DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and ADAMTS18

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_955387.1	Gene:	ADAMTS18 / 170692	HGNCID:	17110	Length:	1221	Species:	Homo sapiens

Alignment Length:	1129	Identity:	263/1129 - (23%)
Similarity:	396/1129 - (35%)	Gaps:	347/1129 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 HQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEAR-------LQLQQSPQLIDDAFIFIRRTENGT 179
            |..|::||               .|.|...:..|       |.|:..|..|..:...::......
Human    82 HNGRKKRS---------------AQNARSSLHYRFSAFGQELHLELKPSAILSSHFIVQVLGKDG 131

  Fly   180 QFVEHSPQLLKRLERCFYR-------SPAAALDLCEPGNVRGVFQQNGSDLVIHPLP-------- 229
            ......|:    :::|||:       |.:.|:..|  ..:.|:.:...::.:|.|||
Human   132 ASETQKPE----VQQCFYQGFIRNDSSSSVAVSTC--AGLSGLIRTRKNEFLISPLPQLLAQEHN 190

  Fly   230 --ARFGTGTHVLYQARVDKSGGGYS--EASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQ 290
              :..|...||||:...::....|.  ..|.|.......|.:.....:.|.....|||:
Human   191 YSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQ------ 249

  Fly   291 SPLRLRFQPRHHHPHQHHQQRRRRY---------------IGDAPRSRWS--DIPEELFIETAIF 338
                          .||...||::|               .|.:.|.|.|  ...:.|.:||.:.
Human   250 --------------KQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV 300

  Fly   339 VDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVR 403
            .|       :|....:.:..|.:::|.::|.|..|:...|:|..||.|:..| |....:|.||:.
Human   301 AD-------KKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSL-ILLEQEPGGLLI 357

  Fly   404 SRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSI 468
            :...:..|||||:||..|   ...:...:|||::|||.|:.::.....::  :|.|.:.|||:..
Human   358 NHHADQSLNSFCQWQSAL---IGKNGKRHDHAILLTGFDICSWKNEPCDT--LGFAPISGMCSKY 417

  Fly   469 YSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTM-HIMSPKL--GSGKVTWSKCSRTYL 530
            .||||||.......|.:|||.|||.||.||.:...|.... :||||.|  .:|..:||.|||.||
Human   418 RSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYL 482

  Fly   531 EDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLH 595
            :.||..|||.||.|....||.:.:.  .:|||:.::|:.||..:||......|.....:||:.|.
Human   483 KKFLSTPQAGCLVDEPKQAGQYKYP--DKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLW 545

  Fly   596 CRQDGLPWTSH-------PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEK 653
            |.:.|     |       ||.|||.||.:||||.|.|    .|.|...          |...|
Human   546 CHRVG-----HRCETKFMPAAEGTVCGLSMWCRQGQC----VKFGELG----------PRPIH-- 589

  Fly   654 IIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSC 718
                                    |..|.|.:|||   |...|           ..|::...|.|
Human   590 ------------------------GQWSAWSKWSE---CSRTC-----------GGGVKFQERHC 616

  Fly   719 LNFPSR-----CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPSTL- 777
            .|...:     |.|..|.:..||...|::..:    ||..|.|.: ..|.|......|..|.|.
Human   617 NNPKPQYGGLFCPGSSRIYQLCNINPCNENSL----DFRAQQCAE-YNSKPFRGWFYQWKPYTKV 676

  Fly   778 --DASCKIFCRTRTNGTKSRRWTF--------PDGTTCKAKQHNPEDITYCISGRCERFSC---- 828
              :..||::|       |:..:.|        .|||.|..   |..|:  ||.|.||...|
Human   677 EEEDRCKLYC-------KAENFEFFFAMSGKVKDGTPCSP---NKNDV--CIDGVCELVGCDHEL 729

  Fly   829 --------------DNSTSNFFK-------------------------------MDSSFCEARSV 848
                          ||||..|:|                               :.||:...||:
Human   730 GSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSL 794

  Fly   849 R-----------------PTRDSSDQESRQQTNRQR-YAE-----------RQEGK--------- 875
            .                 |...::.:..|.....:| ||.           ..:||
Human   795 SQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYA 859

  Fly   876 -PQKNHYENEVAKRPSYG------------QGNHINAPASPYKRRNYH--------KPYPPEIPR 919
             |:..:......|||:|.            .|.:||..|...:.:|..        |..|...|:
Human   860 LPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPK 924

  Fly   920 PPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCER- 983
                       :..:.|..:.|:  ||..|.|   ||...|      |.:|.::...:.:|.::
Human   925 -----------ICNAFSCPAYWM--PGEWSTC---SKACAG------GQQSRKIQCVQKKPFQKE 967

  Fly   984 ---LQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVNGRNGH 1045
               |.:....:..|      :|:..:.|......|:. |...|...| ...::.|..|..|....
Human   968 EAVLHSLCPVSTPT------QVQACNSHACPPQWSLG-PWSQCSKTC-GRGVRKRELLCKGSAAE 1024

  Fly  1046 FPPGTRCS----PVGKRYCVYGRC 1065
            ..|.::|:    |..:..||.|||
Human  1025 TLPESQCTSLPRPELQEGCVLGRC 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	19/107 (18%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	77/214 (36%)
		Reprolysin	332..545	CDD:279729	77/215 (36%)
		TSP1	683..741	CDD:214559	15/62 (24%)
ADAMTS18	NP_955387.1	Pep_M12B_propep	86..202	CDD:279848	23/136 (17%)
		Cysteine switch. /evidence=ECO:0000250	252..259		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..291		5/32 (16%)
		ZnMc_ADAMTS_like	293..494	CDD:239801	76/213 (36%)
		Reprolysin	295..498	CDD:279729	78/215 (36%)
		TSP1	592..643	CDD:214559	16/64 (25%)
		ADAM_spacer1	749..861	CDD:283607	13/111 (12%)
		Spacer	750..876		17/125 (14%)
		TSP1	938..992	CDD:214559	13/68 (19%)
		TSP1	995..1049	CDD:214559	15/56 (27%)
		TSP1	1059..1116	CDD:214559
		TSP1	1131..1178	CDD:214559
		PLAC	1188..1218	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10482
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910