DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts14

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001074596.1	Gene:	Adamts14 / 237360	MGIID:	2179942	Length:	1206	Species:	Mus musculus

Alignment Length:	1182	Identity:	260/1182 - (21%)
Similarity:	384/1182 - (32%)	Gaps:	363/1182 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ALIVLTTLWLLIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNT-----LVGHL----- 69
            ||:.....|.....:::.|.|.         :||....||...:.:..:|     .:.|:
Mouse     6 ALLHCLLPWYCALCAAAGSQTP---------DLRLSGKLHDYVVTVPCSTDFQGRFLSHVVSAPA 61

  Fly    70 ----REHERALIFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQH---------GGNP 121
                |.|.|.    :|||          |:.:|        |..|||...||         |...
Mouse    62 APSPRSHLRV----ARSP----------LSLER--------ETPRPGGPRQHFLYFNVTVFGKLL 104

  Fly   122 HQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSP 186
            |.|.|    |:.....|..|.|.:::..|.....||
Mouse   105 HLRLQ----PNRRLVAPGAPVEWQEDFRELFRQPLQ----------------------------- 136

  Fly   187 QLLKRLERCFYRS-----PAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDK 246
                  :.|.|..     |.||:.:.....:.|:.:.:.||..|.||.           :.:.:|
Mouse   137 ------QECVYTGGVTGMPGAAVAISNCDGLAGLIRTDNSDYFIEPLE-----------RGQQEK 184

  Fly   247 SGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQS----QLQSPLRL---RFQPRHHHP 304
            ..||.:....||           |....|:.||...|..::    .|.:.|.|   |
Mouse   185 EAGGRTHVVYRR-----------EAVQREWKEPHGDLHNEAFGLGDLPNVLDLVGDR-------- 230

  Fly   305 HQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMING 369
                       :|||.|.|....|....||..:.||..:.....:....|       ::|.::|.
Mouse   231 -----------LGDAERKRRHAKPGSYSIEVLLAVDDSVVRFHGREHTQN-------YVLTLMNI 277

  Fly   370 VQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKW---QEKLNPFSDADPLH 431
            |..:||..:||..:|..|.||.:........|:...:....|...|:|   |::.:|   :...|
Mouse   278 VDEIYHDESLGAHVNIALVRLIMVGYRQSLSLIERGNPARSLEQVCRWAHSQQRQDP---SHTEH 339

  Fly   432 YDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMR 496
            :||.:.||          :.|....|.|.|.|||..:.||.:|....|.|.||||||.||.|||.
Mouse   340 HDHVIFLT----------RQNFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVVAHETGHVLGME 394

  Fly   497 HDAKEISCDPTM---HIMSPKLGSG--KVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTA 556
            ||.:...||...   .:|:|.:.:.  :..||:||:..|..:|  |..:||.| |.|...|....
Mouse   395 HDGQGNGCDDETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYL--PSYDCLLD-DPFERTWPQPP 456

  Fly   557 GGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPW----TSHPALEGTECGPN 617
              .|||..::.::||...||..:.........|.|:.|.|.....|:    ...|.|:||||.|.
Mouse   457 --ELPGIDYSMDEQCRFDFGTGYHTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPG 519

  Fly   618 MWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSN 682
            .||..|.|..:|                 ||.|:                          |....
Mouse   520 KWCFKGHCIWKS-----------------PEQTY--------------------------GQDGG 541

  Fly   683 WGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPSR-----CIGRDRRFVTCNTPQCHK 742
            |..|:...:|...|           ..|:|:.:|||.|.|..     |.|....:..||:..| .
Mouse   542 WSSWTNFGSCSRSC-----------GGGVRSRSRSCDNPPPAYGGRPCSGSMFEYQICNSEDC-P 594

  Fly   743 VPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDA---SCKIFCRTRTNG-TKSRRWTFPDGT 803
            .|.:   ||..|.|.:..........:...||...|:   .|::.|::...| .........|||
Mouse   595 GPYE---DFRAQQCAKRNSYYTHQDAKHSWLPYEPDSDAQKCELICQSADTGDVVFMNQVVHDGT 656

  Fly   804 TCKAKQHNPEDITYCISGRCERFSCDNSTSNFFKM---------DSSFCEARSVRPT--RDSSDQ 857
            .|..:    :..:.|..|.|..|.||....: .|.         |:|.|  |:|:.|  :.|...
Mouse   657 RCSYR----DPYSVCARGECVPFGCDKEVGS-MKTDDKCGVCGGDNSHC--RTVKGTLGKGSKQA 714

  Fly   858 ESRQQTN-----RQRYAERQEGKPQKNHYENEVAKRPSYGQGNHI-NAPASPYKRRNY------- 909
            .:.:|..     |....|..|..|.:...:|:|.       |:.| |........|.:
Mouse   715 AALKQVQIPAGARHIQIELLEKAPHRIAVKNQVT-------GSFIFNPKGKEASSRTFTALGLEW 772

  Fly   910 -HK------------PYPPEIP---RPP--------------------PPASASLIALDRSSSSE 938
             |:            |.|..|.   .||                    |...::.:.|:.:.:.|
Mouse   773 EHEAEDTKDSLRTNGPLPEAIAILVLPPAEGKPRGSLAYKYVIHEDLLPLIGSNNVLLEETDTYE 837

  Fly   939 ---SEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTC---AR 997
               ..|       |.|   ||...|         .||...|   .|.|.:.........|   .|
Mouse   838 WALKSW-------SPC---SKACGG---------GIQFTKY---GCRRRRDHHMVHRHLCDHKKR 880

  Fly   998 YRQKVRGLSGHGAQISASIDEP----DRSC-RVGCQDEFIKYRYYLVNGRNGHFPP----GTRCS 1053
            .:...|..:.|.......:.|.    .||| ::|.|...::....|.||.:...|.    |.|
Mouse   881 PKPIRRRCNQHSCPQPTWVTEEWGACSRSCGKLGLQTRGVQCLLPLSNGTHKAMPAKACLGNR-- 943

  Fly  1054 PVGKRYCVYGRC 1065
            |..|:.|:...|
Mouse   944 PEAKKPCLRVPC 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	13/88 (15%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	64/219 (29%)
		Reprolysin	332..545	CDD:279729	65/220 (30%)
		TSP1	683..741	CDD:214559	15/62 (24%)
Adamts14	NP_001074596.1	Pep_M12B_propep	80..193	CDD:279848	32/170 (19%)
		ZnMc_ADAMTS_like	246..444	CDD:239801	64/219 (29%)
		Reprolysin	248..447	CDD:279729	66/221 (30%)
		TSP1	542..594	CDD:214559	16/63 (25%)
		ADAM_spacer1	701..816	CDD:283607	21/121 (17%)
		TSP1	836..894	CDD:214559	16/79 (20%)
		TSP1	898..956	CDD:214559	16/60 (27%)
		TSP_1	961..1008	CDD:278517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810