DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Thsd7b

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_038946352.1	Gene:	Thsd7b / 289007	RGDID:	1306938	Length:	1609	Species:	Rattus norvegicus

Alignment Length:	654	Identity:	123/654 - (18%)
Similarity:	192/654 - (29%)	Gaps:	232/654 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 ISC--DPTMHIMSPKLGSGKVTWSKCSRTYL----------EDFLMDPQAECLFDRDSFAGPWDH 554
            |||  ....:..|.|:|    .||||...:|          :||..|...:......|:......
  Rat   230 ISCPLGKEEYSFSLKVG----PWSKCRLPHLKEAELGGRNVQDFSSDSNEQVTLTHQSYKAQHHS 290

  Fly   555 TAGGRLPGERFNANQ-QCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPWTSHPALEGTECGPNM 618
            ..|....|  |...| .|....|:|.:.:.            |.:|..|.|..|.:...:|..:.
  Rat   291 QPGAIEIG--FQTRQVWCTRSDGRNALLSL------------CMRDSFPLTVQPCVMPKDCETSE 341

  Fly   619 W---------CRGGTCE--ARS-SKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNP 671
            |         ||.||..  .|| |:...:.|:..  .:..||...::....|...:.|
  Rat   342 WSPWSPCSKTCRSGTLSPGVRSRSRNVKHIAIGG--GQECPELLEKETCIAEGEFLQP------- 397

  Fly   672 MDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGS-----TGLRTLNRSCL-NFPSRCIGRDR 730
                .|.......||.|   |:...|..|...|...:     .|::|....|. :||:.
  Rat   398 ----CPRYSWRTSEWKE---CQVSLLLEQQDPLWHKTGPICGGGIQTREVYCAQSFPAT------ 449

  Fly   731 RFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKSR 795
              :|..|.:..: ||:      :.:|:....|..:|              |.:.|.|....:...
  Rat   450 --ITSRTKEVSR-PVE------STLCLGPAPSASQL--------------CNVPCSTDCIVSSWS 491

  Fly   796 RWTFPDGTTCKAKQHNPEDITYCISGRCERFSC-DNSTSNFFKMDSSFCEARSVRPTRDSSDQES 859
            .|                       |.|...:| |......|:|
  Rat   492 AW-----------------------GPCVYENCHDPQGKKGFRM--------------------- 512

  Fly   860 RQQTNRQRYAERQEGKP--------QKNHYENEVAKR---------PSYGQ---GNHINAPASPY 904
                 |||:...:...|        :....|:.:..|         |.:|:   |:.|.......
  Rat   513 -----RQRHVLMESTGPVGHCPHLAESVPCEDPMCYRWLASEGICIPDHGKCGLGHRILKAVCQN 572

  Fly   905 KRRNYHKPYPPEI-----PRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSR 964
            :|..       |:     |.||||...:.....|.....|||.....|..:|  .:|...|..:|
  Rat   573 ERGE-------EVSGGLCPVPPPPERMACEIPCRMDCVVSEWTVWSSCSQSC--SNKNSDGKQTR 628

  Fly   965 LTGVESIQLCSYRIQPCERLQTAAEYA---EQTCAR--YRQKVRGLSGHGAQISA---SID-EPD 1020
            ...:  :.|.....:||...|...||.   :.:||:  :.....|.......::|   ||. ..:
  Rat   629 SRSI--VALAGEGGKPCPGSQELQEYRLCNDHSCAQLYWETSAWGSCSENTLVTALNMSIGWNGE 691

  Fly  1021 RSCRVGCQDEFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQL 1085
            .:|.||.|                     ||     |.:|:               |:|:  ||:
  Rat   692 ATCGVGIQ---------------------TR-----KVFCI---------------KSHV--GQV 713

  Fly  1086 RTRR 1089
            .|:|
  Rat   714 MTKR 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	14/52 (27%)
		Reprolysin	332..545	CDD:279729	14/54 (26%)
		TSP1	683..741	CDD:214559	14/63 (22%)
Thsd7b	XP_038946352.1	TSP1_ADAMTS	44..95	CDD:408800
		TSP1_spondin	180..229	CDD:408798
		TSP1_spondin	337..398	CDD:408798	14/73 (19%)
		TSP1_spondin	602..660	CDD:408798	14/61 (23%)
		TSP1_ADAMTS	665..734	CDD:408800	18/96 (19%)
		TSP1_spondin	738..789	CDD:408798
		TSP1_ADAMTS	1065..1125	CDD:408800
		TSP1_spondin	1131..1177	CDD:408798
		TSP1_spondin	1251..1304	CDD:408798
		TSP1_spondin	1374..1433	CDD:408798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900