Protein Alignment stl and ADAMTS19

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_047272832.1
• Gene: ADAMTS19 / 171019
• HGNCID: 17111
• Length: 1228
• Species: Homo sapiens
• Alignment Length: 1201
• Identity: 262/1201 - (21%)
• Similarity: 399/1201 - (33%)
• Gaps: 388/1201 - (32%)

  Fly    17 IVLTTLWLLIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALIFGS- 80
            :|...||.......:..|..|.:|..|       |.:...|              ..||...||
Human    43 VVFPALWRREPVDPAGGSGGSADPGWV-------RGVGGGG--------------SARAQAAGSS 86

  Fly    81 ---RS----PEEAP-----EFKLVHLAQQRPEEQQRLEERKRP----GEAEQHGGNPHQRRQRRS 129
               ||    |.|.|     |.:|........||.:.||.::.|    |.|....|.|  ...:..
Human    87 REVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEELESQELPRGSSGAAALSPGAP--ASWQPP 149

  Fly   130 LPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTEN----------------G 178
            .|.:....| ||.:..:..|::|..|:     |....|.::.:||...                |
Human   150 PPPQPPPSP-PPAQHAEPDGDEVLLRI-----PAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPG 208

  Fly   179 TQFVEHSPQLLKRLER-CFY-----RSPA--AALDLCEPGNVRGVFQQNGSDLVIHPLPARFG-T 234
            ......:||.....:. |||     |.|.  |:...| .|.:.|..|.|...:.|.||..... |
Human   209 PTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTC-GGGLMGFIQLNEDFIFIEPLNDTMAIT 272

  Fly   235 G-THVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQ 298
            | .|.:|:                                     .:|.:..:...:|.|
Human   273 GHPHRVYR-------------------------------------QKRSMEEKVTEKSAL----- 295

  Fly   299 PRHHHPHQHH-------QQRRRRYIGDAPR-SRWS-DIPEELFIETAIFVDSDLYAHMQKNFPTN 354
                  |.|:       .:.|.|.|.::.| .|:| .:|:|..|||.:..|..:.::       :
Human   296 ------HSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSY-------H 347

  Fly   355 TESKVVSFLLAMINGVQLLYHHPTLGRRINF-VLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQ 418
            .......|:|.::|.|..|:.|.:|..::|. |:|.:.:.::  ||.|......|..|.||||||
Human   348 GADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHET--PPELYIGHHGEKMLESFCKWQ 410

  Fly   419 EKLNPFSDADPLH-------------YDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYS 470
            .:  .|...:.:|             .|.|:::|..|...:.....::  ||:|.:.|||:....
Human   411 HE--EFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDT--VGIAYLSGMCSEKRK 471

  Fly   471 CTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPK----LGSGKVTWSKCSRTYLE 531
            |.|.|.......|.:|||:|||:|:.||....||...:||||.:    ...|.|:||:||:..||
Human   472 CIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLE 536

  Fly   532 DFLMDPQAECLFDR-----DSFAGPWDHTAGGRLPGERFNANQQCMLRFG--KNFMQASTQSKME 589
            .||....:.||...     :|...|      .:|||..:.|::||.:.||  .:|.| ..|.|::
Human   537 RFLRSKASNCLLQTNPQSVNSVMVP------SKLPGMTYTADEQCQILFGPLASFCQ-EMQVKIQ 594

  Fly   590 --ICRDLHCRQDG---LPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEA 649
              ||..|.|:.:|   ......|.::||:|....||:.|.|.:|:|           .|||:.
Human   595 HVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTS-----------APEHLA-- 646

  Fly   650 THEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTL 714
                                              ||||..|.|...|           |.|:.:.
Human   647 ----------------------------------GEWSLWSPCSRTC-----------SAGISSR 666

  Fly   715 NRSCLNFPSR---CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPST 776
            .|.|....|.   |.|..:::..|..|.| ...:....|:..| ....|.|.|:...:.|   :.
Human   667 ERKCPGLDSEARDCNGPRKQYRICENPPC-PAGLPGFRDWQCQ-AYSVRTSSPKHILQWQ---AV 726

  Fly   777 LDAS--CKIFCRTRTNGTKSRRWTFP--------------DGTTCKAKQHNPEDITYCISGRCER 825
            ||..  |.:||.             |              |||:|     ..:.:..|.:|||::
Human   727 LDEEKPCALFCS-------------PVGKEQPILLSEKVMDGTSC-----GYQGLDICANGRCQK 773

  Fly   826 FSCDNSTSNFFKMD----------------SSFCEAR------------SVRPTRDSSDQESRQQ 862
            ..||....:..:.|                ..|...|            ..|..:...::.:...
Human   774 VGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSY 838

  Fly   863 TNRQRYAERQE------GKPQKN------------------HY------ENEVAKRPSYGQGNHI 897
            .....|..|::      ||...|                  ||      |...||.|:
Human   839 LGNLCYRHREDPTLRDAGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPT------- 896

  Fly   898 NAP----ASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESE----W--VAHPGCHSNCM 952
            .||    ...::.:||...|...||..|.|        :..||...|    |  .:...|.:.|
Human   897 TAPLHLLVLLFQDQNYGLHYEYTIPSDPLP--------ENQSSKAPEPLFMWTHTSWEDCDATC- 952

  Fly   953 TDSKGVQGVTSRLTGVESIQL-------CSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGA 1010
              ..|.:..|...|.:.|..:       |.|..:|..:::   :..||.|     :.|.:.....
Human   953 --GGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIR---KCNEQPC-----QTRWMMTEWT 1007

  Fly  1011 QISASIDEPDRSCRVGCQDEFIKYRYYLVNG 1041
            ..|       |:|..|.|...:.....|.||
Human  1008 PCS-------RTCGKGMQSRQVACTQQLSNG 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	67/229 (29%)
		ADAMTS_CR_2	561..625	CDD:465496	23/70 (33%)
		TSP1	683..741	CDD:214559	16/60 (27%)
ADAMTS19	XP_047272832.1	Pep_M12B_propep	163..279	CDD:460254	27/121 (22%)
		ZnMc_ADAMTS_like	331..548	CDD:239801	67/229 (29%)
		ADAMTS_CR_2	565..636	CDD:465496	23/71 (32%)
		TSP1	647..696	CDD:214559	17/60 (28%)
		ADAMTS_CR_3	<733..799	CDD:437068	15/83 (18%)
		ADAMTS_spacer1	801..921	CDD:461796	19/126 (15%)
		TSP1_ADAMTS	940..997	CDD:465950	12/62 (19%)
		TSP1_ADAMTS	1001..1057	CDD:465950	8/38 (21%)
		TSP1_ADAMTS	1061..1103	CDD:465950
		TSP1_ADAMTS	1112..1164	CDD:465950