DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts20

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_038936261.1	Gene:	Adamts20 / 315263	RGDID:	1307725	Length:	1928	Species:	Rattus norvegicus

Alignment Length:	1117	Identity:	262/1117 - (23%)
Similarity:	395/1117 - (35%)	Gaps:	328/1117 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 NPHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTE-------- 176
            |.|..|::||     ...|.||.......   :.|..||.|.....|.||:....||
  Rat    58 NRHFSRKKRS-----SGVPEPPPLRTHYR---ISAYGQLFQLNLSADSAFLAAGYTEVHLGTPVP 114

  Fly   177 -NGTQFVEHSPQLLKRLERCFYRSPA-------AALDLCEPGNVRGVFQQNGSDLVIHPLPARFG 233
             .|.:..| .|.    |..||||...       |...||  |.:.|.|:.|..:..:.|:....|
  Rat   115 GPGGRSAE-PPD----LRHCFYRGQVNAREDHIAVFSLC--GGLMGTFKANDGEYFLEPVLKADG 172

  Fly   234 T-------GTHVLYQARV-------DKSGG--GYSEASSRRTASPLDSQLQFEPDAEEFNEPRRR 282
            :       ..|::|:..|       .:|.|  |.||..:.:||.|..|   |.....:.|   ||
  Rat   173 SEHEDDHNKPHLIYRQEVKRNAFVRSQSHGPCGVSENQTEKTALPSPS---FRNTTGDLN---RR 231

  Fly   283 LRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHM 347
            ..|...|:..     :.|.|       .|.:|:: ..||          ::|..:..|:.:..|.
  Rat   232 KGAVFGLEGE-----RSRLH-------SRSKRFL-SYPR----------YVEVMVTADAKMVRHH 273

  Fly   348 QKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLN 412
            .:|        :..::|.:::.|..:|...::|..||.|:.:|.|..| :..|.|.|.:....|.
  Rat   274 GQN--------LQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVIIHS-EQEGPVISFNAATTLR 329

  Fly   413 SFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAK 477
            :||.||:..|...||.|.|:|.|:::|..|:.   ..|.....:|:|.:..:|....||:|:|..
  Rat   330 NFCLWQQSQNVLDDAHPSHHDTAVLITREDIC---GAKEKCDTLGLAELGTLCDPSRSCSISEEN 391

  Fly   478 HFESVFVVAHEIGHNLGMRHD----AKEISCDPTMHIMSPKLG--SGKVTWSKCSRTYLEDFLMD 536
            ...:.|.:|||:||...:.||    .||.......|:|:|.|.  :...|||.||:.::.:||..
  Rat   392 GLSAAFTIAHELGHVFNVPHDDSFKCKESGTKHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDT 456

  Fly   537 PQAECLFDRDSFAGPWDHTAGGR-------LPGERFNANQQCMLRFGKNFMQASTQSKMEICRDL 594
            ...|||.|:.:          ||       |||..::.|:||.|.||..   :.....::.||.|
  Rat   457 GHGECLLDKPN----------GRTYDLSPQLPGSVYDGNKQCELMFGPG---SQVCPYLKQCRRL 508

  Fly   595 HCRQ-DGLP---WTSH-PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKI 654
            .|.. :|:.   .|.| |..:||.|||.|.|..|.|..|..
  Rat   509 WCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDM------------------------ 549

  Fly   655 IRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSC- 718
                         :..|:|.|       ||.|...|:|...|           ..|:|:..|.|
  Rat   550 -------------ETRPVDGE-------WGPWGPYSSCSRTC-----------GGGIRSTARLCD 583

  Fly   719 ----LNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTG---EGQQLPS- 775
                .|....|:||..:|.:|||..|.|..    .||..:.|........:::|   ..:.||.
  Rat   584 RPEPRNGGRYCVGRRMKFRSCNTDSCPKGK----RDFREKQCSDFDGKHFDISGLPPNVRWLPKY 644

  Fly   776 ---TLDASCKIFCRTRTNGTKS---RRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCDNSTSN 834
               .:...||::||..  ||.|   .:....|||.|..:.:   ||  |:.|.|.:..||:..::
  Rat   645 SGIAVKDRCKLYCRVA--GTTSFYQLKDRVADGTPCGTETN---DI--CVQGLCRQAGCDHVLNS 702

  Fly   835 FFKMDS-SFCEARSVRPTRDSSDQESRQ----------------------QTNRQRYAERQEGKP 876
            ..|.|. ..|          ..|..|.|                      .||.:.......|:|
  Rat   703 KAKRDKCGVC----------GGDNSSCQTLAGVFNSAHYGYNVVVKIPAGATNIEILQHSYSGRP 757

  Fly   877 QKNHYENEVAKRPSYG----QGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSS 937
            :.::|   :|...:.|    .||.:.:.|.  |..|        |.......|.|..:::|.:|:
  Rat   758 EDDNY---LALSDTQGNFLLNGNFVVSMAK--KEIN--------IQGAVFEYSGSNNSIERINST 809

  Fly   938 ---ESEWVAHPGCHSNCMTD----------------------------SKGVQGVTSRL------ 965
               |:|.|....|..|....                            :|..||:..|.
  Rat   810 DRLEAELVLQVLCVGNLYNPDVHYIFNIPIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACIRK 874

  Fly   966 --TGVESIQLCSYRIQP---CERLQTAAEY-----AEQTC-ARYRQKVRGLSGHGAQISA----S 1015
              ..|.|.|.||:...|   .||..|..|.     .:..| ::..|..|.|..|..:.|.    :
  Rat   875 SDRAVVSDQSCSHLPLPLFVTERCNTDCELRWHITGKSDCSSQCGQGYRTLDVHCMKYSVHKGQT 939

  Fly  1016 IDEPDRSC--------RVGCQDEFIKYRYYLVNGRNGHFPPGTRCS-------PVGKRYCVYG-- 1063
            :...|:.|        |..|....:..|:        |:...::||       ...:.|||.|
  Rat   940 VPVGDQYCGDQLKPPNREPCHGSCVLTRW--------HYSEWSQCSRSCGGGEKTRESYCVNGFG 996

  Fly  1064 -RCLEFGDDDLP 1074
             |..|....:||
  Rat   997 HRLAERECQELP 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	26/106 (25%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	62/217 (29%)
		Reprolysin	332..545	CDD:279729	63/218 (29%)
		TSP1	683..741	CDD:214559	18/62 (29%)
Adamts20	XP_038936261.1	Pep_M12B_propep	41..186	CDD:396235	35/142 (25%)
		ZnMc_ADAMTS_like	257..463	CDD:239801	63/227 (28%)
		ADAM_CR_2	478..545	CDD:407643	24/69 (35%)
		TSP1	558..610	CDD:214559	18/62 (29%)
		ADAM_spacer1	720..838	CDD:368694	23/130 (18%)
		TSP1_ADAMTS	906..959	CDD:408800	9/52 (17%)
		TSP1_ADAMTS	968..1020	CDD:408800	11/49 (22%)
		TSP1_ADAMTS	1023..1075	CDD:408800
		TSP1_ADAMTS	1078..1132	CDD:408800
		TSP1_ADAMTS	1154..1206	CDD:408800
		TSP1_ADAMTS	1209..1261	CDD:408800
		TSP1_ADAMTS	1306..1357	CDD:408800
		TSP1_ADAMTS	1360..1412	CDD:408800
		TSP1_ADAMTS	1418..1471	CDD:408800
		TSP1_ADAMTS	1474..1527	CDD:408800
		TSP1_ADAMTS	1532..1585	CDD:408800
		TSP1_ADAMTS	1657..1708	CDD:408800
		GON	1713..1880	CDD:400843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910