DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts15

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001019310.1	Gene:	Adamts15 / 235130	MGIID:	2449569	Length:	950	Species:	Mus musculus

Alignment Length:	977	Identity:	231/977 - (23%)
Similarity:	350/977 - (35%)	Gaps:	299/977 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LERCFYR-------SPAAALDLCEPGNVRGVFQQNGSDLVIHPLP-------ARFGTGTHVLYQA 242
            |.||||.       ...||:.||  |.:||.|...|::.||.|||       .|...|.|:|
Mouse    98 LRRCFYSGYVNAEPDSFAAVSLC--GGLRGAFGYRGAEYVISPLPNTSAPEAQRHSQGAHLL--- 157

  Fly   243 RVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLR----FQPRHHH 303
                          :|..:|:...          .:|..|....|. .:|..||    ::||...
Mouse   158 --------------QRRGAPVGPS----------GDPTSRCGVASG-WNPAILRALDPYKPRRTG 197

  Fly   304 PHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMIN 368
            ..:.|.:||.   |.|  .|:..||.  ::||.:..|..    |.|....:.|    .:||.::.
Mouse   198 AGESHNRRRS---GRA--KRFVSIPR--YVETLVVADES----MVKFHGADLE----HYLLTLLA 247

  Fly   369 GVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYD 433
            ....||.||::...||.|:.::.:....| .|...:.:....|.:||.||:|||..||..|.::|
Mouse   248 TAARLYRHPSILNPINIVVVKVLLLGDRD-TGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWD 311

  Fly   434 HALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHD 498
            .|::.|..||.    |......:|||.|..||....||::.|.....|.|..|||:||...|.||
Mouse   312 TAILFTRQDLC----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHD 372

  Fly   499 AKEISCDPTM------HIMSPKL--GSGKVTWSKCSRTYLEDFLMDPQAECLFDRDS--FAGPWD 553
            ..:: |:...      |:|||.|  ......||.||...:.|||.....:||.|:.|  ...|.|
Mouse   373 NVKV-CEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPITLPED 436

  Fly   554 HTAGGRLPGERFNANQQCMLRFGKN-----FMQASTQ-------SKMEICRDLHCRQDGLPWTSH 606
                  |||..::.:|||.|.||..     :||..|:       ....:|:..|     .||.
Mouse   437 ------LPGTSYSLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRH-----FPWA-- 488

  Fly   607 PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNP 671
               :||.||...:|..|.|                            :.||.||:.
Mouse   489 ---DGTSCGEGKFCLKGAC----------------------------VERHNPNKY--------- 513

  Fly   672 MDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN-FPSR----CIGRDRR 731
               .:.||   |.:| ||        ||...|...|  |::...|.|.| .|:.    |.|...:
Mouse   514 ---RVDGS---WAKW-EP--------YGSCSRTCGG--GVQLARRQCSNPTPANGGKYCEGVRVK 561

  Fly   732 FVTCNTPQC---------HKVPVQTINDF--ATQVCMQARKSDPELTGEGQQLPSTLDASCKIFC 785
            :.:||...|         .:...:..|.:  :|.....|....|:.:|...:      ..||:.|
Mouse   562 YRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPR------DKCKLIC 620

  Fly   786 RTRTNGTKSRRWTFP---DGTTCKAKQHNPEDITYCISGRCERFSCD---NSTSNFFKM-----D 839
              |.|||.......|   |||.|     .|:..:.|:.|:|.:..||   .|...|.|.     |
Mouse   621 --RANGTGYFYVLAPKVVDGTLC-----TPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGD 678

  Fly   840 SSFCEARS---VRPTR----------DSSDQESRQQTNR-----QRY--AERQEGKPQKN-HY-- 881
            :..|:..:   .:|..          .:|..:.||:..:     ..|  .:..:||...| |:
Mouse   679 NKSCKRVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVV 743

  Fly   882 ---ENEVAKRPSY----GQGNHINA---------PAS-----------PYKRRNYHKPYP----- 914
               |.::..:.|.    |.|..:.:         |.:           |..|.:::.|..
Mouse   744 SAVERDLVVKGSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDK 808

  Fly   915 ---PEIPRPPPPASASLIALDR-----SSSSESEWVAHP--GCHSNC----------MTDSKGVQ 959
               |:.||..|....|:::|..     .:...:.|||..  .|..:|          ..||.|.|
Mouse   809 STRPKDPRGSPVLRNSVLSLSNQVEQPDNRPPARWVAGSWGPCSVSCGSGLQKRAVDCRDSPGQQ 873

  Fly   960 GVTSRLTGVESIQLCSYRIQPCERLQTAAE-----------YAEQTCAR-YRQKVRGLSGHGAQI 1012
            |.::          |....:|.|: :...|           ...::|.| ::::.....|||.::
Mouse   874 GASA----------CDVDHRPLEK-RACGEPCPTWELGNWSPCSKSCGRGFKRRPLKCVGHGGRL 927

  Fly  1013 SA 1014
            .|
Mouse   928 LA 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	22/60 (37%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	67/219 (31%)
		Reprolysin	332..545	CDD:279729	68/220 (31%)
		TSP1	683..741	CDD:214559	18/71 (25%)
Adamts15	NP_001019310.1	Pep_M12B_propep	42..157	CDD:279848	22/60 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..172		7/54 (13%)
		Cysteine switch. /evidence=ECO:0000250	172..179		1/6 (17%)
		Reprolysin	218..427	CDD:279729	69/224 (31%)
		ZnMc_ADAMTS_like	218..424	CDD:239801	67/221 (30%)
		ADAM_CR	437..506	CDD:301627	23/106 (22%)
		TSP1	519..571	CDD:214559	17/62 (27%)
		ADAM_spacer1	683..801	CDD:283607	16/117 (14%)
		Spacer. /evidence=ECO:0000250	701..838		22/136 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		5/23 (22%)
		TSP1	846..895	CDD:214559	11/59 (19%)
		TSP1	897..950	CDD:214559	6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810