DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts12

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_780710.2	Gene:	Adamts12 / 239337	MGIID:	2146046	Length:	1600	Species:	Mus musculus

Alignment Length:	817	Identity:	199/817 - (24%)
Similarity:	315/817 - (38%)	Gaps:	209/817 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 NPHQRRQRRSLP--------SEDGNG---------PLPPEEEEQEAG------------EDVEAR 155
            :|.|....:|||        ..|..|         |:....:::.||            |:.:..
Mouse    39 DPRQEHFIKSLPEYHIVSPVQVDAGGHVLSYGLHHPVTSSRKKRAAGGSGDQLYYRISHEEKDLF 103

  Fly   156 LQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSP-----------AAALDLCEP 209
            ..|..:.:.:.:.::..:|..|    :.|...:....:.|..|..           .|||..|:
Mouse   104 FNLTVNWEFLSNGYVVEKRYGN----LSHVKMVASSGQPCHLRGTVLQQGTTVGIGTAALSACQ- 163

  Fly   210 GNVRGVFQQNGSDLVI-----HPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASP------- 262
             .:.|.|.....|..|     |||... |:..||:|:.:         ...:..|..|
Mouse   164 -GLTGFFHLPHGDFFIEPVKKHPLTEE-GSYPHVVYRRQ---------SIRAPETKEPICGLKDS 217

  Fly   263 LDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDI 327
            ||:.::.|...|::.  |:.||::|                       ..||.|.   :.||
Mouse   218 LDNSVKQELQREKWE--RKTLRSRS-----------------------LSRRSIS---KERW--- 251

  Fly   328 PEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEI 392
                 :||.:..|:       |....:....|.|::|.::|.|..|:|.|::|..::.|:.||.:
Mouse   252 -----VETLVVADT-------KTVEYHGSENVESYILTIMNMVTGLFHSPSIGNLVHIVVVRLIL 304

  Fly   393 WKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKG-KANSQVV 456
            .:. :..||......|..|:||||||:.:||.||.:|:|:|.|:::|..|:..   | ....:.:
Mouse   305 LEE-EEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLITRKDICA---GVNRPCETL 365

  Fly   457 GMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPT---MHIMSPKL--G 516
            |::.:.|||....||.|||.......|.:|||:||:.|::||.||..|:|.   .:|||.::  .
Mouse   366 GLSQLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSQQIQYD 430

  Fly   517 SGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQ 581
            ...:||||||:.|:..||...:..||.|..|..|...:...   ||..::.:.||.|::|.|  .
Mouse   431 PTPLTWSKCSKEYITRFLDRGRGFCLDDIPSKKGLKSNVIA---PGVIYDVHHQCQLQYGPN--A 490

  Fly   582 ASTQSKMEICRDLHCRQDGLPWTS-HPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEH 645
            ...|....:|:.|.|...|...:. ..|.:||.||...||..|.|.....|           ||.
Mouse   491 TFCQEVENVCQTLWCSVKGFCRSKLDAAADGTRCGEKKWCMAGKCITVGKK-----------PES 544

  Fly   646 IPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTG 710
            |                                 |..||.||..|.|...|           ..|
Mouse   545 I---------------------------------PGGWGRWSPWSHCSRTC-----------GAG 565

  Fly   711 LRTLNRSCLN----FPSR-CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSD--PELTG 768
            .::..|.|.|    |..: |.|..:|:..||...|.       :|..|...||..:.|  |....
Mouse   566 AQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCR-------SDTPTFRQMQCSEFDTVPYKNQ 623

  Fly   769 EGQQLPSTLDAS--CKIFCRTRTNGTKSRRW-TFPDGTTCKAKQHNPEDITYCISGRCERFSCDN 830
            ..:..| ..:|:  |:::||........|.. ...|||.| .:..|..::  ||:|.|:|..||
Mouse   624 FYRWFP-VFNAAHPCELYCRPIDEQFSERMLEAVIDGTPC-FEGGNSRNV--CINGICKRVGCD- 683

  Fly   831 STSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNRQR 867
                 :::||:..|.|......|.|..::.::..||:
Mouse   684 -----YEIDSNATEDRCGVCLGDGSACQTVKKLFRQK 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	19/99 (19%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	72/217 (33%)
		Reprolysin	332..545	CDD:279729	73/218 (33%)
		TSP1	683..741	CDD:214559	17/62 (27%)
Adamts12	NP_780710.2	Pep_M12B_propep	80..196	CDD:279848	22/122 (18%)
		Cysteine switch. /evidence=ECO:0000250	210..217		1/6 (17%)
		Reprolysin	250..460	CDD:279729	76/228 (33%)
		ZnMc_ADAMTS_like	250..457	CDD:239801	74/225 (33%)
		ADAM_CR	519..680	CDD:301627	52/226 (23%)
		TSP1	549..600	CDD:214559	17/61 (28%)
		Spacer 1	705..831		2/11 (18%)
		ADAM_spacer1	706..816	CDD:283607	2/10 (20%)
		TSP1	832..887	CDD:214559
		TSP1	950..1001	CDD:214559
		Spacer 2	1001..1321
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1006..1140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1179
		TSP1	1430..1478	CDD:214559
		TSP1	1480..1537	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810