DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts18

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_038953789.1	Gene:	Adamts18 / 361412	RGDID:	1560118	Length:	1253	Species:	Rattus norvegicus

Alignment Length:	1076	Identity:	253/1076 - (23%)
Similarity:	389/1076 - (36%)	Gaps:	290/1076 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 GEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRS-------PAAALDL 206
            |:|:  .|:|:.|..|.....:.:...:..::..|  |.:   :::|.|:.       .:.|:..
  Rat   139 GQDL--HLELKPSALLSSHFIVQVLGKDGASETRE--PAV---VQQCLYQGFIRNDSLSSVAVST 196

  Fly   207 CEPGNVRGVFQQNGSDLVIHPLPARF----------GTGTHVLYQARVDKSGGGYSEASSRRTAS 261
            |  ..:.|:.:...::.:|.|||...          |...||||:...:|....|.:..:.:...
  Rat   197 C--AGLSGLIRTRDNEFLISPLPQLLAQQHNYSLPAGHHPHVLYKRTAEKRVRRYQDYPASQRTY 259

  Fly   262 PLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSD 326
            |..|.....|.::......|..|.|.|.....|.::.|:  .|.:....|...| |.|.|.|.|.
  Rat   260 PGHSPSHTPPASQSQETEYRHRRWQKQHFCGRRKKYAPK--PPAEDAYLRFDEY-GGAGRPRRSA 321

  Fly   327 IPEE--LFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKR 389
            ...:  |.:||.:..|:       |....:.:..|.:::|.::|.|..|:...|:|..||.|:..
  Rat   322 RKSQKGLNVETLVVADA-------KMVEKHGKDDVTTYILTVMNMVSSLFKDGTIGSDINIVVVS 379

  Fly   390 LEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQ 454
            |.:.:. :|.||:.:...:..|||||:||..|   ...:...:|||::|||.|:.::.....::
  Rat   380 LILLED-EPGGLLINHHADQSLNSFCQWQSAL---VGKNGKRHDHAILLTGFDICSWKNEPCDT- 439

  Fly   455 VVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTM-HIMSPKL--G 516
             :|.|.:.|||:...||||||.......|.:|||.|||.||.||.:...|.... :||||.|  .
  Rat   440 -LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNPCRKAEGNIMSPTLTGN 503

  Fly   517 SGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQ 581
            :|..:||.|||.||:.||..|||.||.|.....|.:.:.  .:|||:.::|:.||..:||.....
  Rat   504 NGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKYP--DKLPGQIYDADTQCKWQFGAKAKL 566

  Fly   582 ASTQSKMEICRDLHCRQDGLPWTSH-------PALEGTECGPNMWCRGGTCEARSSKQGSYSALK 639
            .|.....:||:.|.|.:.|     |       ||.|||.||.:||||.|.|
  Rat   567 CSLGVMKDICKSLWCHRVG-----HRCETKFMPAAEGTVCGLSMWCRQGQC-------------- 612

  Fly   640 SWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRL 704
                           :|         |.|..|  ..:.|..|.|.:|||   |...|
  Rat   613 ---------------VR---------LGDLGP--RPIHGQWSAWSKWSE---CSRTC-------- 640

  Fly   705 LEGSTGLRTLNRSCLNFPSR-----CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSD- 763
               ..|::...|.|.|...:     |.|..|.:..||...||:..:    ||..|.|.:.....
  Rat   641 ---GGGVKYQERHCSNPKPQYGGKYCPGSSRIYKLCNINPCHENSL----DFRAQQCAEYNNKPF 698

  Fly   764 --------PELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTF--------PDGTTCKAKQHNP 812
                    |....|.:.       .||::|       |:..:.|        .|||.|     :|
  Rat   699 RGWLYRWRPYTKVEEED-------RCKLYC-------KAENFEFFFAMSGKVKDGTPC-----SP 744

  Fly   813 EDITYCISGRCERFSC------------------DNSTSNFFKMDSSFCEARSVRPTRDSSDQES 859
            .....||.|.||...|                  ||||..|:|                 ....|
  Rat   745 HRNDVCIDGICEPVGCDHELGSKAVSDACGVCKGDNSTCKFYK-----------------GLYLS 792

  Fly   860 RQQTNR----------QRYAERQEGKPQKNHYENEVAKRPSYGQGN-HINAP------ASPYKRR 907
            :.:.|.          .|..|.||.:...::.......:..|..|. :|:.|      .:.::
  Rat   793 QHKANEYYPVVTIPAGARSIEIQELELSSSYLAVRSLSQKYYLTGGWNIDWPGDFTFAGTTFE-- 855

  Fly   908 NYHKPY-PPEIPRPPPPASASLI--ALDRSSSSESEW---------VAHPGC----------HSN 950
             |.:|: .||....|.|.:.:|:  .|.:..:....|         |..|..          .|:
  Rat   856 -YQRPFNRPERLYAPGPTNETLVFEILTQGKNPGITWKYALPKVMNVTQPAAKRHHHTWRTVQSD 919

  Fly   951 CMTDSKG----VQGVTSR--LTGVESIQLCSYRIQP------CERLQTAAEY-------AEQTCA 996
            |.....|    ::.:..|  .|.|.| ..||.|.:|      |......|.:       ..::||
  Rat   920 CSVTCGGGYISIKAICLRDQNTQVNS-SFCSVRTKPATEPKLCNAFSCPAYWLPGEWSTCSKSCA 983

  Fly   997 RYRQ--KVRGLSGHGAQISASI--------------------------DEPDRSCRVGCQDEFIK 1033
            ..:|  |:|.:.....|...::                          ..|...|...| ...::
  Rat   984 GGQQSRKIRCVQKKPFQKEEAVLHSLCPVSTPTQVQVCNSHACPPEWSPGPWSQCSKTC-GRGVR 1047

  Fly  1034 YRYYLVNGRNGHFPPGTRCS----PVGKRYCVYGRC 1065
            .|..|.........|.:.||    |..:..||.|||
  Rat  1048 RREVLCTSPAAETLPESLCSSSPKPEAQEGCVLGRC 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	17/100 (17%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	76/214 (36%)
		Reprolysin	332..545	CDD:279729	76/215 (35%)
		TSP1	683..741	CDD:214559	15/62 (24%)
Adamts18	XP_038953789.1	Pep_M12B_propep	99..238	CDD:396235	20/107 (19%)
		ZnMc_ADAMTS_like	328..529	CDD:239801	75/213 (35%)
		ADAM_CR_2	546..613	CDD:407643	27/100 (27%)
		TSP1	627..679	CDD:214559	16/65 (25%)
		ADAM_spacer1	784..896	CDD:368694	21/131 (16%)
		TSP1_ADAMTS	918..966	CDD:408800	12/48 (25%)
		TSP1_ADAMTS	970..1026	CDD:408800	6/55 (11%)
		TSP1_ADAMTS	1030..1083	CDD:408800	12/53 (23%)
		TSP1_ADAMTS	1091..1150	CDD:408800
		TSP1_ADAMTS	1159..1205	CDD:408800
		PLAC	1220..1250	CDD:400844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910