Protein Alignment stl and Adamts19

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_001101903.2
• Gene: Adamts19 / 361332
• RGDID: 1308359
• Length: 1211
• Species: Rattus norvegicus
• Alignment Length: 1189
• Identity: 265/1189 - (22%)
• Similarity: 405/1189 - (34%)
• Gaps: 401/1189 - (33%)

  Fly    17 IVLTTLWLLIGASSSSSSTSSTNP---KSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALIF 78
            :|...||.....:::..||.|.:|   :|.....|.:.|              |..||....
  Rat    42 VVFPALWRRESLNATGLSTGSADPGSGRSAGGGSRGQPS--------------GSSREVRSV--- 89

  Fly    79 GSRSP-EEA------PEFKLVHLAQQRPEEQQRLEERKRP----GEAEQHGGNPHQRRQRRSLPS 132
             :|:| |||      |.|....| |...|:::.||.::.|    |:.....|.|   ...:..||
  Rat    90 -ARAPLEEAAGGQSEPWFAARPL-QPGAEDEEELESQELPRGSSGDTSLPSGAP---APWQPSPS 149

  Fly   133 EDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTEN--GTQF-VEHSPQLLKRLER 194
            .......||.::|:.:.|:|..|:     |.|..|.::.:||...  ..:| ||..|
  Rat   150 PQPPSSPPPAQQEEPSTEEVLLRI-----PALSRDLYLLLRRDGRFLAQRFAVEQWP-------- 201

  Fly   195 CFYRSPAAALDLCEPGNVRGVFQQNGSDLVIHPLP------ARFGTGT---HVLYQARVDKSGGG 250
                         :||       .:.:...:.|.|      :.|.|||   |....|.....|||
  Rat   202 -------------KPG-------PDPTRATVDPRPPMPSDASCFYTGTVLRHPGSLASFSTCGGG 246

  Fly   251 YSEASSRRTASPLDSQLQFEPD---AEEFNEPRRRLRAQSQLQSPLRLRFQPRHHH--------P 304
                        |...:|...|   .|.||:      ..:.:..|.||..|.|...        .
  Rat   247 ------------LMGFIQLNEDFIFIEPFND------TMAIIGHPHRLYRQKRSSEERVTEKSAA 293

  Fly   305 HQHH--------QQRRRRYIGDAPRSRWS-DIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVV 360
            |:||        :.|.::...:....|:| .:|::..|||.:..|..:.::       :......
  Rat   294 HRHHCGVISDKGRPRSKKLAENRREKRYSYKLPQDYNIETVVVADPAMVSY-------HGADAAR 351

  Fly   361 SFLLAMINGVQLLYHHPTLGRRINF-VLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPF 424
            .|:|.::|.|..|:.|.:||.::|. |:|.:.:.::  |..|......|..|.||||||.:  .|
  Rat   352 RFILTILNMVFNLFQHKSLGVQVNLRVIKLILLHET--PADLYIGHHGEKMLESFCKWQHE--EF 412

  Fly   425 SDADPLH-------------YDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEA 476
            ...:.:|             .|.|:::|..|...:.....::  ||:|.:.|||:....|.|.|.
  Rat   413 GRKNDIHLEMSTSWGEDVASVDAAILITRKDFCVHKDEPCDT--VGIAYLNGMCSEKRKCIIAED 475

  Fly   477 KHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPK----LGSGKVTWSKCSRTYLEDFLMDP 537
            ......|.:|||:|||:|:.||....||...:||||.:    ...|.|:||:||:..||.||...
  Rat   476 NGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSK 540

  Fly   538 QAECLFDRD-----SFAGPWDHTAGGRLPGERFNANQQCMLRFG--KNFMQASTQSKMEICRDLH 595
            .:.||...|     |...|      .:|||..:.|::||.:.||  .:|.|   :.:..||..|.
  Rat   541 ASSCLLHTDPQSLSSVLVP------SKLPGMAYTADEQCQILFGPLASFCQ---EMQHVICTGLW 596

  Fly   596 CRQDG---LPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRH 657
            ||.:|   ......|.::||:|.|..||:.|.|..|:.           .|||:.
  Rat   597 CRVEGDTECRTKLDPPMDGTDCDPGKWCKAGECTRRTP-----------APEHLA---------- 640

  Fly   658 EPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFP 722
                                      ||||..|:|...|           .:|:.:..|.|....
  Rat   641 --------------------------GEWSTWSSCSRSC-----------GSGVSSRERKCPGLG 668

  Fly   723 SR---CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDAS--CK 782
            |.   |.|..:::..|..|.| ...:....|:..| ....|.|.|:   ...|..:..|..  |.
  Rat   669 SEARDCNGPRKQYRICENPPC-PAGLPGFRDWQCQ-AYSVRTSYPK---HALQWQAVFDEEKPCA 728

  Fly   783 IFCRTRTNGTKSRRWTFP--------------DGTTCKAKQHNPEDITYCISGRCERFSCDNSTS 833
            :||.             |              |||:|     ..:.:..|.:|||::..||....
  Rat   729 LFCS-------------PVGKEQPVLLSEKVLDGTSC-----GYQGLDVCANGRCQKAGCDGLLG 775

  Fly   834 NFFKMD------------------------SSFCE------------------ARSVRPTRDSSD 856
            :..:.|                        :.:.|                  |.|....||:
  Rat   776 SLAREDHCGVCNGNGKSCKVIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDA-- 838

  Fly   857 QESRQQTNRQRYAERQEGKPQKN---HY------ENEVAKRPSYGQGNHINAPASP-------YK 905
              |:|..|.....|.........   ||      |...||.|:          .:|       ::
  Rat   839 --SKQSINSDWKIEHSGAFSLAGTTVHYIRRGLWEKISAKGPT----------TTPLHLLVLLFQ 891

  Fly   906 RRNYHKPYPPEIPRPPPPASASLIALDRSSSSES----EWVAHPG---CHSNC------------ 951
            .:||...|...:|..|.|        |..||.||    .| .|.|   |::.|
  Rat   892 DQNYGLHYEYTVPSDPLP--------DNQSSKESGPLFMW-THAGWGDCNATCGGGERKTTVSCT 947

  Fly   952 --------MTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGH 1008
                    :.|:|..:.:|.   ....|:.|:.  |||:......|:.  ||:|       ..|.
  Rat   948 KIMNKNISLVDNKKCKDLTK---PEPQIRKCNE--QPCQTRWMMTEWT--TCSR-------TCGK 998

  Fly  1009 GAQISASIDEPDRSCRVGC 1027
            |.|          |.:|.|
  Rat   999 GVQ----------SRQVAC 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	67/229 (29%)
		ADAMTS_CR_2	561..625	CDD:465496	23/68 (34%)
		TSP1	683..741	CDD:214559	15/60 (25%)
Adamts19	NP_001101903.2	Pep_M12B_propep	162..277	CDD:460254	34/165 (21%)
		ZnMc_ADAMTS_like	329..546	CDD:239801	67/229 (29%)
		ADAMTS_CR_2	563..630	CDD:465496	23/69 (33%)
		ADAMTS_CR_3	<727..793	CDD:437068	15/83 (18%)
		ADAMTS_spacer1	795..904	CDD:461796	19/122 (16%)
		TSP1_ADAMTS	928..980	CDD:465950	8/56 (14%)
		TSP1_ADAMTS	984..1040	CDD:465950	10/43 (23%)
		TSP1_ADAMTS	1044..1086	CDD:465950
		TSP1_ADAMTS	1095..1147	CDD:465950