DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and T21B6.3

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_509829.2	Gene:	T21B6.3 / 181284	WormBaseID:	WBGene00011880	Length:	821	Species:	Caenorhabditis elegans

Alignment Length:	800	Identity:	149/800 - (18%)
Similarity:	219/800 - (27%)	Gaps:	335/800 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 APEFKLVHLAQQRPEEQQRLEERKRPGEA-----EQHGGNPHQRRQRRSLPSEDGNGPLPPE--- 142
            |||:......||:.|:||| |::.|..:|     :|......|::|:|....:....|.||:
Worm   214 APEYPSAQQQQQQREQQQR-EQQHREHQARLQQHQQQQQQQQQQQQQRPPQPQPQPQPQPPQRPP 277

  Fly   143 ------------------EEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQF-------- 181
                              |::|:..:..:.:.|.||:||         ::.:..|||
Worm   278 QQPQSFSGTHELHLQRQREQQQQQQQQQQQQQQRQQNPQ---------QQPQQTTQFGQSQIQLQ 333

  Fly   182 ----------VEHSPQLLKRLERCFYRSPA---AALDLCEPGNVRGVFQQNGSDLVIHPLPARFG 233
                      .:..||....||    |||.   |.|........|..|.|.      ||.
Worm   334 SGPVPPQQHPQQQQPQQQPELE----RSPLDQHAQLYQQRMSQYRENFNQR------HPA----- 383

  Fly   234 TGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFE-PDAEEFNEPRRRLRAQSQLQSPLRLRF 297
                   :.:.|...||:        .:|:....|.| |.......|......|..|..|...|:
Worm   384 -------RPKADPCPGGF--------CAPVPQAPQQERPTPPPVLAPVINTATQPPLPQPYPTRY 433

  Fly   298 QPRHHHP------------------HQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLY 344
            :|....|                  |.                 |||      ..|......|..
Worm   434 RPAPPPPPACDGQGCVNPPVVSGVWHD-----------------WSD------WSTCSCTCGDGA 475

  Fly   345 AHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVEN 409
            ...::...||.           ..|.........||        ..:.|..|
Worm   476 KSRRRECSTNN-----------CQGADYETEPCNLG--------PCQTWSEW------------- 508

  Fly   410 YLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTIN 474
                 |:|                                         :|....|.|    ...
Worm   509 -----CEW-----------------------------------------STCSASCGS----GQR 523

  Fly   475 EAKHFESVFVVAHEIGHNL--GMRHDAKEISCDPTMHIMSPKLGSGKVTWSKCS----------- 526
            |...|      .| :|.|.  |..:::::.|..|     .|:....: .|.:||
Worm   524 ERTRF------CH-LGTNRCEGKDYESEQCSAGP-----CPEWSQWE-DWGQCSVTCGQGVAVRQ 575

  Fly   527 RTYL-----EDFLMDPQAE---CLFDRDSFAGPWDH------TAGGRLPGERFNANQQCMLRFGK 577
            ||.|     :.....|:.|   |.....|...||..      :.|..:      ..:|.:.:||.
Worm   576 RTCLGGVFGDHLCQGPKTEQRACDGGPCSLWSPWQEWSTCSASCGSGM------KRRQRVCQFGT 634

  Fly   578 NFMQASTQSKMEICRDLHCRQDGLPWTSHPALEG--TECGPNM-----WCRGGTCEARSSKQGSY 635
            :....:.:|  :.|....|.:    ||......|  ::|||..     .|.|...:..::.||
Worm   635 DCQGPNEES--QFCYGPPCAE----WTEWCEWSGCSSKCGPGQRTRTRGCLGPNGQEATTCQG-- 691

  Fly   636 SALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQ 700
                                   |:....|....         |..||.||...|.|:..|..||
Worm   692 -----------------------PSIETTLCEGQ---------SCCNWSEWCHWSMCDKECGGGQ 724

  Fly   701 SRRLLEGSTGLRTLNRSCLNFPS------RCIGRDRRFVTCNT----PQ------CHKVPVQTIN 749
            |         :||  |:|||...      .|.|.||....||:    ||      |...|..|
Worm   725 S---------IRT--RTCLNSAGSPDSSCHCDGPDREEKECNSQSCAPQCAWNTWCEWSPCST-- 776

  Fly   750 DFATQVCMQARKSDPELTGE 769
            ..|.:|.:|:|..  :..||
Worm   777 QLACEVGVQSRSR--QCVGE 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	22/104 (21%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	32/232 (14%)
		Reprolysin	332..545	CDD:279729	32/233 (14%)
		TSP1	683..741	CDD:214559	23/73 (32%)
T21B6.3	NP_509829.2	PAN_AP	35..108	CDD:214680
		TSP1	458..502	CDD:214559	11/85 (13%)
		TSP1	505..552	CDD:214559	15/121 (12%)
		TSP1	554..604	CDD:214559	9/50 (18%)
		TSP1	606..651	CDD:214559	8/52 (15%)
		TSP1	654..704	CDD:214559	12/83 (14%)
		TSP1	707..759	CDD:214559	21/62 (34%)
		TSP1	765..809	CDD:214559	8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900