Protein Alignment stl and Adamts3

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_001381638.1
• Gene: Adamts3 / 305253
• RGDID: 1310750
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 1297
• Identity: 280/1297 - (21%)
• Similarity: 419/1297 - (32%)
• Gaps: 455/1297 - (35%)

  Fly    17 IVLTTLWLLIGASSSSSSTSSTN----PKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALI 77
            :|..:|| ||.||.....||:..    .:.|.|:|..||...|..:......|.||...|..:..
  Rat     1 MVFLSLW-LIAASLVEVRTSADGQAGAEEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSAN 64

  Fly    78 FGSRSPEEAPE------FKLV------HLAQQRPEEQ--------QRLEERKRPGEAEQHGGNPH 122
            ...|||.:...      |.:.      || :.||...        :..|...|||...    :|.
  Rat    65 HKKRSPRDVSSNSEQLFFNVTAFGRDFHL-RLRPNTHFIAPGAVVEWHETAPRPGNTT----DPR 124

  Fly   123 QRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQ 187
            ..|..||  |.:|.....|                ||.|...:.|..     ...||
  Rat   125 NSRPHRS--SSEGGWRSEP----------------LQTSCAYVGDIM-----DVPGT-------- 158

  Fly   188 LLKRLERCFYRSPAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGG-- 250
                         :.|:..|:  .:.|:.:.:..:..|.||..          ..::|:..|.
  Rat   159 -------------SVAISNCD--GLAGMIKSDNEEYFIEPLER----------GKQMDEENGRIH 198

  Fly   251 --YSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRR 313
              |..::..|....:...:.::               :|.|:....|.....:.....:...|||
  Rat   199 IVYKRSAMERAPRDVSEDVYYK---------------ESNLEGLDDLGTVYSNIGQQLNETTRRR 248

  Fly   314 RYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPT 378
            |:.|:          .:..||..:.||..:.....|       ..|.::||.::|.|..:||..:
  Rat   249 RHAGE----------NDYNIEVLLGVDDSVVRFHGK-------EHVQNYLLTLMNIVNEIYHDES 296

  Fly   379 LGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKW---QEKLNPFSDADPLHYDHALVLTG 440
            ||..||.||.|:.:........|:...:....|.:.|:|   |:|.:| :.|:  |:|||:.||.
  Rat   297 LGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKSDP-NHAE--HHDHAIFLTR 358

  Fly   441 LDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISC- 504
            .|.     |.|..|  |.|.|.|||..:.|||:|....|.|.||||||.||.|||.||.:...|
  Rat   359 QDF-----GPAGMQ--GYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCG 416

  Fly   505 DPTM--HIMSPKLGSG--KVTWSKCS----RTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLP 561
            |.|.  .:|:|.:.:.  :..||:||    :.|:..:      :||.| |.|...|....  .||
  Rat   417 DETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY------DCLLD-DPFEHDWPKLP--ELP 472

  Fly   562 GERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPW----TSHPALEGTECGPNMWCRG 622
            |..::.::||...||..:...:.....:.|:.|.|.....|:    ...|.|:||||....||..
  Rat   473 GINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYK 537

  Fly   623 GTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWS 687
            |.|..:::.|..                                            ...|||.|:
  Rat   538 GHCMWKNANQQK--------------------------------------------QDGNWGSWT 558

  Fly   688 EPSACESGCLYGQSRRLLEGSTGLRTLNRSC-----LNFPSRCIGRDRRFVTCNTPQCHKVPVQT 747
            :..:|...|           .||:|...|.|     :|....|.|.:..:..|||.:|.|    .
  Rat   559 KFGSCSRTC-----------GTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQK----H 608

  Fly   748 INDFATQVCMQARKSDPELTGEGQQLPSTLDAS---CKIFCRTRTNGTKS-RRWTFPDGTTCKAK 808
            ..||..|.|.|..........:...||.....|   |.::|:::..|..: .:....|||.|..|
  Rat   609 FEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYK 673

  Fly   809 QHNPEDITYCISGRCERFSCDNST-SNFFKM---------DSSFCEARSVRPT------------ 851
              :|..|  |:.|.|.:..||... ||  |:         |:|.|  |:|:.|
  Rat   674 --DPYSI--CVRGECVKVGCDKEIGSN--KVEDKCGVCGGDNSHC--RTVKGTFTRTPRKLGKTR 730

  Fly   852 ---------RDSSDQESRQQTNRQRYAERQEGKPQKNHY----ENEVAKRPSY---G-------- 892
                     |:.|..|:|:..|......:..|     ||    :.|.||..::   |
  Rat   731 GAFVLPKGARNISLAETRETKNVLAIKNQATG-----HYILNGKGEEAKSRTFIDLGVEWDYNIE 790

  Fly   893 ---QGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIAL------DRSSSSESEWVAH---- 944
               :..|.:.|        .|.|               :|.|      |..||...:::.|
  Rat   791 DDIETLHTDGP--------LHDP---------------VIVLIIPQENDTRSSLTYKYIIHEDSV 832

  Fly   945 PGCHSN----------------------------------C--MTDSK----------------- 956
            |..:||                                  |  .:|||
  Rat   833 PTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIR 897

  Fly   957 ---GVQGVTSRLTGVESIQLCS-------YRI------------------------------QPC 981
               .:|..|..|...|:.:.||       |::                              :||
  Rat   898 RMCNIQECTHPLWAAEAWEHCSRSCGSSGYQLRTVRCLQPLQDGTNRSVHSRYCLGERPESRRPC 962

  Fly   982 ERLQTAAEY-------AEQTC---ARYRQKVRGLSGH----------GAQISASIDEP---DRSC 1023
            .|:...|::       ...||   ...||.:.....|          ..|:....|||   |:|
  Rat   963 NRIPCPAQWKTGPWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRACQLPPCNDEPCLGDKS- 1026

  Fly  1024 RVGCQDEFIKYRYYLVNG-----------RNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLP 1074
             :.||.|.:. ||..:.|           |:|..||     |..:..........||..|||
  Rat  1027 -IFCQMEVLA-RYCSIPGYSELCCESCSKRSGTLPP-----PYLQEAAEIHSDAIFGPSDLP 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	73/223 (33%)
		ADAMTS_CR_2	561..625	CDD:465496	19/67 (28%)
		TSP1	683..741	CDD:214559	16/62 (26%)
Adamts3	NP_001381638.1	Pep_M12B_propep	43..201	CDD:460254	37/218 (17%)
		ZnMc_ADAMTS_like	256..457	CDD:239801	73/223 (33%)
		ADAMTS_CR_2	472..540	CDD:465496	19/67 (28%)
		TSP1	554..605	CDD:214559	16/61 (26%)
		ADAMTS_CR_3	611..712	CDD:437068	28/106 (26%)
		ADAMTS_spacer1	714..828	CDD:461796	23/141 (16%)
		TSP1_ADAMTS	850..905	CDD:465950	5/54 (9%)
		TSP1_ADAMTS	910..967	CDD:465950	7/56 (13%)
		TSP1_ADAMTS	971..1016	CDD:465950	6/44 (14%)
		PLAC	1024..1052	CDD:462560	8/30 (27%)