Protein Alignment stl and Adamtsl4

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_038958286.1
• Gene: Adamtsl4 / 310670
• RGDID: 1561012
• Length: 1035
• Species: Rattus norvegicus
• Alignment Length: 1224
• Identity: 237/1224 - (19%)
• Similarity: 341/1224 - (27%)
• Gaps: 470/1224 - (38%)

  Fly    84 EEAPEFKLVHLAQQRPEEQQRLEER-----KRPGEAEQHGGNPHQRRQRR-------SLPSEDGN 136
            :|....:|:..:.|.|.|:.::.|.     .|.....|..|...|||.|.       |||
  Rat    25 QEVSPGQLLGPSLQTPSEEDQVPEGLWGPWGRWASCSQPCGVGVQRRSRTCELHPALSLP----- 84

  Fly   137 GPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPA 201
             |.||...|........:|.|..:.||.:                  :.||  .|......|.||
  Rat    85 -PRPPRHPEAPQPRGQGSRPQTPRDPQSL------------------YRPQ--PRGRGGPLRGPA 128

  Fly   202 AALDLCEPGNVRGVFQQNGSDLVIHPL-PARFGTG----THVLYQAR--VDKSGGGYSEASSRRT 259
            :.:...|....||..:....|    |: |..||.|    ...|:::|  ..|.|.....:::..|
  Rat   129 SQVGREETQEPRGAQRFRVRD----PIKPGMFGYGRVPFALPLHRSRRLAHKPGQPKDSSTAEET 189

  Fly   260 ASPLDSQLQFEPDAEEFNEPRRR---LRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPR 321
               |.||......|.|.:.|..:   |||||:         .|....|.....|.      :.|
  Rat   190 ---LPSQPPSTEPASEKHSPHMQPPELRAQSR---------SPSAETPRSGTAQT------EVP- 235

  Fly   322 SRWSDIPEELFI--ETAIFVDS-DLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRI 383
            ||.|..|.::.|  .|:.|.|| ......:...||:..::......:.:...||...|
  Rat   236 SRTSSAPSDMGIPAPTSSFRDSRSFQGSPEPRMPTSQGAERQPHPFSPVTRSQLSRRH------- 293

  Fly   384 NFVLKRLEIWKSWDPPG---------LVRSRDVENYLNSF--------CKWQ-EKLN-------P 423
                        |.|||         |..:||...:.:.|        |..: |::.       |
  Rat   294 ------------WRPPGSPHRSPDGWLPLTRDSSPHWSLFAPSSPTPECSGESEQMRACSQEPCP 346

  Fly   424 FSDADPLHYDHALVLTGLDLVTYDKGKANSQVV---GMATVKGMCTSIYSCTINEAKHFESVFVV 485
            ....||         ..|....:|..:...|:.   ....|:|.    ..|.:|
  Rat   347 PEQPDP---------RALQCAAFDSQEFMGQLYQWEPFTEVQGS----QRCELN----------- 387

  Fly   486 AHEIGHNLGMRHDAK---EISCDP-------TMHIMSPK----LGSG------------------ 518
            ....|....:||..|   ...|.|       ..|.:||.    ||||
  Rat   388 CRPRGFRFYVRHTEKVQDGTLCQPGSLDICVAGHCLSPGCDGILGSGRRPDGCGVCGGDGSTCRL 452

  Fly   519 ---------------KVTWSKCSRTYLEDFLMDPQAECLF-----DRDSFAGPW------DHTAG 557
                           |:.|.....::|......|.:..|.     .|....|.|      .:.|.
  Rat   453 VSGNLTDRGGPLGYQKILWIPAGASHLRISQFRPSSNYLALRGPGGRSIINGNWAVDPPGSYAAV 517

  Fly   558 G------RLP-----GERFNAN------QQCMLRFGKN----FMQASTQSKMEICRDLHCRQDGL 601
            |      |.|     ||..:|.      ....:.|.::    |.|..|.:..|           .
  Rat   518 GTVFQYNRPPREEGKGETLSAEGPTTQPVDVYMIFQEDNPGVFYQYVTSAAPE-----------S 571

  Fly   602 PWTSHPALE----------------------GT-------------------------------- 612
            |.|..|||:                      ||
  Rat   572 PSTMPPALQLQPEMLRGEPLLPSAPRPVRAPGTLQRQARIPQVPPPTHVRTAMGSSAGYWKQVGH 636

  Fly   613 -----ECGPNMWCRGGTCEARSSKQ---GSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDY 669
                 .||..:|.....|.:|.|.:   ....|:.:.||.. ||:.|.
  Rat   637 SECSASCGKGVWRPIFLCVSRESGEELDEQSCAVGARPPAS-PESCHR----------------- 683

  Fly   670 NPMDNELPGSPSNW--GEWSEPSACESGCLYG-QSRRLL---EGSTGLRTLNRSCLNFPSRCIGR 728
                   |..|..|  |||   ::|...|..| |.|:||   |...|..::.      |.|
  Rat   684 -------PPCPPYWEAGEW---TSCSRSCGPGTQHRQLLCRQEFGGGGSSVP------PER---- 728

  Fly   729 DRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTK 793
                       |..:|...|    ||.|........|::....|        |.:.|   ..|.:
  Rat   729 -----------CGHLPRPNI----TQSCQLRLCGHWEISSPWSQ--------CSVRC---GRGQR 767

  Fly   794 SRRWTFPDGTTCKAKQHNPEDITYCISG--------RCERFSCDNSTSNFFKMDSSFCEARSVRP 850
            ||:      ..|.....:......|.||        .|:...|  :|:.|:...||.|.|
  Rat   768 SRQ------VRCVGSNGHEVGKQECASGPPPPPSREACDMGPC--TTAWFYSDWSSKCSA----- 819

  Fly   851 TRDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPP 915
              :......|:.....|..|..:|.|:....|          ||..:.:
  Rat   820 --ECGTGIQRRAVVCLRSGETLQGDPEAGSTE----------QGCPLRS---------------- 856

  Fly   916 EIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTD-SKGVQG----VTSRL---TGVESIQ 972
               |||...:.||      ...|..|..:.|..|.|.:: ..|.|.    ..|:|   ..|.|..
  Rat   857 ---RPPDMRACSL------GPCEKTWRWYTGPWSECSSECGSGTQHRDIICVSKLGTKFNVTSPS 912

  Fly   973 LCSY-----RIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEP-DRSCRVGCQD-- 1029
            .||:     .:|||:         .|.|.             .|..:::..| .:||:.|.|.
  Rat   913 NCSHLPRPPALQPCQ---------GQACE-------------DQWFSTLWSPCSQSCQGGVQTRE 955

  Fly  1030 -EFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISL 1082
             :.:...:.|    :...||..|  |..||.|....|.:..||.......|..|
  Rat   956 VQCLSSNHTL----SSRCPPHLR--PSRKRPCNSQPCNQRPDDQCKDSSPHCPL 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	47/289 (16%)
		ADAMTS_CR_2	561..625	CDD:465496	19/137 (14%)
		TSP1	683..741	CDD:214559	15/63 (24%)
Adamtsl4	XP_038958286.1	PHA03247	<24..358	CDD:223021	87/409 (21%)
		ADAMTS_CR_3	356..450	CDD:437068	19/108 (18%)
		ADAMTS_spacer1	452..565	CDD:461796	18/112 (16%)
		TSP1_ADAMTS	637..686	CDD:465950	13/73 (18%)
		TSP1_ADAMTS	690..746	CDD:465950	21/83 (25%)
		TSP1_ADAMTS	754..804	CDD:465950	11/66 (17%)
		TSP1_ADAMTS	808..869	CDD:465950	18/102 (18%)
		TSP1_ADAMTS	875..931	CDD:465950	15/64 (23%)
		TSP1_ADAMTS	935..986	CDD:465950	13/56 (23%)
		PLAC	994..1023	CDD:462560	2/10 (20%)