DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment stl and ADAMTS5

DIOPT Version :9

Sequence 1:NP_001097423.1 Gene:stl / 37619 FlyBaseID:FBgn0086408 Length:1136 Species:Drosophila melanogaster
Sequence 2:NP_008969.2 Gene:ADAMTS5 / 11096 HGNCID:221 Length:930 Species:Homo sapiens


Alignment Length:1073 Identity:248/1073 - (23%)
Similarity:379/1073 - (35%) Gaps:278/1073 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 AQQRPEEQQRLEERKRPGEAEQH----GGNPH---QRRQRRSLPSE-----DGNGPLPPEEEEQE 147
            |.|.|......:.|:|.||..|.    .|:||   |||:.:.|...     .|.|         :
Human    31 AGQPPTAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGG---------K 86

  Fly   148 AGEDVEA-----RLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYR-----SP-- 200
            .|..|.|     .|.|::...:....|:   ....||.    :|  .:....||||     ||  
Human    87 VGYLVYAGGRRFLLDLERDGSVGIAGFV---PAGGGTS----AP--WRHRSHCFYRGTVDGSPRS 142

  Fly   201 AAALDLCEPGNVRGVFQQNGSDLVIHPL---------PAR-FGTGTHVLYQARV----DKSGGGY 251
            .|..|||  |.:.|.|....:...:.||         ..| :|.|:     ||:    .:.|..:
Human   143 LAVFDLC--GGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGS-----ARILHVYTREGFSF 200

  Fly   252 SEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQL--QSPLRLRFQPRHHHPHQHHQQRRRR 314
            .....|.:.....|..:....|...:.|..|....|||  ||.|    .|......|...:||||
Human   201 EALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSAL----SPAGGSGPQTWWRRRRR 261

  Fly   315 YIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTL 379
            .|..|.:           :|..:..|    |.|.:.:....:    .:||.:.:....||.|.::
Human   262 SISRARQ-----------VELLLVAD----ASMARLYGRGLQ----HYLLTLASIANRLYSHASI 307

  Fly   380 GRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLV 444
            ...|...:.::.:....| ..|..|::....|.:|||||.:.|...|....|||.|::.|..||.
Human   308 ENHIRLAVVKVVVLGDKD-KSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLC 371

  Fly   445 TYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTM- 508
                |..:...:|||.|..:|:...||.:.|.....:.|.|||||||.||:.||..:. |:.|. 
Human   372 ----GHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKF-CEETFG 431

  Fly   509 -----HIMSPKLGS--GKVTWSKCSRTYLEDFLMDPQAECLFD--RDSFAGPWDHTAGGRLPGER 564
                 .:||..|.|  ....||||:...:.:||.|....||.|  |....||.:      |||:.
Human   432 STEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEE------LPGQT 490

  Fly   565 FNANQQCMLRFGKNFMQASTQSKMEICRDLHC---RQDGLPWTSH--PALEGTECGPNMWCRGGT 624
            ::|.|||.|.||..:   |....|::|..|.|   ||..:...:.  ||:|||.||....|..|.
Human   491 YDATQQCNLTFGPEY---SVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGK 552

  Fly   625 CEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEP 689
            |..::.|: .||.                                        .|..|||.|...
Human   553 CVDKTKKK-YYST----------------------------------------SSHGNWGSWGSW 576

  Fly   690 SACESGCLYG-----------QSRRLLEGSTGLRTLNRSCLNFPSRCIGRDRRFVTCNTPQCHKV 743
            ..|...|..|           ..|......||.|.:.|||...|....|:..|...|.....::.
Human   577 GQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQS 641

  Fly   744 PVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNG---TKSRRWTFPDGTTC 805
            ..:.:..|...|        |:..|   .||:.:   ||:.||.:..|   ..|.:.|  |||.|
Human   642 DAKGVKTFVEWV--------PKYAG---VLPADV---CKLTCRAKGTGYYVVFSPKVT--DGTEC 690

  Fly   806 KAKQHNPEDITYCISGRCERFSCDNSTSNFFKMDS-SFCEARSVRPTR--DSSDQESRQQTNRQR 867
            :...:     :.|:.|:|.|..||....:..:.|. ..|...:...|:  .:.:::|:..|:..|
Human   691 RLYSN-----SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVR 750

  Fly   868 YAE-------RQEGKPQKNHYENEVAKRPSYGQ----GNHINAPASPYKRRNYHKPYPPEIPRPP 921
            ..|       ||.....:..:...:|.:...|:    |.::.:                      
Human   751 IPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMIS---------------------- 793

  Fly   922 PPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQT 986
              .|.::|.::.:..:.|.|     .|.:......|.......|.    :|:.:  ..|.:.|. 
Human   794 --TSETIIDINGTVMNYSGW-----SHRDDFLHGMGYSATKEILI----VQILA--TDPTKPLD- 844

  Fly   987 AAEYAEQTCARYRQKVRGLSGHGA-QISASIDEP----------DRSCRVG-------CQDEFIK 1033
             ..|:.....:...||..::.||: ::.:...:|          .|:|..|       |||...|
Human   845 -VRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRK 908

  Fly  1034 YRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCL 1066
                |..|          | |:.:|...:.:||
Human   909 ----LAKG----------C-PLSQRPSAFKQCL 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stlNP_001097423.1 Pep_M12B_propep <155..239 CDD:279848 24/100 (24%)
ZnMc_ADAMTS_like 331..543 CDD:239801 63/219 (29%)
Reprolysin 332..545 CDD:279729 65/222 (29%)
TSP1 683..741 CDD:214559 17/68 (25%)
ADAMTS5NP_008969.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..69 13/37 (35%)
Pep_M12B_propep 67..168 CDD:307618 27/120 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..231 4/24 (17%)
Cysteine switch. /evidence=ECO:0000250 207..214 0/6 (0%)
ZnMc_ADAMTS_like 269..473 CDD:239801 63/217 (29%)
TSP1 570..622 CDD:214559 14/51 (27%)
Spacer 732..874 25/178 (14%)
ADAM_spacer1 732..852 CDD:310520 21/156 (13%)
TSP1 879..930 CDD:214559 14/63 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6268
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.760

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