DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts3

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_808540.2	Gene:	Adamts3 / 330119	MGIID:	3045353	Length:	1204	Species:	Mus musculus

Alignment Length:	1349	Identity:	292/1349 - (21%)
Similarity:	438/1349 - (32%)	Gaps:	457/1349 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IVLTTLWL----LIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALI 77
            :|..:|||    |:...:|:...:.|: :.|.|:|..||...|..:......|.||...|..:..
Mouse     1 MVFLSLWLIAASLVEVRTSADGQAGTD-EMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSAN 64

  Fly    78 FGSRSPEEA---PEFKLVHLAQQRPEEQQRLEERKR---PGEAEQHGGNPHQRRQRRSLPSEDGN 136
            ...|||.:.   .|....::.....:...||:....   ||...:.    |:...|....::..|
Mouse    65 HKKRSPRDVSSNSEHLFFNVTAFGRDFHLRLKPNTHFIAPGAVVEW----HETAPRPGNTTDPRN 125

  Fly   137 GPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPA 201
            ..|     ...|.|.......||.|...:.|....     .||                     :
Mouse   126 SHL-----HGSASEGSWRSEPLQTSCAYVGDIMDI-----PGT---------------------S 159

  Fly   202 AALDLCEPGNVRGVFQQNGSDLVIHPLP---------ARFGTGTHVLY-QARVDKSGGGYSEASS 256
            .|:..|:  .:.|:.:.:..:..|.||.         .|.    ||:| ::.|::.....||...
Mouse   160 VAISNCD--GLAGMIKSDDEEYFIEPLERGKQMDEENGRI----HVVYKRSAVEQPPRDVSEDVY 218

  Fly   257 RRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPR 321
            .|           |.|.|..::..   ...|.:...|             :...||||:.|:
Mouse   219 HR-----------ESDLEGLDDLG---TVYSNIGQQL-------------NKTMRRRRHTGE--- 253

  Fly   322 SRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFV 386
                   .:..||..:.||..:.....|       ..|.::||.::|.|..:||..:||..||.|
Mouse   254 -------NDYNIEVLLGVDDSVVRFHGK-------EHVQNYLLTLMNIVNEIYHDESLGVHINVV 304

  Fly   387 LKRLEIWKSWDPPGLVRSRDVENYLNSFCKW---QEKLNPFSDADPLHYDHALVLTGLDLVTYDK 448
            |.|:.:........|:...:....|.:.|:|   |:|.:| :.|:  |:|||:.||..|.
Mouse   305 LVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKTDP-NHAE--HHDHAIFLTRQDF----- 361

  Fly   449 GKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISC-DPTM--HI 510
            |.|..|  |.|.|.|||..:.|||:|....|.|.||||||.||.|||.||.:...| |.|.  .:
Mouse   362 GPAGMQ--GYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSV 424

  Fly   511 MSPKLGSG--KVTWSKCS----RTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQ 569
            |:|.:.:.  :..||:||    :.|:..:      :||.| |.|...|....  .|||..::.::
Mouse   425 MAPLVQAAFHRYHWSRCSGQELKRYIHSY------DCLLD-DPFEHDWPKLP--ELPGINYSMDE 480

  Fly   570 QCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPW----TSHPALEGTECGPNMWCRGGTCEARSS 630
            ||...||..:...:.....:.|:.|.|.....|:    ...|.|:||||....||..|.|..:::
Mouse   481 QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNA 545

  Fly   631 KQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESG 695
            .|..                                            ...|||.|::..:|...
Mouse   546 NQQK--------------------------------------------QDGNWGSWTKFGSCSRT 566

  Fly   696 CLYGQSRRLLEGSTGLRTLNRSC-----LNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQV 755
            |           .||:|...|.|     :|....|.|.:..:..|||.:|.|    ...||..|.
Mouse   567 C-----------GTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQK----HFEDFRAQQ 616

  Fly   756 CMQARKSDPELTGEGQQLPSTLDAS---CKIFCRTRTNGTKS-RRWTFPDGTTCKAKQHNPEDIT 816
            |.|..........:...||.....|   |.::|:::..|..: .:....|||.|..|  :|..|
Mouse   617 CQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYK--DPYSI- 678

  Fly   817 YCISGRCERFSCDNST-SNFFKM---------DSSFCEARSVRPT-------------------- 851
             |:.|.|.:..||... ||  |:         |:|.|  |:|:.|
Mouse   679 -CVRGECVKVGCDREIGSN--KVEDKCGVCGGDNSHC--RTVKGTFTRTPRKLGKTRGAFVLPKG 738

  Fly   852 -RDSSDQESRQQTNRQRYAERQEGKPQKNHY----ENEVAKRPSY---G-----------QGNHI 897
             |:.|..|:|:..|......:..|     ||    :.|.||..::   |           :..|.
Mouse   739 ARNISLAETRETKNVLAIKNQATG-----HYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHT 798

  Fly   898 NAPASPYKRRNYHKPYPPEIPRPPPPASASLIAL------DRSSSSESEWVAH----PGCHSN-- 950
            :.|        .|.|               :|.|      |..||...:::.|    |..:||
Mouse   799 DGP--------LHDP---------------VIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNV 840

  Fly   951 --------------------------------C--MTDSK--------------------GVQGV 961
                                            |  .:|||                    .:|..
Mouse   841 IQEELDTFEWALKSWSQCSEPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQEC 905

  Fly   962 T------------SRLTGVESIQLCSYRI-------------------------QPCERLQTAAE 989
            |            ||..|....||.:.|.                         :||.|:...|:
Mouse   906 THPVWAADEWEHCSRSCGSSGNQLRTVRCLQPLQDGTNRSVHSKYCLGDRPESRRPCNRVPCPAQ 970

  Fly   990 Y-------AEQTC---ARYRQKVRGLSGH----------GAQISASIDEP---DRSCRVGCQDEF 1031
            :       ...||   ...||.:.....|          ..|:....|||   |:|  :.||.|.
Mouse   971 WKTGSWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRPCQLPPCNDEPCLGDKS--IFCQMEV 1033

  Fly  1032 IKYRYYLVNG-----------RNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLP---LDKTHISL 1082
            :. ||..:.|           |:|..||     |..:..........||..|||   :..|....
Mouse  1034 LA-RYCSIPGYNKLCCESCSKRSGTLPP-----PYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLP 1092

  Fly  1083 GQLRTRRKRSSISNDLFNITEIFIKPSHSDISAENIE--FTQPIHVSAD 1129
            ....||.::.|:|             |.|.::..|.:  |......|||
Mouse  1093 SSSGTRAEKKSLS-------------SFSSMANPNADAAFRASSRASAD 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	14/92 (15%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	73/223 (33%)
		Reprolysin	332..545	CDD:279729	74/224 (33%)
		TSP1	683..741	CDD:214559	16/62 (26%)
Adamts3	NP_808540.2	Pep_M12B_propep	66..200	CDD:279848	28/174 (16%)
		ZnMc_ADAMTS_like	256..457	CDD:239801	73/223 (33%)
		Reprolysin	258..460	CDD:279729	75/225 (33%)
		TSP1	554..605	CDD:214559	16/61 (26%)
		ADAM_spacer1	713..828	CDD:283607	24/142 (17%)
		TSP1	914..968	CDD:214559	9/53 (17%)
		TSP1	971..1016	CDD:214559	6/44 (14%)
		PLAC	1024..1052	CDD:285849	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810