DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and C36B7.5

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001359920.1	Gene:	C36B7.5 / 180975	WormBaseID:	WBGene00016468	Length:	1148	Species:	Caenorhabditis elegans

Alignment Length:	867	Identity:	163/867 - (18%)
Similarity:	250/867 - (28%)	Gaps:	326/867 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 DPTMHIMSPKLGSGKVT----WSKCSRTYLEDFLMDPQAEC---LFDRDSFAG------------ 550
            |...|:..|...:..|.    ||:||            |.|   |..|....|
Worm   292 DDCYHVAPPGQAAPPVVEWTEWSECS------------ASCGISLRTRQCLGGITCIGPSTIPCQ 344

  Fly   551 -----------PWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLP-- 602
                       ||.........|| ...|:.|  :.|:|....|.:  :|.|:.|      ||
Worm   345 VPECAVWTLWSPWSLCTATCGVGE-IQRNRVC--QTGRNCDGPSVE--VEACKAL------LPCP 398

  Fly   603 -WTSHPALE--GTECGPNM-----WCRGG-----------TCEARS----SKQGSY-SALKSWPP 643
             |:|..:..  |..||.::     .|:.|           ||:.|.    |..|.: ...|....
Worm   399 TWSSWMSWTGCGNSCGKSIERRSRICQNGLLCPGPATEERTCDKRPCPHWSNWGQWEKCSKECGA 463

  Fly   644 EH------------IPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGC 696
            .|            ...|:.|||                 :.|:.| .| .|.:|:..:.|:..|
Worm   464 GHTYRNRECIDGVSCEGASEEKI-----------------LCNQQP-CP-EWSQWTAWTVCDERC 509

  Fly   697 LYGQSRRLLEGSTGLRTLNRSCLNFPSR--CIGRDRRFVTCNTPQCHK-------VPVQTINDFA 752
                      |...:|..||.|:|..:.  |.|..:..::|....|.|       ....|.....
Worm   510 ----------GEESIRLRNRKCMNAENNNACDGPAQDQMSCPYRDCPKWEEWGEWADCSTTCGQG 564

  Fly   753 TQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTFPDGTTCKAKQHNPEDITY 817
            ||..::...|..|.:|.|:::.....|||..:          ..||...|.:....|...|....
Worm   565 TQKRLRKCDSGNECSGPGEEMRFCQIASCPYW----------GDWTPWSGCSVSCGQGVCERTRK 619

  Fly   818 CISGR------CERFSCDNSTSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNRQRYAERQEG-- 874
            ||:..      .|....|:|.......::....|:::...|.::  |:|....|....|.|.|
Worm   620 CITDEFLQLPTLEELERDDSLEKHEAKEALIARAKTISKYRRTN--ETRLSPFRPLSPEPQLGGT 682

  Fly   875 --KPQKNHYENEVAK-------------RPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPP-- 922
              .|:   .|.:|..             .|..|.||      ....:||.......:.|.|||
Worm   683 CDGPE---METKVCDAGPCCVWNRWTEWSPCIGCGN------EGISKRNRVCSMEGQSPAPPPIS 738

  Fly   923 ------------------------PASASLIALDRSSSSESEWV---AHPGCHSNCMTDSKGVQG 960
                                    |..:.::.::..........   |.|.||  |..|:...:.
Worm   739 FQDNPRGTYVTASLGQGPIGPNILPGMSPIVPVEIHRGKRQVLFGIQATPKCH--CPGDTFQTRP 801

  Fly   961 VTSRLTGVESIQLCSY----------RIQP--------CER----------------------LQ 985
            ...:....:.:..|.:          |.:|        |:|                      .|
Worm   802 CLEQNACQDPVGKCEWSEWGEWCGCMRCRPGKEVRRRFCDRSPIGRGGPMRPDSTCDCGNGDDSQ 866

  Fly   986 TAAEYAEQTC------------------ARYRQKVRGLSGHGAQISA------SIDEPDRSCRVG 1026
            ..:...||||                  ||.||..||.:|.....:|      |.:...|.....
Worm   867 ERSCPMEQTCYGNGIGTGRFNNAASMQDARERQNFRGRTGSFYNTAAPQRDRTSYNSNRRPSHSR 931

  Fly  1027 CQDEFIKY-----RYYLVNGR---------------NGHFP----------PGTRC----SPVGK 1057
            .|||::..     |..|.:|:               ...||          ..:||    :...|
Worm   932 SQDEYVPIDSVIGRVQLRSGKEPQSYNKKDNAEAFETTEFPYKVCHWSKWSEWSRCHDNSTRERK 996

  Fly  1058 RYCVYGR---------CLEFGDDDLPLDKT-HISLGQLRTRRKRSSISNDLFNITEIFIKPSHSD 1112
            |:||..:         ||....::.|.:.| .|......|.|:   |.|:|..:.|       .|
Worm   997 RFCVGEKGSELVSNCECLGKPHEEEPCNATGFIEQSNEETDRE---IENNLDKLLE-------ED 1051

  Fly  1113 ISAENIEFTQPIHVSADELSSK 1134
            .:..::|    :|...:||.||
Worm  1052 NAGGDVE----LHKKKEELKSK 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	10/44 (23%)
		Reprolysin	332..545	CDD:279729	11/46 (24%)
		TSP1	683..741	CDD:214559	13/59 (22%)
C36B7.5	NP_001359920.1	TSP1	309..348	CDD:214559	9/50 (18%)
		TSP1	351..398	CDD:214559	14/57 (25%)
		TSP1	400..446	CDD:214559	10/45 (22%)
		TSP1	448..494	CDD:214559	10/63 (16%)
		TSP1	496..546	CDD:214559	13/59 (22%)
		TSP1	548..594	CDD:214559	9/45 (20%)
		TSP1	596..>621	CDD:214559	5/34 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910