Protein Alignment stl and ADAMTS16

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_047272830.1
• Gene: ADAMTS16 / 170690
• HGNCID: 17108
• Length: 1258
• Species: Homo sapiens
• Alignment Length: 1172
• Identity: 286/1172 - (24%)
• Similarity: 421/1172 - (35%)
• Gaps: 358/1172 - (30%)

  Fly    19 LTTLWLLIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALIFGSRS- 82
            |..||:|:...:..:...:..|                                 .|...||.|
Human    11 LAALWMLLAQVAEQAPACAMGP---------------------------------AAAAPGSPSV 42

  Fly    83 -----PEEAP------EFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQRRQRRSLPSEDGN 136
                 |.|.|      |:.||        ....::.|   |:...|....||||:|
Human    43 PRPPPPAERPGWMEKGEYDLV--------SAYEVDHR---GDYVSHEIMHHQRRRR--------- 87

  Fly   137 GPLPPEEEE----QEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFY 197
             .:|..|.|    :..|...:..:.|:.|..|:...||.....:.||:    |.|.|...:.|||
Human    88 -AVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTK----SVQTLPPEDFCFY 147

  Fly   198 -------RSPAAALDLCEPGNVRGVFQQNGSDLVIHPLP----------ARFGTGTHVLYQARVD 245
                   |:.:.||..|:  .:.|:.:...:|..:.|||          |:..:.:||||:...:
Human   148 QGSLRSHRNSSVALSTCQ--GLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTE 210

  Fly   246 KSGGGYSE--ASSRR---TASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPH 305
            ....|.||  .:||.   ...||.|                         |.|||....:
Human   211 PHAPGASEVLVTSRTWELAHQPLHS-------------------------SDLRLGLPQK----- 245

  Fly   306 QHHQQRRRRYIGDAPRSRWSDIP-------------------EELFIETAIFVDSDLYAHMQKNF 351
            ||...||::|:...|:.....:|                   |||.:||.:.||..:   ||.:.
Human   246 QHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKM---MQNHG 307

  Fly   352 PTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCK 416
            ..|    :.:::|.::|.|..|:...|:|..||..:..|.:.:. :.||||.|...::.|:|||:
Human   308 HEN----ITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLED-EQPGLVISHHADHTLSSFCQ 367

  Fly   417 WQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFES 481
            ||..|   ...|...:|||::|||||:.::.....::  :|.|.:.|||:...||||||......
Human   368 WQSGL---MGKDGTRHDHAILLTGLDICSWKNEPCDT--LGFAPISGMCSKYRSCTINEDTGLGL 427

  Fly   482 VFVVAHEIGHNLGMRHDAKEISCDPTM-HIMSPKLG--SGKVTWSKCSRTYLEDFLMDPQAECLF 543
            .|.:|||.|||.||.||.:...|..:. :||||.|.  :|..:||.|||.||..||...||.||.
Human   428 AFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLA 492

  Fly   544 DRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPWTSH-- 606
            |:......:.:..  :||||.::||.||..:||:.........|.:||:.|.|.:.|....:.
Human   493 DQPKPVKEYKYPE--KLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFM 555

  Fly   607 PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNP 671
            ||.|||.||.:||||||.| .:...:|             |:.||
Human   556 PAAEGTICGHDMWCRGGQC-VKYGDEG-------------PKPTH-------------------- 586

  Fly   672 MDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN-FPSR----CIGRDRR 731
                     .:|.:||..|.|...|..|.|.|           :|.|.| .||.    |.|..|.
Human   587 ---------GHWSDWSSWSPCSRTCGGGVSHR-----------SRLCTNPKPSHGGKFCEGSTRT 631

  Fly   732 FVTCNTPQCHKVPVQTINDFATQVCMQAR---------KSDPELTGEGQQLPSTLDASCKIFCRT 787
            ...||:.:|.:..|    ||....|.:..         |..|....|.|.|       ||::|..
Human   632 LKLCNSQKCPRDSV----DFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDL-------CKLYCIA 685

  Fly   788 R--------TNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCDN-------------- 830
            .        :|..|       |||.|.....|     .||.|.|||..|||
Human   686 EGFDFFFSLSNKVK-------DGTPCSEDSRN-----VCIDGICERVGCDNVLGSDAVEDVCGVC 738

  Fly   831 ------------------STSNFFKMDSSFCEARSVR--PTRDSSDQESRQQTNRQRYAERQ--- 872
                              .|:.::.|.:....|||:|  ....|:...|.:...|:.|....
Human   739 NGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTV 803

  Fly   873 -------------EGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPR----P 920
                         :.:...|..||.:|..|:    |........::.||....:...:||    .
Human   804 DWPGRYKFSGTTFDYRRSYNEPENLIATGPT----NETLIVELLFQGRNPGVAWEYSMPRLGTEK 864

  Fly   921 PPPASASLI-ALDRSSSSES----EWVAHPGCH---------SNCMTDSKGVQGVTSRLTGVESI 971
            .|||..|.. |:.||..|.|    :.....||:         |.|...::.|.|
Human   865 QPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTG----------- 918

  Fly   972 QLCSYRIQPCERLQTAAEYA--EQTC-----ARYRQKVRGLSGHGAQISASI-DEPDRSCRVGCQ 1028
             |...::..|....:...::  .:||     :|..|..|.:......:.||: .:|..|.|..|.
Human   919 -LVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACN 982

  Fly  1029 DE 1030
            .:
Human   983 SQ 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	79/214 (37%)
		ADAMTS_CR_2	561..625	CDD:465496	28/65 (43%)
		TSP1	683..741	CDD:214559	19/62 (31%)
ADAMTS16	XP_047272830.1	Pep_M12B_propep	78..205	CDD:460254	34/142 (24%)
		ZnMc_ADAMTS_like	290..491	CDD:239801	78/213 (37%)
		ADAMTS_CR_2	508..575	CDD:465496	29/67 (43%)
		TSP1	589..641	CDD:214559	19/62 (31%)
		ADAMTS_CR_3	645..745	CDD:437068	28/122 (23%)
		ADAMTS_spacer1	747..858	CDD:461796	18/114 (16%)
		TSP1_ADAMTS	931..986	CDD:465950	11/54 (20%)
		TSP1_ADAMTS	1031..1081	CDD:465950
		TSP1_ADAMTS	1089..1148	CDD:465950
		TSP1_ADAMTS	1164..1214	CDD:465950
		PLAC	1224..1254	CDD:462560