DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adt-3

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_508681.3	Gene:	adt-3 / 180675	WormBaseID:	WBGene00020567	Length:	940	Species:	Caenorhabditis elegans

Alignment Length:	971	Identity:	261/971 - (26%)
Similarity:	388/971 - (39%)	Gaps:	273/971 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPAAA-----LDLCEPGN-VRGVF 216
            |:..|.|..:.:..:   ||..:.:.|.      |:.|.|...:|.     :.|...|| :.|:.
Worm    73 LRNKPHLFSEGYHIM---ENDVELMMHP------LKDCVYEGESAVRNGTRIGLVGCGNKMNGMV 128

  Fly   217 QQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRR 281
            ..:..|  .|.:.:...||.||::                :|:...:|.:.||:.:.:.:.|.|.
Worm   129 VADNGD--YHLIQSHHQTGHHVIH----------------KRSIESIDHECQFDANEDPYPEDRE 175

  Fly   282 RLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAH 346
            .:..:|.|   :|:....|...||:.                  ||   |.:|.|:|.|..::.|
Worm   176 EIAMKSML---IRMVKDIRRAEPHRR------------------DI---LTVELAVFADDAMWDH 216

  Fly   347 MQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSR-----D 406
            .:|.:....|..:.:|::|::|.:.:||....|..|||..:.|.||.|  :.|.|:.:|     |
Worm   217 FKKMYGKAAEENMHTFIMAVVNNIDVLYTQRLLQPRINIKIVRYEILK--NIPHLMNARKHSNGD 279

  Fly   407 VENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSC 471
            |:..|::||::|.::||.:||||.|:||||:.:|.||  :..|.  ..|.|.|.|||||:.:.||
Worm   280 VDRLLDAFCQYQNEINPPNDADPRHWDHALLFSGYDL--HRNGV--KTVAGYAPVKGMCSGVRSC 340

  Fly   472 TINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGKVTWSKCSRT-------Y 529
            ||||...|.|||||.||:||:|||.||. :..||....||||.:||||..||:||..       :
Worm   341 TINEGLDFGSVFVVTHEMGHSLGMYHDG-DNECDLRCCIMSPSVGSGKTHWSQCSVNEMATFVGH 404

  Fly   530 LEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQ--ASTQSKMEICR 592
            |.|....|  .||.|..:.............||:.|..::||.:..|:.:..  ...|:...||:
Worm   405 LGDDFRPP--NCLQDASANEQRMVAFKESEPPGQLFTLDEQCEIFHGECWKHELKDGQTMQNICQ 467

  Fly   593 DLHC-RQDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQ----GSYSALKSWPPEHIPEATHE 652
            .:.| ..:|:..|:|||||||.||..|.||.|.|...|...    |.:|   :|
Worm   468 MVWCGNGEGVIRTAHPALEGTYCGFGMICRQGQCVGSSQLMRVTVGGWS---TW----------- 518

  Fly   653 KIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRS 717
                                 |:.| :|:..|..|:   ||   :.||.|.       :|:: |.
Worm   519 ---------------------NDRP-APTCGGRCSQ---CE---IRGQIRI-------MRSI-RQ 547

  Fly   718 CLNFPSR------CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSD--PE--LTGEGQQ 772
            | |.||.      |.|.:.|.:.|:...|:.   .:|.::||:||.:.|..:  |.  |:|||.|
Worm   548 C-NNPSSNNGGAPCQGDEARGMVCHRDVCNG---DSIENYATRVCSRLRDENAIPNTILSGEGMQ 608

  Fly   773 LPSTLDASCKIFC--------RTRTNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCD 829
            ..   .|.|||:|        ||.:|        ||||..|...|       |||.|.|....|.
Worm   609 FE---QAMCKIWCLISGSTNIRTVSN--------FPDGAPCGPGQ-------YCIKGECRPLLCG 655

  Fly   830 NSTSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQG 894
            ::|..:.:.|   |....::.|.                      .|...|..:.
Worm   656 STTLAYSEAD---CPLSVLQTTT----------------------TPPMPHVHSV---------- 685

  Fly   895 NHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQ 959
            :......:|||.   ||..|                .....|..|.|       |.|:|.....|
Worm   686 DQFAGKTNPYKE---HKKTP----------------FLNEWSGWSVW-------SECVTYDCHTQ 724

  Fly   960 GVTSR----LTGVESIQLCSYRI---QPCERLQTAAEY------AEQTCARYRQK-VRGLSGHGA 1010
            ||..|    |.||     |:..:   |||.|..|.:|.      .:||   :|.: :..|.....
Worm   725 GVKVRVRRCLAGV-----CAGALRERQPCTRPCTGSERPLTTSPPQQT---FRNRFIAPLPNRQT 781

  Fly  1011 -QISASIDE--PDRSCRVGC-QDEFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLE 1067
             .|...:|.  |..:|.|.| ..:.::.|...:         |..|:..|.  ||...|.|
Worm   782 NMILRKVDHWGPWSACSVTCGTGQKLRRRENCI---------GQECAETGP--CVMQSCRE 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	19/86 (22%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	92/223 (41%)
		Reprolysin	332..545	CDD:279729	92/224 (41%)
		TSP1	683..741	CDD:214559	17/63 (27%)
adt-3	NP_508681.3	ZnMc_ADAMTS_like	201..416	CDD:239801	92/223 (41%)
		ADAM_CR_2	434..502	CDD:375321	25/67 (37%)
		TSP_1	<699..751	CDD:387593	19/79 (24%)
		TSP1	791..829	CDD:214559	10/48 (21%)
		TSP1	836..881	CDD:214559
		TSP1	896..940	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I2423
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	236	1.000	Inparanoid score	I2142
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115377at33208
OrthoFinder	1	1.000	-	-		FOG0012725
OrthoInspector	1	1.000	-	-		otm14430
orthoMCL	1	0.900	-	-		OOG6_117889
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10543
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730