DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts10

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_766207.2	Gene:	Adamts10 / 224697	MGIID:	2449112	Length:	1104	Species:	Mus musculus

Alignment Length:	1245	Identity:	282/1245 - (22%)
Similarity:	405/1245 - (32%)	Gaps:	440/1245 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 FKLVHLAQQRPEEQQRLE--ERKRPGEAEQHG-----GNPHQRRQRRSLPSEDGNGPLPPEEEEQ 146
            ||:.|..:.:.|....||  |...|...:.:|     ..|..|||||.
Mouse    20 FKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFSPPAFRRQRRG----------------- 67

  Fly   147 EAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQF---VEHSPQLL----------------KRL 192
             ||...|:||              |.:.....|.|   :..||:||                :|.
Mouse    68 -AGATTESRL--------------FYKVAAPSTHFLLNLTRSPRLLAGHVSVEYWTREGLAWQRA 117

  Fly   193 ER--CFYR--------SPAAALDLCEPGNVRGVFQQNGSDLVIHPL---------PARFGTGTHV 238
            .|  |.|.        |...|:..|  |.:.|:...:..:.:|.||         |..  :|.||
Mouse   118 ARAHCLYAGHLQGQAGSSHVAVSTC--GGLHGLIVADDEEYLIEPLQGGPKGHRGPEE--SGPHV 178

  Fly   239 LYQ------ARVDKSGGGYSEASSR------RTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQS 291
            :|:      ..:|.:.|...|...:      ||..|               .|.|.|..:|:
Mouse   179 VYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKP---------------PPARPLGNESE--- 225

  Fly   292 PLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTE 356
                                 |..:| ..||    :..|.::||.:..|..:.|:       :..
Mouse   226 ---------------------RGQLG-LKRS----VSRERYVETLVVADKMMVAY-------HGR 257

  Fly   357 SKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKL 421
            ..|..::||::|.|..|:...:||..:|.::.|| |..:.|.|.|..:......|:||||||:.:
Mouse   258 RDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRL-ILLTEDQPTLEITHHAGKSLDSFCKWQKSI 321

  Fly   422 -------NPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHF 479
                   |...:....::|.|:::|..|:..|......:  :|:|.|.|||....||:|||....
Mouse   322 VSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT--LGLAPVGGMCERERSCSINEDIGL 384

  Fly   480 ESVFVVAHEIGHNLGMRHDAKEISC-----DPTMHIMSPKLGSGKVT-------WSKCSRTYLED 532
            .:.|.:||||||..||.||.....|     ||.      ||.:..:|       ||.|||.|:..
Mouse   385 ATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPA------KLMAAHITMKTNPFVWSSCSRDYITS 443

  Fly   533 FLMDPQAECLFD---RDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKM-EICRD 593
            ||......||.:   |..|..|   |..   ||:.::|::||..:.|..    |.|.|. |:|.:
Mouse   444 FLDSGLGLCLNNRPPRQDFVYP---TVA---PGQAYDADEQCRFQHGVK----SRQCKYGEVCSE 498

  Fly   594 LHC--RQDGLPWTSHPALEGTECGPNM----WCRGGTCEARSSKQGSYSALKSWPPEHIPEATHE 652
            |.|  :.:.....|.||.|||.|..:.    ||....|....|:           ||.:..|
Mouse   499 LWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSR-----------PEGVDGA--- 549

  Fly   653 KIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRS 717
                                          ||.|:....|...|           ..|:.:.:|.
Mouse   550 ------------------------------WGPWTPWGDCSRSC-----------GGGVSSSSRH 573

  Fly   718 CLNFP------SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDP---------ELT 767
            | :.|      ..|:|..||..:|||..|   |..: .||....|.:. .|.|         ...
Mouse   574 C-DSPRPTIGGKYCLGERRRHRSCNTNDC---PPGS-QDFREMQCSEF-DSVPFRGKFYTWKTYR 632

  Fly   768 GEGQQLPSTLDASCKIFCRTR-TNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCDNS 831
            |.|.:       :|.:.|... .|....|.....|||.|:     |:.:..|:||.|:...||..
Mouse   633 GGGVK-------ACSLTCLAEGFNFYTERAAAVVDGTPCR-----PDTVDICVSGECKHVGCDRV 685

  Fly   832 TSNFFKM--------DSSFCEA---------------------------------RSVRPTRDSS 855
            ..:..:.        |.|.||.                                 .|:.......
Mouse   686 LGSDLREDKCRVCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKG 750

  Fly   856 DQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHI----------------------- 897
            ||||       ...|...|.||.:       :.|..|...|:
Mouse   751 DQES-------LLLEGLPGTPQPH-------RLPLAGTTFHLRQGPDQAQSLEALGPINASLIIM 801

  Fly   898 --------------NAPAS-----PYKRRNYHKPYPPEIPRPPPPASASLI-ALDRSSSSESEWV 942
                          |||.:     ||   ::|  |.|........|..|.: .::..:..:|..|
Mouse   802 VLAQAELPALHYRFNAPIARDALPPY---SWH--YAPWTKCSAQCAGGSQVQVVECRNQLDSSAV 861

  Fly   943 AHPGC--HSN-------CMTD---SKGVQGVTSRLT-----GVESIQLCSYRIQPCERLQTAAE- 989
            |...|  ||.       |.|:   ...|.|..||.:     ||.|      |...|:|..:|||
Mouse   862 APHYCSGHSKLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRS------RSVVCQRRVSAAEE 920

  Fly   990 --YAEQTCARYRQKV-RGLSGHGAQIS-ASID--EPDRSCRVGCQDEFIKYRYYLVNG--RNGHF 1046
              ..:..|.:.|..| ....|...... |::|  |...||..|     :::|..|...  :....
Mouse   921 KALDDSACPQPRPPVLEACQGPMCPPEWATLDWSECTPSCGPG-----LRHRVVLCKSADQRSTL 980

  Fly  1047 PPGTRCSPVGK----RYCVYGRC-------LEFGDDDLPLDKTHISLG-QLRTRRKRSSISNDLF 1099
            ||| .|.|..|    ..|...||       .|:|:     ..|...|| |.||.|..|.......
Mouse   981 PPG-HCLPAAKPPSTMRCNLRRCPPARWVTSEWGE-----CSTQCGLGQQQRTVRCTSHTGQPSR 1039

  Fly  1100 NITEIFIKPS 1109
            ..||. ::||
Mouse  1040 ECTEA-LRPS 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	24/121 (20%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	69/230 (30%)
		Reprolysin	332..545	CDD:279729	70/234 (30%)
		TSP1	683..741	CDD:214559	16/63 (25%)
Adamts10	NP_766207.2	Pep_M12B_propep	64..179	CDD:279848	30/150 (20%)
		Reprolysin	239..457	CDD:279729	70/233 (30%)
		ZnMc_ADAMTS_like	239..454	CDD:239801	69/230 (30%)
		TSP1	550..602	CDD:214559	17/66 (26%)
		ADAM_spacer1	706..818	CDD:283607	14/125 (11%)
		Spacer. /evidence=ECO:0000250	706..818		14/125 (11%)
		TSP1	829..885	CDD:214559	13/57 (23%)
		TSP1	952..1003	CDD:214559	15/56 (27%)
		TSP1	1007..1054	CDD:214559	14/48 (29%)
		PLAC	1070..1102	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910