DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts9

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001101347.1	Gene:	Adamts9 / 312566	RGDID:	1306889	Length:	1880	Species:	Rattus norvegicus

Alignment Length:	1189	Identity:	253/1189 - (21%)
Similarity:	393/1189 - (33%)	Gaps:	379/1189 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 RSPEEAPEFKLVHLAQQRPEEQQRLEE-------RKRPGEAEQHGGNPHQRRQRRSLPSEDGNGP 138
            |||:.|...:...|..::.:..:.|.|       |..| ..|....|.|.:|:|||:.|  .:.|
  Rat    21 RSPDSAAAVRKDRLHPRQVKLLESLSEYEIASPIRVNP-LGEPFPTNVHFKRRRRSINS--ASDP 82

  Fly   139 LPP-EEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENG----------------TQFVEHSP 186
            .|. ......:....:...:|:...|    .|:|......|                .|...:|.
  Rat    83 WPAFASSSSSSSTSSQEHYRLKAFGQ----QFLFNLTAHTGFIAPLFTVTLLGEPGVNQSKLYSE 143

  Fly   187 QLLKRLERCFYR-------SPAAALDLCEPGNVRGVFQQNGSDLVIHPL--------------PA 230
            :.:: |..|||:       ...|.:.||  ..:.|.|:.:..|..|.||              |
  Rat   144 EEME-LRHCFYKGHVNTKSEHTAVISLC--SGMMGTFRSHDGDYFIEPLLSVDEQEDEEEQNKP- 204

  Fly   231 RFGTGTHVLYQ----ARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQS 291
                  ||:|:    .|...:|....:.|..:.:...|.:.         ...|:|.:..|....
  Rat   205 ------HVIYRRNNPQREPSTGKHACDTSELKNSYSKDKRK---------TRLRKRRKRNSLADD 254

  Fly   292 PLRLR----------FQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAH 346
            ...|:          :..|.:........:|.:.....||          |:|..:..|..:..:
  Rat   255 VAALKRGMATKAFSGYNNRTNGTRDRRNHKRTKRFLSYPR----------FVEVMVVADHRMVLY 309

  Fly   347 MQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRL-EIWKSWDPPGLVRSRDVENY 410
            ...|        :..::|.:::.|..:|...::|..||.|:..| .|....:.|.:  :.:.:..
  Rat   310 HGSN--------LQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPSI--NFNAQTT 364

  Fly   411 LNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINE 475
            |.:||:||...|....   :.:|.|:::|..|:.   :.:.....:|:|.:..:|....||:|:|
  Rat   365 LKNFCQWQHSKNHLGG---IQHDTAVLVTREDIC---RAQDKCDTLGLAELGTICDPYRSCSISE 423

  Fly   476 AKHFESVFVVAHEIGHNLGMRHD----AKEISCDPTMHIMSPKLG--SGKVTWSKCSRTYLEDFL 534
            .....:.|.:|||:||...|.||    .||.......|:|:|.|.  :....||||||.|:.:||
  Rat   424 DSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFL 488

  Fly   535 MDPQAECLFDRDSFAGPWDHT--AGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCR 597
            .....|||.:.     |...|  ...:|||..:|.|:||.|.||
  Rat   489 DTGYGECLLNE-----PQSRTYPLPSQLPGLLYNVNKQCELIFG--------------------- 527

  Fly   598 QDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRI 662
                        .|::..|.|.|:.|.|.
  Rat   528 ------------PGSQVCPYMHCKFGFCV------------------------------------ 544

  Fly   663 PPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPS---- 723
                    |.:.|.|....:||.||...||...|           ..|:||..|.| |.|.
  Rat   545 --------PKEMEGPAIDGSWGSWSHFGACSRTC-----------GGGIRTAIREC-NRPEPKNG 589

  Fly   724 --RCIGRDRRFVTCNTPQC--HKVPVQTINDFATQVCMQARKSDPELTGEGQQLPST-------- 776
              .|:||..:|.:|||..|  ||      .||..:.|.........:.|   .|||.
  Rat   590 GRYCVGRRMKFKSCNTEPCPKHK------RDFREEQCAYFDGKHFNING---LLPSVRWVPKYSG 645

  Fly   777 --LDASCKIFCRTRTNGTKSR-RWTFPDGTTCKAKQHNPEDITYCISGRCERFSCD---NSTSNF 835
              :...||:|||...|....: |....|||.|   ..:..||  |:.|.|.:..||   ||.:..
  Rat   646 ILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPC---GQDTNDI--CVQGLCRQAGCDHILNSKARK 705

  Fly   836 FKM-----DSSFCEARS-------------VRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYE 882
            .|.     |:|.|:..:             ||....::..:.||.:        ..||.:.::|
  Rat   706 DKCGICGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATSLDVRQHS--------FSGKSEDDNY- 761

  Fly   883 NEVAKRPSYGQ----GNHINAPASPYKRR-----------------------------------N 908
              :|...|.|:    |:.:   .|..||.                                   :
  Rat   762 --LALSNSRGEFLLNGDFV---VSMSKREVRVGSAMIEYSGSDNVVERLNCSDRIEEELLLQVLS 821

  Fly   909 YHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSR--LTGVESI 971
            ..|.|.|::     ..|.::...||  |.:..|.:| |....|   ||..||...|  :...||.
  Rat   822 VGKLYNPDV-----RYSFNIPIEDR--SQQFYWNSH-GPWQAC---SKPCQGERRRKLVCTRESD 875

  Fly   972 QLCSYRIQPCERLQTAAEYAEQ--TCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKY 1034
            || :...|.|:||.......|.  |....|..:...|...||........|..|.
  Rat   876 QL-TVSDQRCDRLPQPGPVTEACGTDCDLRWHIASKSECSAQCGLGYRTLDIHCA---------- 929

  Fly  1035 RYYLVNGRN--------GHFP-PGTR------CSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQ 1084
            :|..|:|:.        |..| |..:      ||..|.||..:..|.:..|..
  Rat   930 KYSRVDGKTEKVDDSFCGSQPRPSNQEKCSGECSTGGWRYSAWTECSKSCDGG------------ 982

  Fly  1085 LRTRRKRS---SISNDLFN 1100
              |:|:|:   :..||:.:
  Rat   983 --TQRRRAICVNTRNDVLD 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	22/120 (18%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	57/218 (26%)
		Reprolysin	332..545	CDD:279729	58/219 (26%)
		TSP1	683..741	CDD:214559	22/65 (34%)
Adamts9	NP_001101347.1	Pep_M12B_propep	72..207	CDD:279848	28/150 (19%)
		Reprolysin	294..500	CDD:279729	59/236 (25%)
		ZnMc_ADAMTS_like	294..497	CDD:239801	58/228 (25%)
		TSP1	557..609	CDD:214559	21/63 (33%)
		ADAM_spacer1	719..837	CDD:283607	18/136 (13%)
		TSP1	967..1020	CDD:214559	9/47 (19%)
		TSP1	1021..1074	CDD:214559
		TSP1	1080..1132	CDD:214559
		TSP1	1152..1205	CDD:214559
		TSP1	1205..1262	CDD:214559
		TSP1	1294..1346	CDD:214559
		TSP1	1348..1402	CDD:214559
		TSP1	1407..>1430	CDD:214559
		TSP1	1466..1517	CDD:214559
		TSP1	1526..1575	CDD:214559
		TSP1	1577..>1602	CDD:214559
		GON	1700..1868	CDD:285848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810