Protein Alignment stl and Adamts16

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_742050.2
• Gene: Adamts16 / 271127
• MGIID: 2429637
• Length: 1222
• Species: Mus musculus
• Alignment Length: 1139
• Identity: 271/1139 - (23%)
• Similarity: 409/1139 - (35%)
• Gaps: 352/1139 - (30%)

  Fly    76 LIFGSRSPEEAP--EFKLVHLAQQRPEEQQR--------LE----------ERKRPGEAEQHGGN 120
            |:....|.::.|  ...|...|...||:.|.        ||          |....|:...|...
Mouse    12 LLLAQVSEQQTPACALGLAAAASGSPEDPQPPPFSGSSWLETGEYDLVSAYEVDHRGDYVSHDIM 76

  Fly   121 PHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHS 185
            .:|||:||...::.|...|    ..:..|...:..|.|:.:..|:...|:.....:.||:    |
Mouse    77 HYQRRRRRRAVTQPGGDAL----HLRLKGPRHDLHLDLKAASNLMAPGFMVQTLGKGGTK----S 133

  Fly   186 PQLLKRLERCFYR-------SPAAALDLCEPGNVRGVFQQNGSDLVIHPLP----------ARFG 233
            .|:....|.|||:       :.:.||..|:  .:.|:.:...:|..:.|||          |:..
Mouse   134 VQMFPPEENCFYQGSLRSQGNSSVALSTCQ--GLLGMIRTKDTDYFLKPLPPHLTSKLNRSAQGD 196

  Fly   234 TGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQ 298
            :.:||||:...::                     |...:.|.....|:|..|            :
Mouse   197 SPSHVLYKRSTER---------------------QAPRENEVLMITRKRDLA------------R 228

  Fly   299 PRHHHPH--------QHHQQRRRRYIGDAPRSRWSDIP-------------------EELFIETA 336
            |..||.:        ||...||::|:...|......:|                   |||.:||.
Mouse   229 PHLHHDNFHLGPSQKQHFCGRRKKYMPQPPNDDLYILPDEYKPSSRHKRSLLKSHRNEELNVETL 293

  Fly   337 IFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGL 401
            :.||       :|...::....:.:::|.::|.|..|:...|:|..||.|:..|.:.:. :.|||
Mouse   294 VVVD-------RKMMQSHGHENITTYVLTILNMVSALFKDGTIGGNINIVIVGLILLED-EQPGL 350

  Fly   402 VRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCT 466
            ..|...::.|.|||:||..|   ...|...:|||::|||||:.::.....::  :|.|.:.|||:
Mouse   351 AISHHADHTLTSFCQWQSGL---MGKDGTRHDHAILLTGLDICSWKNEPCDT--LGFAPISGMCS 410

  Fly   467 SIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTM-HIMSPKLG--SGKVTWSKCSRT 528
            ...|||:||.......|.:|||.|||.||.||.:...|..:. :||||.|.  :|..:||.|||.
Mouse   411 KYRSCTVNEDSGLGLAFTIAHESGHNFGMVHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSSCSRQ 475

  Fly   529 YLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRD 593
            ||..||...||.||.|:......:.:..  :|||:.::||.||..:||:.........:.:||:.
Mouse   476 YLHKFLSTAQAICLADQPKPVKEYKYPE--KLPGQLYDANTQCKWQFGEKAKLCMLDFRKDICKA 538

  Fly   594 LHCRQDGLPWTSH--PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIR 656
            |.|.:.|....:.  ||.|||.||.:||||||.| .:...:|             |:.||
Mouse   539 LWCHRIGRKCETKFMPAAEGTLCGQDMWCRGGQC-VKYGDEG-------------PKPTH----- 584

  Fly   657 HEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN- 720
                                    .:|.:||..|.|...|..|.|.|           :|.|.|
Mouse   585 ------------------------GHWSDWSPWSPCSRTCGGGISHR-----------DRLCTNP 614

  Fly   721 FPSR----CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQAR---------KSDPELTGEGQQ 772
            .||.    |.|..|....||:.:|   |:.:: ||....|.:..         |..|....|.|.
Mouse   615 RPSHGGKFCQGSTRTLKLCNSQRC---PLDSV-DFRAAQCAEYNSKRFRGWLYKWKPYTQLEDQD 675

  Fly   773 LPSTLDASCKIFCRTR--------TNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCD 829
            |       ||::|...        :|..|       |||.|.....|     .||.|.|||..||
Mouse   676 L-------CKLYCIAEGFDFFFSLSNKVK-------DGTPCSEDSRN-----VCIDGMCERVGCD 721

  Fly   830 NSTSNFFKMDS-SFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENE---VAKRPS 890
            |...:....|| ..|:..:           |...|:|..|:        |:|..|:   :...||
Mouse   722 NVLGSDATEDSCGVCKGNN-----------SDCVTHRGLYS--------KHHSTNQYYHMVTIPS 767

  Fly   891 YGQGNHI---NAPASPYKRRNYHKPY----------------------------PPEIPRPPPPA 924
            ..:..||   |...|....||..|.|                            .||....|.|.
Mouse   768 GARSIHIYETNISTSYISVRNSLKRYYLNGHWSVDWPGRYKFSGATFNYKRSYKEPENLTSPGPT 832

  Fly   925 SASLI----------------ALDRSSSSES-------EW-VAHPGCHSNC----MTDSKG---- 957
            :.:||                :|.||.:.::       .| :....|..:|    |....|
Mouse   833 NETLIVELLFQGRNPGVAWEFSLPRSGAKKTPAAQPSYSWAIVRSECSVSCGGGKMNSKAGCYRD 897

  Fly   958 ---------VQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYA--EQTC--------------AR 997
                     ....|..:||     |...::.||....:...::  .:||              |.
Mouse   898 LKVPVNASFCNPKTRPVTG-----LVPCKVSPCPSSWSVGNWSVCSRTCGGGTQSRPVRCTRRAH 957

  Fly   998 YRQKVRGLSGHGAQISASI-DEPDRSCRVGCQDE 1030
            ||.:         .|.||: .:|:......|..:
Mouse   958 YRDE---------SIPASLCPQPEPPIHQACNSQ 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	76/214 (36%)
		ADAMTS_CR_2	561..625	CDD:465496	26/65 (40%)
		TSP1	683..741	CDD:214559	19/62 (31%)
Adamts16	NP_742050.2	Pep_M12B_propep	88..203	CDD:460254	26/124 (21%)
		Cysteine switch. /evidence=ECO:0000250	245..253		3/7 (43%)
		ZnMc_ADAMTS_like	288..489	CDD:239801	75/213 (35%)
		ADAMTS_CR_2	506..573	CDD:465496	27/67 (40%)
		TSP1	587..639	CDD:214559	20/65 (31%)
		ADAMTS_CR_3	643..743	CDD:437068	31/130 (24%)
		Spacer	745..871		25/133 (19%)
		ADAMTS_spacer1	745..856	CDD:461796	22/118 (19%)
		TSP1_ADAMTS	929..984	CDD:465950	10/63 (16%)
		TSP1_ADAMTS	988..1045	CDD:465950
		TSP1_ADAMTS	1053..1112	CDD:465950
		TSP1_ADAMTS	1128..1178	CDD:465950
		PLAC	1188..1218	CDD:462560