DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts15

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001100280.1	Gene:	Adamts15 / 300474	RGDID:	1309770	Length:	950	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	233/979 - (23%)
Similarity:	353/979 - (36%)	Gaps:	303/979 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LERCFYR-------SPAAALDLCEPGNVRGVFQQNGSDLVIHPLP-------ARFGTGTHVLYQA 242
            |.||||.       ...||:.||  |.:||.|...|::.||.|||       .|...|.|:|
  Rat    98 LRRCFYSGYVNAEPDSFAAVSLC--GGLRGAFGYQGAEYVISPLPNTSAPEAQRHSQGAHLL--- 157

  Fly   243 RVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLR----FQPRHHH 303
                          :|..:|:...          .:|..|....|. .:|..||    ::||...
  Rat   158 --------------QRRGAPVGPS----------GDPTSRCGVASG-WNPAILRALDPYKPRRTG 197

  Fly   304 PHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMIN 368
            ..:.|.:||.   |.|  .|:..||.  ::||.:..|..    |.|....:.|    .:||.::.
  Rat   198 VGESHNRRRS---GRA--KRFVSIPR--YVETLVVADES----MVKFHGADLE----HYLLTLLA 247

  Fly   369 GVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYD 433
            ....||.||::...||.|:.::.:....| .|...:.:....|.:||.||:|||..||..|.::|
  Rat   248 TAARLYRHPSILNPINIVVVKVLLLGDRD-TGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWD 311

  Fly   434 HALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHD 498
            .|::.|..||.    |......:|||.|..||....||::.|.....|.|..|||:||...|.||
  Rat   312 TAILFTRQDLC----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHD 372

  Fly   499 AKEISCDPTM------HIMSPKL--GSGKVTWSKCSRTYLEDFLMDPQAECLFDRDS--FAGPWD 553
            ..:: |:...      |:|||.|  ......||.||...:.|||.....:||.|:.|  ...|.|
  Rat   373 NVKV-CEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPITLPED 436

  Fly   554 HTAGGRLPGERFNANQQCMLRFGKN-----FMQASTQ-------SKMEICRDLHCRQDGLPWTSH 606
                  |||..::.:|||.|.||..     :||..|:       ....:|:..|     .||.
  Rat   437 ------LPGTSYSLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRH-----FPWA-- 488

  Fly   607 PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNP 671
               :||.||...:|..|.|                            :.||.||:.
  Rat   489 ---DGTSCGEGKFCLKGAC----------------------------VERHNPNKY--------- 513

  Fly   672 MDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN-FPSR----CIGRDRR 731
               .:.||   |.:| ||        ||...|...|  |::...|.|.| .|:.    |.|...:
  Rat   514 ---RVDGS---WAKW-EP--------YGPCSRTCGG--GVQLARRQCSNPTPANGGKYCEGVRVK 561

  Fly   732 FVTCNTPQC---------HKVPVQTINDF--ATQVCMQARKSDPELTGEGQQLPSTLDASCKIFC 785
            :.:||...|         .:...:..|.:  :|.....|....|:.:|...:      ..||:.|
  Rat   562 YRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPR------DKCKLIC 620

  Fly   786 RTRTNGTKSRRWTFP---DGTTCKAKQHNPEDITYCISGRCERFSCD---NSTSNFFKM-----D 839
              |.|||.......|   |||.|     .|:..:.|:.|:|.:..||   .|...|.|.     |
  Rat   621 --RANGTGYFYVLAPKVVDGTLC-----TPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGD 678

  Fly   840 SSFCEARS---VRPTR----------DSSDQESRQQTNR-----QRY--AERQEGKPQKN-HY-- 881
            :..|:..:   .:|..          .:|..:.||:..:     ..|  .:..:||...| |:
  Rat   679 NKSCKRVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVV 743

  Fly   882 ---ENEVAKRPSY----GQGNHINA---------PAS-----------PYKRRNYHKPYP----- 914
               |.::..:.|.    |.|..:.:         |.:           |..|.:::.|..
  Rat   744 SAVERDLVVKGSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDK 808

  Fly   915 ---PEIPRPPPPASASLIALDR-----SSSSESEWVAHPG----CHSNC----------MTDSKG 957
               |:.||.||....|:::|..     .:...:.|||  |    |..:|          ..||.|
  Rat   809 SSRPKDPRGPPVLRNSVLSLSNQVEQPDNRPPARWVA--GNWGPCSVSCGSGLQKRAVDCRDSPG 871

  Fly   958 VQGVTSRLTGVESIQLCSYRIQPCERLQTAAE-----------YAEQTCAR-YRQKVRGLSGHGA 1010
            .||:::          |....:|.|: :...|           ...::|.| ::::.....|||.
  Rat   872 QQGISA----------CDVDHRPVEK-RACGEPCPTWELGNWSPCSKSCGRGFKRRPLKCVGHGG 925

  Fly  1011 QISA 1014
            ::.|
  Rat   926 RLLA 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	22/60 (37%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	67/219 (31%)
		Reprolysin	332..545	CDD:279729	68/220 (31%)
		TSP1	683..741	CDD:214559	18/71 (25%)
Adamts15	NP_001100280.1	Pep_M12B_propep	42..157	CDD:279848	22/60 (37%)
		Reprolysin	218..427	CDD:279729	69/224 (31%)
		ZnMc_ADAMTS_like	218..424	CDD:239801	67/221 (30%)
		ADAM_CR	437..506	CDD:301627	23/106 (22%)
		TSP1	519..571	CDD:214559	17/62 (27%)
		ADAM_spacer1	683..801	CDD:283607	16/117 (14%)
		TSP1	846..895	CDD:214559	12/59 (20%)
		TSP1	897..950	CDD:214559	6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810