWTHQPWAECSATCAGGVQKQEVVCKRL 870

  Fly   966 TGVESIQ---------------LCSYRIQPCERLQTAAEYAE--QTC---ARYR-----QKVRGL 1005
            .....:|               .||  .:||.......::.|  :||   .|.|     :||
  Rat   871 DDNSIVQNNFCDPDSKPPENQRACS--TEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKV--- 930

  Fly  1006 SGHGAQISASIDEPD---------RSC-RVGCQDEFI---------------KYRYYLVNGRN-G 1044
               |.....::|..|         .|| ...|..:::               |:|..|....: .
  Rat   931 ---GPSEEETLDYSDCLTHRPVEKESCNNQSCPPQWVALDWSECTPKCGSGFKHRIVLCKSSDLS 992

  Fly  1045 HFPPGTRC----SPVGKRYCVYGRC 1065
            ...|..:|    .|..:..|..|||
  Rat   993 KTFPAAQCPEESKPPARIRCSLGRC 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	76/226 (34%)
		ADAMTS_CR_2	561..625	CDD:465496	24/70 (34%)
		TSP1	683..741	CDD:214559	19/62 (31%)
Adamts6	NP_001102014.2	Pep_M12B_propep	43..191	CDD:460254	30/157 (19%)
		ZnMc_ADAMTS_like	250..465	CDD:239801	77/229 (34%)
		ADAMTS_CR_2	480..548	CDD:465496	25/81 (31%)
		TSP1	561..613	CDD:214559	20/65 (31%)
		ADAMTS_CR_3	618..716	CDD:437068	26/109 (24%)
		ADAMTS_spacer1	719..829	CDD:461796	22/117 (19%)
		TSP1_ADAMTS	844..899	CDD:465950	10/56 (18%)
		TSP1_ADAMTS	903..959	CDD:465950	12/61 (20%)
		TSP1_ADAMTS	963..1017	CDD:465950	8/53 (15%)
		TSP1_ADAMTS	1022..1071	CDD:465950
		PLAC	1083..1115	CDD:462560