DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stl and THSD7A

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_056019.1	Gene:	THSD7A / 221981	HGNCID:	22207	Length:	1657	Species:	Homo sapiens

Alignment Length:	673	Identity:	118/673 - (17%)
Similarity:	187/673 - (27%)	Gaps:	294/673 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 INEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGKVTWSKCSRTY-------- 529
            :|:|:.:|  .|..|.              .|:..:.:..|        ||.|..|:
Human  1079 VNQAQVYE--VVPCHS--------------DCNQYLWVTEP--------WSICKVTFVNMRENCG 1119

  Fly   530 ---------------------LEDFLMDPQ--------------AECLFDRDSFAGPWDHTAGGR 559
                                 :||:|.||:              .:|:.   |..|||
Human  1120 EGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVI---SEWGPW------- 1174

  Fly   560 LPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPWTSHPALEGTECGPNMWCRGGT 624
                     .||:|.                |.....||........||.||..| ||
Human  1175 ---------TQCVLP----------------CNQSSFRQRSADPIRQPADEGRSC-PN------- 1206

  Fly   625 CEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWG--EWS 687
                        |::..|........|               :|||..|         |.  :.|
Human  1207 ------------AVEKEPCNLNKNCYH---------------YDYNVTD---------WSTCQLS 1235

  Fly   688 EPSACESGCLYGQSRRLLE--GSTGLRTLNRSCLNFPSRCIGRDRRFVTCNTPQCHKVPVQ-TIN 749
            |.:.|.:|.    ..|:|:  .|.|.....:.|     ..:|.::.: ..||....:.||. .::
Human  1236 EKAVCGNGI----KTRMLDCVRSDGKSVDLKYC-----EALGLEKNW-QMNTSCMVECPVNCQLS 1290

  Fly   750 DFA-----TQVC------MQARKSDPELTGEGQQLPSTLDAS--CKIFCRTRTNGTKSRRWTFPD 801
            |::     :|.|      ::.|.......|:|:..||.:|.|  |.:        ....||.:..
Human  1291 DWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPV--------KPCYRWQYGQ 1347

  Fly   802 GTTCKAKQHNPEDITYCISG-RCERFSC---DNSTSNFFK-MDSSFCEARSVRPTRDSSDQESRQ 861
            .:.|:.::      ..|..| |....||   |.|..:|.| :|..||           :|.|...
Human  1348 WSPCQVQE------AQCGEGTRTRNISCVVSDGSADDFSKVVDEEFC-----------ADIELII 1395

  Fly   862 QTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPPPASA 926
            ..|:....|....:|                      .|...|.:
Human  1396 DGNKNMVLEESCSQP----------------------CPGDCYLK-------------------- 1418

  Fly   927 SLIALDRSSSSESEWVAHPGCHSNCMT-DSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEY 990
                         :|.:...|...|:. :..|..|:..|...|...:|.:..:.|.:.|:|.:.|
Human  1419 -------------DWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCY 1470

  Fly   991 AEQTCARYR---------------QKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVN 1040
            ..| |..|:               |:..|::..|..:..|..:.||||...|..
Human  1471 DGQ-CYEYKWMASAWKGSSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPPCSQ----------- 1523

  Fly  1041 GRNGHFPPGTRCSPVGKRYCVYG 1063
                   |.:.||.....:|..|
Human  1524 -------PHSYCSETKTCHCEEG 1539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	17/112 (15%)
		Reprolysin	332..545	CDD:279729	17/114 (15%)
		TSP1	683..741	CDD:214559	13/61 (21%)
THSD7A	NP_056019.1	TSP1	197..247	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..311
		TSP_1	364..412	CDD:301595
		TSP1	1039..>1077	CDD:214559
		TSP1	1290..1340	CDD:214559	11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1570..1591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900