DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts17

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001029049.2	Gene:	Adamts17 / 233332	MGIID:	3588195	Length:	1122	Species:	Mus musculus

Alignment Length:	1151	Identity:	266/1151 - (23%)
Similarity:	398/1151 - (34%)	Gaps:	368/1151 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LDKNTLVGHLREHERALIFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQR 124
            ||..|.||                :.|.:.::|...:.|||:   :..:..||.|       ..|
Mouse    21 LDPGTAVG----------------DAAADVEVVLPRRLRPED---VHLQLLPGAA-------GLR 59

  Fly   125 RQRRSLPSEDGNGPLPPEEEEQEAGEDVEA------------RLQLQQSPQLIDDAFIFIRRTEN 177
            |.||...|..|:          .||:...|            .|||.:..:.:...|   ...|.
Mouse    60 RWRRPRASPGGH----------RAGQGERALLLHLPAFGRDLYLQLHRDLRFLSPGF---EVEEA 111

  Fly   178 GTQFVEHSPQLLKRLERCFYRS-----PAA--ALDLC-EPGNVRGVFQQNGSDLVIHPLPARFGT 234
            |.......|     .|.|||..     |.:  :|..| ..|.:.|:.|.....:.|.||
Mouse   112 GVSGRSGHP-----AELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLEQEQVFIQPL------ 165

  Fly   235 GTHVLYQARVDKSGGGY--SEASSRR----TASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPL 293
                      :.|||.:  .|...||    |.||          |.|...||:|.:..::.
Mouse   166 ----------NSSGGPFIGREHLIRRKWASTPSP----------ATEVEGPRQRCKVVTEK---- 206

  Fly   294 RLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESK 358
                :||..|..:..::||     :|.|     :..|..:||.:..|:|:..:       :....
Mouse   207 ----KPRKDHLSRDWRERR-----NAIR-----LTNEHTVETLVVADADMVQY-------HGAEA 250

  Fly   359 VVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEK--- 420
            ...|:|.::|.|..::.|.:||.:||..:.:|.:.:. .|..|......|..|.|||.||.:
Mouse   251 AQRFILTVMNMVYNMFQHRSLGIKINIQVTKLVLLRQ-RPAKLSIGHHGERSLESFCHWQNEEYG 314

  Fly   421 --------LNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAK 477
                    ..|....|....|.|:.:|..|...:.....::  ||:|.:.|:|::...|.:.|..
Mouse   315 GARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVHKDEPCDT--VGIAYLGGVCSAKRKCVLAEDN 377

  Fly   478 HFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGK----VTWSKCSRTYLEDFLMDPQ 538
            .....|.:|||:||||||.||....||....||||.:...|:    ::||.|||..||:||....
Mouse   378 GLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKV 442

  Fly   539 AECLF---DRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKME--ICRDLHCRQ 598
            :.||.   .|...|....|    :|||..::||:||.:.||.|   |:....||  :|..|.|..
Mouse   443 STCLLITDPRSQHALRLPH----KLPGMHYSANEQCQILFGTN---ATFCKNMEHLMCAGLWCLV 500

  Fly   599 DGLPWTS-----HPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWP-PEHIPEATHEKIIRH 657
            :|  .||     .|.|:|||||.:.|||.|.|.:::            | |||:
Mouse   501 EG--DTSCKTKLDPPLDGTECGADKWCRAGECVSKT------------PIPEHV----------- 540

  Fly   658 EPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFP 722
                                  ..:|..||..|.|...|           .||.|...|.|.|.|
Mouse   541 ----------------------DGDWSLWSAWSMCSRTC-----------GTGARFRQRKCDNPP 572

  Fly   723 -----SRCIGRDRRFVTCNTPQCHK-VPVQTINDFATQVCMQARKSDPELTGEGQQLPSTL---D 778
                 :.|.|.......|....|.| ||     .|..|.|    ::...|:.:.:.|.:.:   |
Mouse   573 PGPGGTHCQGASVEHAACEKLPCPKGVP-----SFRDQQC----QAHDRLSSKKRGLLTAVVVDD 628

  Fly   779 ASCKIFCRTRTNGTKSRRWTFP--------DGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNF 835
            ..|:::|...  |.:|     |        |||.|     .|.:...|:.|||::..||....:.
Mouse   629 KPCELYCSPL--GKES-----PLLVADRVLDGTPC-----GPYEADLCVYGRCQKIGCDGIIGSA 681

  Fly   836 FKMD------------------------SSFCE-------ARSVRPTRD-------SSDQESRQQ 862
            .|.|                        :.:.|       ||.:|...|       :....|::.
Mouse   682 AKEDRCGVCSGDGKTCRVVKGDFSHSRGTGYIEAVVIPVGARRIRVVEDKPAHSFLALKDSSKRS 746

  Fly   863 TNRQ----------------RYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHK 911
            .|..                ||..|       ..:|...||.|:...   ::.....:..:||..
Mouse   747 INSDWKIELPGEFQIAGTTVRYVRR-------GLWEKFSAKGPTTVP---LHLMVLLFHDQNYGI 801

  Fly   912 PYPPEIPRPPPPASASLIALDRSSSSESE----------WVAHPGCHSNCMTDSKGVQGVTSRLT 966
            .|...||            :::||.::||          |.     ||       |.:|.:.:..
Mouse   802 HYEYTIP------------VNQSSENQSEPAKPQDALFLWT-----HS-------GWEGCSVQCG 842

  Fly   967 GVESIQLCSYRIQPCERL--QTAAEYAEQTC---ARYRQKVRGLSGHGAQ---ISASIDEPDRSC 1023
            |.|...:.|     |.|:  :|.....:..|   :|...:||..:.|..|   ::........:|
Mouse   843 GGERRTIVS-----CTRIVNKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVTGQWSPCSATC 902

  Fly  1024 RVGCQDEFIKYRYYLVNGRNGHFPPGTRCS---PVGKRYCVYGRCL 1066
            ..|.|...:...|.|.||.:....| ..||   |...:.|....||
Mouse   903 EKGVQHREVTCVYQLQNGTHVTTRP-IYCSEPRPTPVQSCEGQDCL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	20/91 (22%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	65/226 (29%)
		Reprolysin	332..545	CDD:279729	66/230 (29%)
		TSP1	683..741	CDD:214559	16/62 (26%)
Adamts17	NP_001029049.2	Pep_M12B_propep	75..179	CDD:279848	25/127 (20%)
		Reprolysin	230..447	CDD:279729	65/226 (29%)
		ZnMc_ADAMTS_like	230..447	CDD:239801	65/226 (29%)
		TSP1	544..596	CDD:214559	16/62 (26%)
		ADAM_spacer1	698..808	CDD:283607	17/119 (14%)
		TSP_1	892..946	CDD:278517	12/54 (22%)
		TSP1	950..994	CDD:214559
		TSP1	1001..1053	CDD:214559
		PLAC	1080..1106	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810