Protein Alignment stl and ADAMTS17

DIOPT Version :9

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_016877462.1
• Gene: ADAMTS17 / 170691
• HGNCID: 17109
• Length: 1189
• Species: Homo sapiens
• Alignment Length: 1187
• Identity: 272/1187 - (22%)
• Similarity: 404/1187 - (34%)
• Gaps: 372/1187 - (31%)

  Fly    60 LDKNTLVGHLREHERALIFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQR 124
            ||..|.||                :.|.:.::|...:.||::.........||        |.:|
Human    22 LDPGTAVG----------------DAAADVEVVLPWRVRPDDVHLPPLPAAPG--------PRRR 62

  Fly   125 RQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRR----TENGTQFVEHS 185
            |:.|:          ||.......||    |..|...|....|.::.:||    ...|.: ||.:
Human    63 RRPRT----------PPAAPRARPGE----RALLLHLPAFGRDLYLQLRRDLRFLSRGFE-VEEA 112

  Fly   186 PQLLKR---LERCFYRS-----PAA--ALDLC-EPGNVRGVFQQNGSDLVIHPLPARFGTGTHVL 239
            ....:|   .|.|||..     |.:  :|..| ..|.:.|:.|.....::|.||
Human   113 GAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPL----------- 166

  Fly   240 YQARVDKSGGGYS--EASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHH 302
                 :.|.|.:|  |...||..|     |...|.||        .:...||...|..:.:|...
Human   167 -----NNSQGPFSGREHLIRRKWS-----LTPSPSAE--------AQRPEQLCKVLTEKKKPTWG 213

  Fly   303 HPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMI 367
            .|.:..::||     :|.|     :..|..:||.:..|:|:..:       :.......|:|.::
Human   214 RPSRDWRERR-----NAIR-----LTSEHTVETLVVADADMVQY-------HGAEAAQRFILTVM 261

  Fly   368 NGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEK-----------L 421
            |.|..::.|.:||.:||..:.:|.:.:. .|..|......|..|.|||.||.:           .
Human   262 NMVYNMFQHQSLGIKINIQVTKLVLLRQ-RPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQ 325

  Fly   422 NPFSDADPLHYDHALVLTGLDLVTY------------------------------DKGKAN-SQV 455
            .|....||...|.|:.:|..|...:                              :..:|| ||.
Human   326 VPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVVPPAPFDVREGPGSPPWWCLGRELPEANGSQR 390

  Fly   456 V-----------GMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMH 509
            |           |:|.:.|:|::...|.:.|.......|.:|||:||||||.||....||....|
Human   391 VIPDHSISKTWEGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSH 455

  Fly   510 IMSPKLGSGK----VTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTA--GGRLPGERFNAN 568
            |||.:...|:    ::||.|||..||:||....:.||...|..:   .||.  ..:|||..::||
Human   456 IMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRS---QHTVRLPHKLPGMHYSAN 517

  Fly   569 QQCMLRFGKNFMQASTQSKME--ICRDLHCRQDGLPWTS-----HPALEGTECGPNMWCRGGTCE 626
            :||.:.||   |.|:....||  :|..|.|..:|  .||     .|.|:|||||.:.|||.|.|.
Human   518 EQCQILFG---MNATFCRNMEHLMCAGLWCLVEG--DTSCKTKLDPPLDGTECGADKWCRAGECV 577

  Fly   627 ARSSKQGSYSALKSWP-PEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPS 690
            :::            | |||:.                   .|::|           ||.|   |
Human   578 SKT------------PIPEHVD-------------------GDWSP-----------WGAW---S 597

  Fly   691 ACESGCLYGQSRRLLEGSTGLRTLNRSCLNFP-----SRCIGRDRRFVTCNTPQCHKVPVQTIND 750
            .|...|           .||.|...|.|.|.|     :.|.|.......|....|.|    .:..
Human   598 MCSRTC-----------GTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPK----GLPS 647

  Fly   751 FATQVCMQARKSDPELTGEGQQLPSTL--DASCKIFCRTRTNGTKSRRWTFP--------DGTTC 805
            |..|.|....:..|:..|   .|.:.:  |..|:::|...  |.:|     |        |||.|
Human   648 FRDQQCQAHDRLSPKKKG---LLTAVVVDDKPCELYCSPL--GKES-----PLLVADRVLDGTPC 702

  Fly   806 KAKQHNPEDITYCISGRCERFSCDNSTSNFFKMDS------------------------------ 840
                 .|.:...|:.|:|::..||....:..|.|.
Human   703 -----GPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTVKNDLC 762

  Fly   841 ---SFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPAS 902
               |.|......|...|...|:.......|.....|.||..:....:.:.:.|......|..|..
Human   763 TKVSTCVMAEAVPKCFSCYIEAAVIPAGARRIRVVEDKPAHSFLALKDSGKGSINSDWKIELPGE 827

  Fly   903 --------PYKRRNYHKPYPPEIPRPPPPASASL--------------IALDRSSSSESE----- 940
                    .|.||...:....:.|...|.....|              :.::|::.::||
Human   828 FQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQ 892

  Fly   941 -----WVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERL--QTAAEYAEQTC--- 995
                 |.     ||       |.:|.:.:..|.|...:.|     |.|:  :|.....:..|
Human   893 DSLFIWT-----HS-------GWEGCSVQCGGGERRTIVS-----CTRIVNKTTTLVNDSDCPQA 940

  Fly   996 ARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKYR-----YYLVNGRNGH------FPPG 1049
            :|...:||..:.|..| |..:..|...|...|:..| ::|     |.|.||.  |      :.||
Human   941 SRPEPQVRRCNLHPCQ-SRWVAGPWSPCSATCEKGF-QHREVTCVYQLQNGT--HVATRPLYCPG 1001

  Fly  1050 TRCSPVGKRYCVYGRCL 1066
            .|  |...:.|....||
Human  1002 PR--PAAVQSCEGQDCL 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	23/98 (23%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	70/268 (26%)
		Reprolysin	332..545	CDD:279729	71/269 (26%)
		TSP1	683..741	CDD:214559	16/62 (26%)
ADAMTS17	XP_016877462.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810