DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adt-2

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001024532.2	Gene:	adt-2 / 181022	WormBaseID:	WBGene00000083	Length:	1020	Species:	Caenorhabditis elegans

Alignment Length:	1039	Identity:	254/1039 - (24%)
Similarity:	394/1039 - (37%)	Gaps:	263/1039 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LERCFY----RSPAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFG--------TGTHVLYQARV 244
            |:.|.|    ....||:..|: |.::|....:|..:|:||.|....        .|.||:|:..
Worm   104 LDSCHYHHYGEKVYAAISNCD-GRIKGTVIDDGEIIVVHPFPDHHAHRSKRATENGAHVVYKRE- 166

  Fly   245 DKSGGGYSEASSRRTASPLDSQLQFEPDAEE----FNE---PRRRLRAQSQLQSPLRLRFQPRHH 302
                   :.|...:....||:.:..|...|:    |.:   ..:||..||
Worm   167 -------TLAGEPKDFCGLDNVVTEESLVEDESAIFEDVFVTGQRLTQQS--------------- 209

  Fly   303 HPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMI 367
                                       :|.:|.|:|||.:|:.|.........:.|:..:.|.::
Worm   210 ---------------------------DLIVELAVFVDENLWRHFSSKHGGMADRKLQDYTLTLL 247

  Fly   368 NGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLV----RSRDVENYLNSFCKWQEKLNPFSDAD 428
            |.:|::|:.||....:.|.:.|.|: .:..|..|.    ...:.:.||:.||::|..|   :..|
Worm   248 NNIQIMYYQPTASPPLTFRVIRYEV-LTRQPSALAGYLHNHGNAQMYLDRFCRYQRNL---AVRD 308

  Fly   429 PLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNL 493
               :|||::|||.|:   .:|..:..:.|:|.:.|||....:||:.|...|.|.|:..||:||::
Worm   309 ---WDHAIMLTGYDI---HRGAGSRSISGIARLDGMCDPWNTCTLAEGLDFTSAFIGTHELGHSV 367

  Fly   494 GMRHDAKEISCDPTMHIMSPKLGSGKVTWSKCSRTYLEDFL--MDPQAE-CLFDRDSFAGPWDHT 555
            |||||  |..|. :.||||..||.||||||.||......||  :|.:.: ||  |.|........
Worm   368 GMRHD--EPYCQ-SKHIMSSSLGPGKVTWSTCSLRDYHQFLQRLDGRGKNCL--RVSNMPNKLEI 427

  Fly   556 AGGRLPGERFNANQQCMLRFGKNFMQASTQ--SKMEICRDLHCRQD--GLPWTSHPALEGTECGP 616
            :....||:.::||.||.|..|..:.|.:.:  |...||..:.|.|.  |...|||||||||.|||
Worm   428 SSNVKPGQIYDANLQCELMHGNGYQQVTPRQDSYDGICYMMWCGQSSFGRIITSHPALEGTFCGP 492

  Fly   617 NMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELP---- 677
            :.||:.|.|                    :|..        ..|.|.|.:....|:...||
Worm   493 SKWCQLGRC--------------------VPWT--------GTNEIQPTVQHVAPVVTTLPSRID 529

  Fly   678 GSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSC-----LNFPSRCIGRDRRFVTCNT 737
            ||.|.||    .:.|......|     :.||.||....|:|     .|..|.|:|...|.|.|:.
Worm   530 GSWSGWG----ATICSQCTCNG-----ILGSVGLAIARRTCSAPYPANGGSDCVGSTSRAVLCSR 585

  Fly   738 PQCHKVPVQTINDFATQVCMQAR--KSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTF- 799
             ||.:.. ::::::.:..||:.:  |:|.||||:|.||......:||:||..:.:....|.:.|
Worm   586 -QCGRAS-KSVDEYISDKCMEQKRLKNDRELTGKGSQLNRFPQRACKVFCDVQQHYGSQRNYRFF 648

  Fly   800 ----PDGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNFFKMDSSFCEARSVRPTRDSSDQESR 860
                ||||:|...:       ||:.|.|...:|:|:.  ....|.| |...:. |..|.|....|
Worm   649 GDNLPDGTSCGYDR-------YCLDGECLALNCNNNA--LISRDQS-CPTDTC-PITDQSSSVYR 702

  Fly   861 QQ------------TNRQRYAERQE-----GKPQKNHYENEVAKRPS-------------YGQGN 895
            .|            |....|.:|..     |:.:.|..|.||....|             :.:.|
Worm   703 GQWGTWSLWTSCTATCGGGYRKRNRACSITGQCEGNEDETEVCSSESCPSVLRVGNEWSTWTEWN 767

  Fly   896 HINAPASPYKRRNYHKPYPPE--IPRPPPPASASLIALDRSSSSE----SEWVAHPGCHSNC--- 951
            |.:.......:..|.|...|.  :....|..:..:.:.|....:.    ..|.....|.::|
Worm   768 HCSVSCGRGSQARYRKCLSPHRTLAFDCPEKNIEVRSCDNGPCNAIGVWGTWGGWSTCSTSCGPG 832

  Fly   952 ----------------MTDSKGVQGVTSRLTGVESI--------QLCSYRIQP---------CER 983
                            ..:.:.....|.:..|:.|:        ::|...::.         |..
Worm   833 TLVRQRTCNREPCDGSAHERRSCNVATCQNDGIWSLWNEWSDCSRVCGKGLRSRSRSCFGSGCMG 897

  Fly   984 LQTAAEYA-EQTCARYRQKVRGLSGHGAQIS----ASIDEPDRSCRVG-----------CQDEFI 1032
            ..:..::. ||.||.......|.....:|.|    |.:....|:||.|           |.|...
Worm   898 ASSEQQFCNEQACASSSANDWGTWSGWSQCSVSCGAGVKRRTRTCRTGNCPGNYKESAICNDRDC 962

  Fly  1033 KYRYYLVNGRNGHFPPGTRCSP-----VGKRYCVYGRCLEFGD-DDLPLDKTHISLGQLRTRRK 1090
            :.:    |...|.:...:.||.     |.||   ..:|...|: |....:|.:.:|.....|||
Worm   963 ENK----NAAWGGWGYWSSCSETCGDGVRKR---VRKCYGSGNCDGQQYEKQYCNLRVCDFRRK 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	15/58 (26%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	75/218 (34%)
		Reprolysin	332..545	CDD:279729	75/219 (34%)
		TSP1	683..741	CDD:214559	18/62 (29%)
adt-2	NP_001024532.2	Pep_M12B_propep	52..163	CDD:307618	16/59 (27%)
		ZnMc	211..417	CDD:320741	76/220 (35%)
		TSP1	705..751	CDD:214559	9/45 (20%)
		TSP1	760..810	CDD:214559	7/49 (14%)
		TSP1	816..860	CDD:214559	3/43 (7%)
		TSP1	866..910	CDD:214559	5/43 (12%)
		TSP1	918..963	CDD:214559	10/44 (23%)
		TSP1	969..1015	CDD:214559	11/48 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I6918
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115377at33208
OrthoFinder	1	1.000	-	-		FOG0012725
OrthoInspector	1	1.000	-	-		otm14430
orthoMCL	1	0.900	-	-		OOG6_117889
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10543
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820