DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Papln

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	1242	Identity:	242/1242 - (19%)
Similarity:	355/1242 - (28%)	Gaps:	530/1242 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 RKRPGEAEQHGG--------NPHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEAR----LQLQQ 160
            |:||..:::..|        ..|:.....|.|  ||......|:..:..|.|.:.|    |....
Mouse    50 RERPCYSQRRDGGTSCVGPARSHRTCHTESCP--DGVRDFRAEQCAEFDGTDFQGRRYRWLPYYA 112

  Fly   161 SPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPAAALD--LCEPGN----VRGVFQQN 219
            :|...:     :.....|..|              :|:...|.:|  .||||.    |.||.:..
Mouse   113 APNKCE-----LNCIPKGQNF--------------YYKHKDAVVDGTPCEPGQRDICVDGVCRVV 158

  Fly   220 GSDLVIHPLPARFGTGTHVLYQARVDKSGG-------------------GYSE------------ 253
            |.|   |.|.:       :..:.:..:.||                   ||::
Mouse   159 GCD---HKLDS-------IKQEDKCLQCGGDGSSCYPVTGTFDGNDLSRGYNQIFIIPAGATSIR 213

  Fly   254 ----ASSRR----------------------TASPLDSQ-LQFEPDAEEFNEPRRRLRAQSQLQS 291
                |:||.                      .|.|:.|. ||:|...|....| .||:|:.....
Mouse   214 IEEAAASRNFLAVKSIRGEYYLNGHWTIEAAQALPVASTVLQYERGVEGDLAP-ERLQARGPTSE 277

  Fly   292 PLRLRFQPRHHHPHQHHQQRRRRYI--GDAPR------SRWSDIPEEL---FIETAIF--VDSDL 343
            ||.:....:..:|..|::.    |:  .|..|      ..|.|...|.   .....:|  :|::.
Mouse   278 PLVIELLSQESNPGVHYEY----YLPANDPGRGFSWSHGSWGDCSAECGGGHQSRLVFCTIDNEA 338

  Fly   344 YA-HMQKNFPTNT-----------ESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWK-- 394
            |. ||.::.|..|           ::|.:|||           |.|...|...........||
Mouse   339 YPDHMCQHQPRPTHRRSCNTQPCPKTKRISFL-----------HRPGAWRYAGVQHMCGNSWKVG 392

  Fly   395 SWDP-----PGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQ 454
            .|.|     .|.|:||.|      :|       ..||.           ||        |:..::
Mouse   393 PWTPCSVSCGGGVQSRSV------YC-------ISSDG-----------TG--------GQEAAE 425

  Fly   455 VVGMATVKGMCTSIYSCTINEAKHFESVFVVA--HEIGHNLGMRHDAKEISC------------- 504
            ....|.:.|...:..:|.:...    :|:.|.  .|.....|.....:.::|
Mouse   426 ETQCAGLVGKPPTTQACNLQHC----AVWSVEPWGECSVTCGTGIRKRSVTCRGDEGSPVHAAAC 486

  Fly   505 ---------DPTMHIMSP-------KLGSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWD 553
                     :|.:....|       .:||    ||.||:: ....:...|..|..      ||
Mouse   487 LLKDQPTLTEPCVQEACPVFRGQAWHVGS----WSLCSKS-CGSGIRRRQVVCTI------GP-- 538

  Fly   554 HTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCR--------QDGLPWTSHP-AL 609
                   ||       :|:      .:|:|..::||.|....|.        ||....:|.| .|
Mouse   539 -------PG-------RCV------DLQSSKPAEMEACNRQPCHLPQEVPSIQDPRTRSSDPRML 583

  Fly   610 EGTECGP------NMWCRGGTCEARSS-KQGSYSALKS--------WPPEHIP--EATHEKIIRH 657
            .|....|      ..|.......|:|: ::|....|.|        .||...|  .::..:..||
Mouse   584 SGPRVSPVSDGREQQWAPLERPRAQSNPREGQDPNLSSAGRAPTLQRPPHQPPLRPSSGPRDCRH 648

  Fly   658 EPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSR--------RLLEG------- 707
            .|:...|..|           :||...:|.......:.||  |||        ...||
Mouse   649 SPHGCCPDGH-----------TPSLGPQWQGCPLAGASCL--QSRYGCCPDGVSAAEGPQQAGCT 700

  Fly   708 ------STGLRTLNRSCLN-------------FPSRCIGRDRRFVTC--NTPQC----------- 740
                  :||.|..:|:..:             .||.|  |..||..|  |....
Mouse   701 RSHGSDNTGNRPGSRAVASKNPKIHQPQAHEGEPSEC--RSSRFGCCYDNVASAAGPLGEGCVGQ 763

  Fly   741 --HKVPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTFPDGT 803
              :..||:         |:               |||. ..||         |..:.||.|....
Mouse   764 PSYAYPVR---------CL---------------LPSA-QGSC---------GDWAARWYFVASV 794

  Fly   804 TCKAKQHNPEDITYCISGRCERF---SCDNSTSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNR 865
                             |||.||   .|..:.:||                  :|:||.......
Mouse   795 -----------------GRCNRFWYGGCHGNANNF------------------ASEQECMNTCRG 824

  Fly   866 QRYAERQEGKPQKNHYENEVAKRPSYGQGN-----------HINAPA-SPYKRRNYHKP-YPPEI 917
            |....|.|.....:....:..:|...||..           .:.:|: ||::|.....| .||.|
Mouse   825 QHGPRRPEAGAAGHRAHVDGGQRGPGGQQEPDWHRAGATIPRLPSPSGSPWRREQEPAPGEPPHI 889

  Fly   918 P-----------RPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESI 971
            |           ||..|      .|||.:..     |.|..||.
Mouse   890 PAYGNRPGGQEIRPRVP------GLDREARP-----AVPPTHSP--------------------- 922

  Fly   972 QLCSYRI-----QPCERLQTAAEYAEQT-C---------ARYRQKVRGLSGHGAQISAS------ 1015
               ||||     :| ..:|.|...|.|. |         |.::::.|.:|.:..|:.|.
Mouse   923 ---SYRIRLAGSEP-SLVQAAPGQAVQLFCPGNIPSEFQAGWQKEGRPISSNRYQLQADGSLIIS 983

  Fly  1016 ----IDEPDRSC---RVGCQDEFIKYRYYLVNG-----------------RN---GHFPP--GTR 1051
                .|....||   |.|.:.:.|:.|   |.|                 ||   ||.||  ||.
Mouse   984 RLRPEDAGIYSCGSHRPGHEPQEIQLR---VTGGDMAVFPEGQPRHFPEPRNPDLGHGPPHRGTG 1045

  Fly  1052 CSPVGKR 1058
            ....|.|
Mouse  1046 AEAGGHR 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	19/93 (20%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	47/266 (18%)
		Reprolysin	332..545	CDD:279729	47/264 (18%)
		TSP1	683..741	CDD:214559	20/106 (19%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559	6/30 (20%)
		ADAM_spacer1	184..299	CDD:368694	21/119 (18%)
		TSP1	309..362	CDD:214559	10/52 (19%)
		TSP1	389..447	CDD:214559	18/89 (20%)
		TSP1	447..504	CDD:214559	6/60 (10%)
		TSP1	511..562	CDD:214559	18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648		16/84 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737		6/42 (14%)
		Kunitz_BPTI	771..822	CDD:333766	21/119 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924		25/136 (18%)
		Papilin_u7	831..922	CDD:374683	22/101 (22%)
		Ig	932..>995	CDD:386229	12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064		10/29 (34%)
		I-set	1070..1141	CDD:369462
		Ig	1157..1241	CDD:386229
		PLAC	1257..1289	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900