DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Thsd7b

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_011246266.1	Gene:	Thsd7b / 210417	MGIID:	2443925	Length:	1609	Species:	Mus musculus

Alignment Length:	787	Identity:	133/787 - (16%)
Similarity:	234/787 - (29%)	Gaps:	282/787 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 ISC--DPTMHIMSPKLGSGKVTWSKCSRTYL----------EDFLMDPQAECLFDRDSF-----A 549
            :||  ....:..|.|:|    .||||...:|          :||..|...:......|:     :
Mouse   230 VSCPLGKEEYSFSLKVG----PWSKCRLPHLKEVDLSGRNIQDFSSDSNEQVTLTHQSYKAHHHS 290

  Fly   550 GPWDHTAGGRLPGERFNANQ-QCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPWTSHPALEGTE 613
            .|.|...|       |...| .|....|:|.:.:.            |.:|..|.|..|.:...:
Mouse   291 QPGDVVIG-------FQTRQVWCTRSDGRNALLSL------------CVRDSFPLTVQPCVMPKD 336

  Fly   614 CGPNMW---------CRGGTCE--ARS-SKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPP-- 664
            |..:.|         ||.||..  .|| |:...:.|:..  .:..||...::....|...:.|
Mouse   337 CETSEWSPWSPCSKTCRSGTLSPGVRSRSRNVKHIAIGG--GQECPELLEKETCIAEGEFLQPCP 399

  Fly   665 ----------------LLHDYNPMDNE-------------------LPGS--------------- 679
                            ||..::|:.:|                   ||.:
Mouse   400 RYSWRTSEWKECQVSLLLEQHDPLWHETGPICGGGIQTREVYCAQSLPATIASRTKEVSRPVERT 464

  Fly   680 ----------------------PSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFP 722
                                  .|:|..|..       |:: ::....:|..|.|...|..|...
Mouse   465 LCLGPAPSASQLCNVPCSMDCIVSSWSTWGP-------CVF-ENCHDPQGKKGFRMRQRHVLMES 521

  Fly   723 SRCIGRDRRF---VTCNTPQCHK-VPVQTI-----------NDFATQVCMQARKSD--------- 763
            :..:||....   |.|..|.||: :..:.|           :.....||...|..:
Mouse   522 TGPMGRCPHLAESVPCEDPMCHRWLASEGICIADHGKCGLGHRILKAVCQNERGEEVSGGLCPVP 586

  Fly   764 PELTGEGQQLPSTLD---------ASCKIFCRTRTNGTKSRR------WTFPDGTTCKAKQHNPE 813
            |.......::|..:|         :||...|..:.:..|..|      .....|.||.:.|...|
Mouse   587 PPPERMACEIPCRMDCVVSEWTVWSSCSQSCSNKNSDGKQTRSRSILALAGEGGKTCPSSQELQE 651

  Fly   814 DITYCISGRCERFSCDNSTSNFFKMDSSF--CEARSVRPTRDSSDQESRQQT------NRQRYAE 870
                      .|...|:|.:..:...|::  |...::....:.:...:.:.|      .|:.:.
Mouse   652 ----------YRLCNDHSCTQLYWETSAWGSCSENTLVTALNVTIGWNGEATCGVGIQTRKVFC- 705

  Fly   871 RQEGKPQKNHYENEVAKR-PSYGQGNHINAPASPYKRR---NYHKPYPPEIPRPPPPASASL--- 928
                  .|:|....:.|| |...:...:.....|.|:.   .....:.| .|||..|.:.::
Mouse   706 ------IKSHVGQVMTKRCPESTRPETVRPCFLPCKKDCLVTAFSEWTP-CPRPCQPGNTTIKQS 763

  Fly   929 ---IALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLC-SYRIQP-----C--- 981
               |.:..:::...|      |......:.:           .|.|.|| |||.:|     |
Mouse   764 RYRIIIQEAANGGQE------CPDTLFEERE-----------CEDISLCPSYRWKPQKWSSCILV 811

  Fly   982 -ERLQTAAEYAEQTCARYRQKVRGLS-----GHGAQISASIDEPD------RSCRVGCQDEFIKY 1034
             |.::.......:.|.:..| .|.:|     ...|:::..:.:.:      :.|.:.|:|:..
Mouse   812 PESIRQGRTGTSEACGKGLQ-TRAVSCISDDNQSAEMTECLKQMNGMPPLVQECTIPCRDDCT-- 873

  Fly  1035 RYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQL--RTRRKRSSISND 1097
                       |.|.::.:|..|      .|          :.|.|...||  ::|:|.......
Mouse   874 -----------FTPWSKFTPCSK------NC----------EATQIRRRQLTGKSRKKEKCQDAS 911

  Fly  1098 LFNITEI 1104
            |:.:.|:
Mouse   912 LYPLVEM 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	13/52 (25%)
		Reprolysin	332..545	CDD:279729	13/54 (24%)
		TSP1	683..741	CDD:214559	13/60 (22%)
Thsd7b	XP_011246266.1	TSP1_ADAMTS	44..95	CDD:408800
		TSP1_ADAMTS	<137..176	CDD:408800
		TSP1_spondin	180..229	CDD:408798
		TSP1_spondin	337..398	CDD:408798	13/62 (21%)
		TSP1_spondin	602..660	CDD:408798	12/67 (18%)
		TSP1_ADAMTS	665..734	CDD:408800	9/75 (12%)
		TSP1_spondin	738..789	CDD:408798	8/68 (12%)
		TSP1_ADAMTS	1065..1125	CDD:408800
		TSP1_spondin	1131..1177	CDD:408798
		TSP1_spondin	1251..1304	CDD:408798
		TSP1_spondin	1374..1433	CDD:408798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900